A5102835922- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Mosquito-borne diseases and control
- Insect Pest Control Strategies
- Sepsis Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Dermatoglyphics and Human Traits
- Insect and Pesticide Research
- Ocular Surface and Contact Lens
- Asthma and respiratory diseases
- Retinopathy of Prematurity Studies
- NF-κB Signaling Pathways
- Ophthalmology and Visual Impairment Studies
- Mechanical Circulatory Support Devices
- Phosphodiesterase function and regulation
- Corneal Surgery and Treatments
- Respiratory and Cough-Related Research
Universidade Estadual de Campinas (UNICAMP)
2010-2019
Hospital de Clínicas da Unicamp
2014
Universidade Federal do Rio de Janeiro
2001-2010
Universidade de Ribeirão Preto
2008
Hospital Federal dos Servidores do Estado
2008
The aim of this study is to test the hypothesis that recruitment maneuvers (RMs) might act differently in models pulmonary (p) and extrapulmonary (exp) acute lung injury (ALI) with similar transpulmonary pressure changes.Prospective, randomized, controlled experimental study.University research laboratory.Wistar rats were randomly divided into four groups. In control groups, sterile saline solution was intratracheally (0.1 mL, Cp) or intraperitoneally (1 Cexp) injected, whereas ALI animals...
<h3>Importance</h3> Primary open-angle glaucoma presents with increased prevalence and a higher degree of clinical severity in populations African ancestry compared European or Asian ancestry. Despite this, individuals remain understudied genomic research for blinding disorders. <h3>Objectives</h3> To perform genome-wide association study (GWAS) evaluate potential mechanisms pathogenesis loci associated primary glaucoma. <h3>Design, Settings, Participants</h3> A 2-stage GWAS discovery data...
Abstract Here we investigated H 2 O production and detoxification in the hematophagous hemiptera, Rhodnius prolixus . Superoxide dismutase (SOD) catalyzes dismutation of superoxide radical (O – ). This reaction produces hydrogen peroxide, which is scavenged by antioxidant enzymes such as catalase (CAT). SOD CAT activities were found all tissues studied, being highest midgut. was dose‐dependently inhibited vivo injections 3‐amino‐1,2,4‐triazole (AT). Insects treated with AT showed a twofold...
We tested the hypothesis that at early phase of acute lung injury (ALI) degree endothelium may predict parenchyma remodelling. For this purpose, two models extrapulmonary ALI induced by Escherichia coli lipopolysaccharide (ALI-LPS) or cecal ligation and puncture (ALI-CLP) were developed in mice. At day 1, these had similar degrees mechanical compromise, epithelial damage, intraperitoneal inflammation, but endothelial lesion was greater ALI-CLP. A time course analysis revealed, 7: ALI-CLP...
The aim of this study was to investigate the association five polymorphisms in IL1A and IL1B genes Brazilian patients with primary open angle glaucoma (POAG). A case–control study, including 214 unrelated POAG 187 healthy individuals, conducted evaluate frequency genes. Ophthalmic evaluation performed genomic DNA obtained from all participants. Five single nucleotide (SNPs): (–889C/T: rs1800587:C > T, +4845G/T:rs17561G>T) (–31C/T:rs1143627:T C, –511C/T:rs16944C>T...
The aim of the present study was to compare efficacy a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that dexamethasone in murine model chronic asthma. Lung mechanics (airway resistance, viscoelastic pressure, static elastance), histology, airway lung parenchyma remodeling (quantitative analysis collagen elastic fiber) were analyzed. Thirty-three BALB/c mice randomly assigned four groups. In asthma group (N = 9), immunized 10 µg ovalbumin (OVA, ip) on 7 alternate days, after...
Relato dos resultados do estudo de uma família com distrofia corneana endotelial associada a disgenesia segmento anterior, anomalia Axenfeld-Rieger. Paciente 56 anos, feminina, queixava-se visão borrada. O exame na lâmpada fenda evidenciou embriotoxo posterior bilateral e guttata no centro da córnea, edema estromal dobras membrana Descemet, caracterizando endothelial Fuchs. A filha 27 anos estava assintomática. biomicroscopia revelou nasal temporal central. [...]