A5082797450- Metallurgical Processes and Thermodynamics
- Multiple Myeloma Research and Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ubiquitin and proteasome pathways
- Fluid Dynamics and Mixing
- Iron and Steelmaking Processes
- Protein Degradation and Inhibitors
- Gut microbiota and health
- Combustion and flame dynamics
- Solidification and crystal growth phenomena
- Histone Deacetylase Inhibitors Research
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Heat Transfer Mechanisms
- Ferroptosis and cancer prognosis
- Nanofluid Flow and Heat Transfer
- Material Dynamics and Properties
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Photorefractive and Nonlinear Optics
- Minerals Flotation and Separation Techniques
- Particle Dynamics in Fluid Flows
- Peptidase Inhibition and Analysis
Wuhan University of Technology
2025
Smart Material (Germany)
2025
State Key Laboratory of Advanced Technology For Materials Synthesis and Processing
2025
University of South China
2021-2024
Central South University
2018-2023
Ministry of Education of the People's Republic of China
2022-2023
Xiangya Hospital Central South University
2018-2022
National Health and Family Planning Commission
2018-2022
University of Iowa
2013-2021
Ministry of Health
2020
Aerobic glycolysis, a hallmark of cancer, is characterized by increased metabolism glucose and production lactate in normaxia. Recently, pyruvate kinase M2 (PKM2) has been identified as key player for regulating aerobic glycolysis promoting tumor cell proliferation survival. Tandem affinity purification followed up mass spectrometry (TAP-MS) co-immunoprecipitation (Co-IP) were used to study the interaction between NIMA (never mitosis gene A)-related 2 (NEK2) heterogeneous nuclear...
Abstract Background Gut microbiome alterations are closely related to human health and linked a variety of diseases. Although great efforts have been made understand the risk factors for multiple myeloma (MM), little is known about role gut its metabolic functions in development MM. Results Here, cohort newly diagnosed patients with MM healthy controls (HCs), significant differences metagenomic composition were discovered, first time, higher bacterial diversity Specifically,...
Abstract Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA of exporter ferroportin (FPN1) significantly downregulated myeloma cells correlates negatively clinic outcome. Restoring FPN1 reduces intracellular liable pool, inhibits STAT3-MCL-1 signaling, suppresses growth. Furthermore, also at the initial stages osteoclast...
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high confers inferior survival myeloma (MM); thus, a better understanding of the mechanisms by which induces MM required. In this study, we discovered enhances cell autophagy, and combination autophagy inhibitor chloroquine (CQ) chemotherapeutic bortezomib (BTZ) significantly prevents NEK2-induced cells. Interestingly, was found to bind stabilize Beclin-1 protein but did not affect its mRNA...
Abstract Metabolites in the tumor microenvironment are a critical factor for progression. However, lack of knowledge about metabolic profile bone marrow (BM) multiple myeloma (MM) limits our understanding MM Here, we show that glycine concentration BM is elevated due to collagen degradation mediated by cell-secreted matrix metallopeptidase 13 (MMP13), while level linked cells utilize channel protein solute carrier family 6 member 9 (SLC6A9) absorb extrinsic subsequently involved synthesis...
Summary The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown that bortezomib (BTZ) resistance associated with an increase the SSP myeloma (MM) cells; however, underlying mechanisms of SSP‐induced BTZ remain unclear. In this study, we found phosphoglycerate dehydrogenase (PHGDH), first rate‐limiting enzyme SSP, was significantly elevated CD138 + cells derived from patients relapsed MM. Moreover, high PHGDH conferred inferior survival We also...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show thrombocytopenia linked to poor prognosis In addition, identify serine, which released from MM cells into the bone marrow microenvironment, as key metabolic factor that suppresses megakaryopoiesis thrombopoiesis. The impact excessive serine on mainly mediated through suppression megakaryocyte (MK)...
