A5101754478- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Bone health and osteoporosis research
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Ion channel regulation and function
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Diabetes Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Traditional Chinese Medicine Analysis
- Heart Failure Treatment and Management
- Plant and fungal interactions
- Diagnosis and Treatment of Venous Diseases
- Bipolar Disorder and Treatment
- Turfgrass Adaptation and Management
- Enhanced Recovery After Surgery
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Connective Tissue Growth Factor Research
- Hypothalamic control of reproductive hormones
Gansu Provincial Hospital
2016-2025
University of Electronic Science and Technology of China
2025
Lanzhou University
2019-2025
Inner Mongolia University of Science and Technology
2023
Baotou Medical College
2023
Second Affiliated Hospital of Fujian Medical University
2019
Fujian Medical University
2019
National Clinical Research Center for Digestive Diseases
2019
Huazhong University of Science and Technology
2015
Hubei University of Chinese Medicine
2013
Elevated thyroid-stimulating hormone (TSH) and hypercholesterolemia commonly coexist, as typically seen in hypothyroidism, but there is no known mechanism directly linking the two. Here, we demonstrated that liver cells, TSH promoted expression of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR), a rate-limiting enzyme cholesterol synthesis, by acting on receptor hepatocyte membranes stimulating cyclic adenosine monophosphate / protein kinase monophosphate–responsive element binding...
The function of thyrotropin (TSH) in the thyroid gland is mediated by receptor (TSHR). In addition to thyroid, TSHR expression has been described some non-thyroidal tissues, although it uncertain whether present hepatocytes. One study reported hepatic mRNA, but this was considered be because illegitimate transcription, and there not a investigating its protein Here, we examined human rat liver as well normal hepatocyte cell line L-02. Our results demonstrated that mRNA could detected had...
Recent studies have reported that subclinical hypothyroidism (SCH) is associated with atherosclerosis (AS). Thyroid hormone maintained at normal levels in patients SCH, whereas TSH increased. However, the pathogenesis of AS association SCH only partially understood. In addition, endothelial dysfunction plays an important role development AS. The purpose present research was to study direct effect on human umbilical vein cells (HUVECs). expression some genes after treatment evaluated by...
Background Osteoporosis is one of the most common systemic metabolic bone diseases, especially in postmenopausal women. Circular RNA (circRNA) has been implicated various human diseases. However, potential role circRNAs osteoporosis (PMOP) remains largely unknown. The study aims to identify biomarkers and further understand mechanism PMOP by constructing a circRNA-associated ceRNA network. Methods PMOP-related datasets GSE161361, GSE64433, GSE56116 were downloaded from Gene Expression...
Objective Subclinical hypothyroidism (SCH) and its associations with atherosclerosis (AS) cardiovascular disease remain controversial. The purpose of our study was to observe changes in endothelial functioning hemodynamics rats SCH determine whether L-thyroxine (L-T4) administration affects these changes. Methods In total, sixty male Wistar were randomly divided into the following three groups 20 each: control euthyroid rats, that had been treated thyroxine (SCH+T4). induced by 10...
// Jiajia Dong 1 , Cuixia Gao 2 Jing Liu Yunshan Cao 3 and Limin Tian Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, Gansu, China Ultrasonic Diagnosis, Cardiology, Correspondence to: Tian, email: Keywords : TSH, SERCA2a, cardiomyocyte, PLN, PKA, Pathology Section Received November 10, 2015 Accepted April 16, 2016 Published May Abstract Elevated thyroid-stimulating hormone (TSH) levels often accompany impaired LV diastolic function subtle systolic dysfunction in subclinical...
Abstract Obstructive sleep apnea syndrome (OSAS) can lead to alterations in right ventricular (RV) performance and pulmonary vascular haemodynamics. Additionally, altitude-related hypoxia is associated with vasoconstriction, the effect of high-altitude on circulation OSAS patients be further altered. We sought assess RV morphology function living at high altitude by way 2-dimensional speckle tracking echocardiography (2D-STE), real-time 3- dimensional (RT-3DE) cardiac biomarkers. also...
Abstract The effect of leucine on glucose‐stimulated insulin secretion (GSIS) in pancreatic β‐cells is quite controversial, and mechanism involved the has not been elucidated yet. Consequently, we aimed to investigate GSIS its focusing contribution AMP‐activated protein kinase (AMPK) pancreatic/duodenal homeobox‐1 (PDX‐1). Rat insulinoma (INS‐1, RIN m5F, DN‐PDX‐1#28 PDX‐1#6) were cultured with or without leucine, AICAR (AMPK agonist) compound C antagonist) for 48 hrs. In contrast control,...