A5031025675- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
- Neurological diseases and metabolism
- S100 Proteins and Annexins
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Bioinformatics and Genomic Networks
- Amyotrophic Lateral Sclerosis Research
- Stress Responses and Cortisol
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Heat shock proteins research
- Health, Environment, Cognitive Aging
- Retinal Imaging and Analysis
- Gene expression and cancer classification
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Genital Health and Disease
- Vanadium and Halogenation Chemistry
- Medication Adherence and Compliance
- Nuclear Receptors and Signaling
Duke Medical Center
2007-2024
Duke University Hospital
2005-2023
Duke University
2005-2022
Thomas Jefferson University
2019
Rowan University
2019
Neurology, Inc
2007
VA Palo Alto Health Care System
2005
University of Mississippi Medical Center
2005
Jackson Memorial Hospital
2005
Medical University of South Carolina
2005
<h3>Importance</h3> Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations African ancestry compared European or Asian ancestry. Despite this, individuals remain understudied genomic research for blinding disorders. <h3>Objectives</h3> To perform genome-wide association study (GWAS) evaluate potential mechanisms pathogenesis loci associated primary glaucoma. <h3>Design, Settings, Participants</h3> A 2-stage GWAS discovery data...
The frontotemporal dementias (FTDs) are a heterogeneous group of neurodegenerative disorders that characterized clinically by dementia, personality changes, language impairment, and occasionally extrapyramidal movement disorders. Historically, the diagnosis classification FTDs has been fraught with difficulties, especially regard to establishing consensus on neuropathologic diagnosis. Recently, an international scientists participated in conference develop such criteria. They recommended...
Abstract Objective: It is currently unknown whether cerebrospinal fluid (CSF) neurosteroid levels are related to brain in humans. CSF and dehydroepiandrosterone (DHEA) elevated patients with Alzheimer’s disease (AD), but it unclear DHEA correlated within the same subject cohort. We therefore determined pregnenolone AD (n = 25) cognitively intact control subjects 16) both temporal cortex. Design: were by gas chromatography/mass spectrometry preceded HPLC. Frozen cortex specimens provided...
Our hypothesis is that changes in gene and protein expression are crucial to the development of late-onset Alzheimer’s disease. Previously we examined how DNA alleles control downstream RNA transcripts those relationships changed We have now proteins incorporated into networks two separate series evaluated our outputs different cell lines. pipeline included following steps: (i) predicting quantitative trait loci; (ii) determining differential expression; (iii) analysing transcript...
The Bryan Alzheimer Disease Research Center obtains postmortem human brain tissue from patients with disease (AD) and cognitively normal control subjects for molecular genetic research programs. A growing body of suggests that variations in gene transcript levels may contribute to the onset progression disease. Identifying how regulation expression affect AD requires use high-quality mRNA banked brains. present study was conducted establish quality suitability available future studies. We...
The molecular genetic basis that leads to Lewy Body (LB) pathology in 15–20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA) and Leucine-rich repeat kinase2 (LRRK2) have been implicated the pathogenesis Parkinson's (PD), prototype LB spectrum disorders. We tested association SNCA variants with AD. then stratified analyses by LRRK2 genotype. also investigated expression regulation relation pathology. evaluated differences SNCA-mRNA LRRK2-mRNA levels as a...
Abstract Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 and TSC2 genes autosomal dominantly inherited. These cause hyperactivation of mammalian Target Rapamycin (mTOR) pathway, leading to development nonmalignant masses involving various organ systems. Patients with TSC also experience neuropsychiatric symptoms collectively termed Sclerosis Complex Associated Neuropsychiatric Disorder (TAND). Due research advancements TSC, patients now live...
We analyzed smooth muscle actin (SMA) immunoreactivity in brain blood vessels of 10 ApoE 4,4 Alzheimer disease (AD) patients and 3,3 AD matched for age, sex, duration dementia. also examined cognitively neuropathologically normal controls age sex. Vascular SMA the arachnoid, grey matter, white matter was quantified by image analysis. There less all when compared to (p < 0.001). In addition, arachnoidal had than 0.05). is decreased vascular density with matched, controls. The severity loss...
Autopsy information on cardiovascular damage was investigated for pathologically confirmed Alzheimer disease (AD) patients (n=84) and non-AD control (n=60). The 51 relevant items were entered into a grade-of-membership model to describe vascular in AD. Five latent groups identified "I: early-onset AD," "II: controls, cancer," "III: extensive atherosclerosis," "IV: late-onset AD, male," "V: female." Expectedly, Groups IV V had elevated APOE epsilon 4 frequency. Unexpectedly, there limited...
Abstract Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular organelles, other debris. The structure, morphology, suspected functions of CA in the brain imply disease relevance. Despite this, link between age-related neurodegenerative diseases, particularly Alzheimer’s (AD), remains poorly defined. We performed a neuropathological analysis...
Tau aggregates are present in multiple neurodegenerative diseases known as "tauopathies," including Alzheimer's disease (AD), Pick's (PiD), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Such misfolded tau therefore potential sources for tauopathy biomarker discovery. Using the antibody screening approach targeting high-molecular-weight aggregates, we tested several antibodies a comprehensive set of site-specific phospho-tau (p-tau) phosphorylation sites showing...