// Ye Yang 1, * , Wen Zhou Jiliang Xia 1 Zhimin Gu Erik Wendlandt Xin Zhan 2 Siegfried Janz 3 Guido Tricot Fenghuang Department of Internal Medicine, University Iowa Carver College City, United States Vanderbilt University, Nashville, Tennessee, Pathology, Co-first authors Correspondence to: Zhan, email: fenghuang-zhan@uiowa.edu Keywords: Plasma cell myeloma, aldehyde dehydrogenase, NIMA-related kinase, tumor-initiating Received: July 05, 2014 Accepted: August...
High-dose chemotherapies to treat multiple myeloma (MM) can be life-threatening due toxicities normal cells and there is a need target only tumor and/or lower standard drug dosage without losing efficacy. We show that pharmacologically-dosed ascorbic acid (PAA), in the presence of iron, leads formation highly reactive oxygen species (ROS) resulting cell death. PAA selectively kills CD138+ MM derived from smoldering (SMM) but not monoclonal gammopathy undetermined significance (MGUS)...
Abstract Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, distant is major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression associated with a poor prognosis patients NPC inhibits chemotherapy‐induced senescence in cells. In this study, we found COX‐2 was upregulated cancer‐associated fibroblasts (CAFs) derived from by RNA‐Seq. Furthermore, elevated CAF detected survival using...
Abstract It has been previously shown that (never in mitosis gene A)‐related kinase 2 ( NEK2 ) is upregulated multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood. In study, it found amplification of hypermethylation distal CpG islands its promoter correlate strongly with increased expression. Patients have a poor rate survival often exhibit TP53 deletion, which an independent prognostic factor MM. This...
Abstract 1,4‐di(4′‐ N , ‐diphenylaminostyryl)benzene (DPA‐DSB) is a well known compound with large two‐photon absorption (TPA) section and strong fluorescence in solution. However, the ease which it crystallizes results formation of discontinuous crystalline phases during vacuum deposition processes, thereby greatly limiting its applicability solid‐state devices. A cruciform dimer DPA‐DSB, 2,5,2′,5′‐tetra(4′‐ ‐diphenylaminostyryl)biphenyl (DPA‐TSB) reported, wherein two DPA‐DSB molecules are...
Abstract Background Treatment failures in cancers, including multiple myeloma (MM), are most likely due to the persistence of a minor population tumor-initiating cells (TICs), which noncycling or slowly cycling and very drug resistant. Methods Gene expression profiling real-time quantitative reverse transcription polymerase chain reaction were employed define genes differentially expressed between side-population cells, contain TICs, main MM derived from 11 patient samples. Self-renewal...
Multiple myeloma (MM), a terminally differentiated B cell malignancy, remains difficult to cure. Understanding the molecular mechanisms underlying progression of MM may identify therapeutic targets and lead fundamental shift in treatment disease. Deubiquitination, like ubiquitination, is highly regulated process, implicated almost every cellular process. deubiquitinating enzymes (DUBs) have been identified, but their regulation poorly defined. Here, we determined that TRIP13 increases...
Indigo is one of the most well‐known natural dyes and has attracted significant research interest due to its low cost exceptional stability. Notably, bay‐annulated indigo (BAI) been reported as an effective electron acceptor widely used in various applications. Herein, we successfully synthesize a methylthio‐substituted BAI derivative, compound 1 investigate impact methylthio substitution on optoelectronic properties. UV‐vis absorption fluorescence spectra reveal that displays red shift...
Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but the molecular mechanism of its pathogenesis poorly understood. Our previous work demonstrated that NEK2 overexpressed multiple cancers. However, how involves NPC development remains to be elucidated. In this study, we firstly identified NEK2, located at +1q32‐q33, late event pathogenesis, stage III‐IV paired sequential recurrent patients with by immunohistochemistry. Furthermore,...
Due to the low efficacy rates, effective biomarkers are desperately needed determine populations of advanced esophageal squamous cell carcinoma (ESCC) that may benefit from immune checkpoint inhibitor (ICI) treatment. To explore relationship between IL-6 and cancer tumor microenvironment using online databases tissue microarrays investigate predictive role for immunotherapy in patients through clinical study data. RNA-seq datasets ESCC were obtained TCGA, cells was discovered TIMER 2.0...