A5078227829- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Acute Lymphoblastic Leukemia research
- Retinal Diseases and Treatments
- Environmental Toxicology and Ecotoxicology
- Paraoxonase enzyme and polymorphisms
- Insect and Pesticide Research
- Pesticide and Herbicide Environmental Studies
- Cancer-related Molecular Pathways
- Biochemical and Molecular Research
- Genetically Modified Organisms Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Effects of Radiation Exposure
- Aquaculture disease management and microbiota
- Bat Biology and Ecology Studies
- Radioactive contamination and transfer
- Marine animal studies overview
- Ophthalmology and Eye Disorders
- Wastewater Treatment and Reuse
- Effects and risks of endocrine disrupting chemicals
- Retinopathy of Prematurity Studies
- Animal Genetics and Reproduction
- Essential Oils and Antimicrobial Activity
Universidade Federal de Goiás
2018-2023
Universidade Estadual de Campinas (UNICAMP)
2011-2019
Pontifícia Universidade Católica de Goiás
2013
Hospital de Clínicas da Unicamp
2012
<h3>Importance</h3> Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations African ancestry compared European or Asian ancestry. Despite this, individuals remain understudied genomic research for blinding disorders. <h3>Objectives</h3> To perform genome-wide association study (GWAS) evaluate potential mechanisms pathogenesis loci associated primary glaucoma. <h3>Design, Settings, Participants</h3> A 2-stage GWAS discovery data...
Like other phthalates, diethyl phthalate (DEP) is considered as a contaminant of emerging concern (CEC) due to its ease in migrating from package water and food, hence contaminate consumers, being metabolized excreted the urine. Its presence has negative impact on aquatic ecosystems, especially with respect disruption endocrine system reproductive disorders humans. It mainly enters bodies via sewage effluents effluent treatment plants, incomplete or inefficient removal. The objective this...
Large-scale genome-wide association studies have identified several susceptibility variants associated with the risk of primary open-angle glaucoma (POAG), among which rs4236601 (CAV1/CAV2) at chromosome 7q31 and rs2157719 9p21 (CDKN2B-AS1). The purpose this study was to investigate whether these contribute incidence POAG in a sample Brazilian Southeastern population determine best-fitted genetic model for single nucleotide polymorphisms (SNPs). A case-control 557 individuals, 310 POAG, 247...
PP2A is the main serine/threonine-specific phosphatase in animal cells. The active has been described as a holoenzyme consisting of catalytic, scaffolding, and variable regulatory subunit, all encoded by multiple genes, allowing for assembly more than 70 different holoenzymes. catalytic subunit can also interact with α4, TIPRL (TIP41, TOR signaling pathway regulator-like), methyl-transferase LCMT-1, methyl-esterase PME-1. Here, we report that gene encoding PP2Acα generate two mRNA types,...
A serious radiological accident occurred in 1987 Goiânia, Brazil, which lead to extensive human and environmental contamination as a result of ionising radiation (IR) from caesium-137. Among the exposed were those direct contact with caesium-137, their relatives, neighbours, liquidators health personnel involved handling radioactive material clean-up sites. The group consisted 10 two-generation families, totalling 34 people. For each family, at least one progenitors was directly very low...
Brazil is one of the largest pesticide consumers in world, mainly due to its intense agricultural activity. The State Goias, situated Central Brazil, a region recognized as an essential producer soy, corn, beans, sorghum, sugar cane, and cotton. In this study, we evaluated 602 unrelated individuals, distributed central southern regions presenting combined frequencies (haplotypes) GSTT1 GSTM1 genes. all municipalities, frequency null genotype was 38.2% 50.3%. Goiania, capital presented...
Healthy radio-exposed individuals who received low levels of Cesium-137 radiation during the accident that occurred in Goiânia 1987, their families and controls were tested for detection t(14;18)-rearranged B cells peripheral blood by using a highly sensitive, real-time quantitative PCR method.The chromosomal translocation t(14;18)(q32;q21) is characteristic follicular lymphoma frequent abnormality observed other types non-Hodgkin's ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research...
PP2A is the main serine/threonine‐specific phosphatase in animal cells. The active has been described as a holoenzyme consisting of catalytic, scaffolding, and variable regulatory subunit, allowing for assembly more than 70 different holoenzymes. catalytic subunit can also interact with α4, TIPRL, methyl‐transferase LCMT‐1, methyl‐esterase PME‐1. Here, we report that gene encoding PP2Acα generate two mRNA types, standard shorter isoform, lacking exon 5, which termed PP2Acα2. Higher levels...
Abstract In Brazil, high levels of agricultural activity are reflected in the consumption enormous amounts pesticide. The production grain Brazil has been estimated to reach 289.8 million tons 2022 harvest, an increase 14.7% comparison with 2021, even greater being predicted for Goiás, one country’s principal producing states. These advances likely associated a progressive occupational exposure rural workers pesticides. PON1 gene activates enzymes involved phase I liver detoxification. rs662...