A5100346417- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Insect and Arachnid Ecology and Behavior
- Algal biology and biofuel production
- Cellular transport and secretion
- Probiotics and Fermented Foods
- Plant-based Medicinal Research
- Inflammatory mediators and NSAID effects
- Gastrointestinal motility and disorders
- Bone Metabolism and Diseases
- Gut microbiota and health
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Rheumatoid Arthritis Research and Therapies
- Soybean genetics and cultivation
- thermodynamics and calorimetric analyses
Dartmouth College
2021-2025
Huazhong Agricultural University
2021-2025
Hubei University of Medicine
2022-2024
Chongqing Medical University
2024
Taihe Hospital
2024
Fudan University
2023
Zhongshan Hospital
2023
Union Hospital
2022
Huazhong University of Science and Technology
2022
Ocean University of China
2022
Recent interest has focused on the importance of nucleus and associated nucleoskeleton in regulating changes cardiac gene expression response to biomechanical load. Mutations genes encoding proteins inner nuclear membrane nucleoskeleton, which cause cardiomyopathy, also disrupt a biomechanically responsive program. Furthermore, mutations outer protein Nesprin 1 2 have been implicated cardiomyopathy. Here, we identify for first time role proteins, 2, Ablation both cardiomyocytes, but neither...
Circular RNAs (circRNAs) belong to a new type of endogenous non-coding RNA and plays key role in carcinogenesis. Circ-ZKSCAN1 (hsa_circ_0001727) has been proven be tumor-dependent circRNA. However, its non-small cell lung cancer (NSCLC) underreported.The expression patterns circ-ZKSCAN1 were determined using qRT-PCR NSCLC samples lines. Cell proliferation was examined utilizing the CCK-8 assay. migration invasion evaluated Transwell The combination miR-330-5p cells analyzed by pull-down...
Mitochondrial division is an important cellular process in both normal and pathological conditions. The dynamin GTPase Drp1 a central mitochondrial protein, driving constriction of the outer membrane (OMM). In mammals, OMM protein fission factor (Mff) key receptor for recruiting from cytosol to mitochondrion. Actin filaments are also recruitment activation. manner which Mff actin work together activation unknown. Here we show that oligomer (most likely trimer) dynamically associates...
Lung adenocarcinoma (LUAD), which is the most common subtype of non-small cell lung cancer, a leading course cancer-related mortality worldwide. Recently, circular RNA (CircRNAs) has become hot spot in cancer research because its important role tumorigenesis and development superior stability. This study aims to clarify circ-AASDH LUAD explore competitive endogenous mechanism.The circ-AASDH, miR-140-3p E2F transcription factor 7 (E2F7) mRNA expression levels were detected via qRT-PCR. CCK-8...
Background: As a type of non-coding RNA, circular RNAs (circRNAs) are considered to be functional molecules associated with human cancers. An increasing number circRNAs have been verified in malignant progression The circRNA, circFBXW7, has proven play an important role tumor proliferation and metastasis. However, whether circFBXW7 influences lung adenocarcinoma (LUAD) remains unclear.Methods: Quantitative real-time reverse transcriptase PCR (qRT-PCR) was used verify LUAD cell lines tissues....
Drp1 is a dynamin family GTPase required for mitochondrial and peroxisomal division. Oligomerization increases activity through interactions between neighboring domains. In cells, regulated by several factors including receptors, actin filaments, cardiolipin, phosphorylation at two sites: S579 S600. Commonly, of considered activating, while S600 inhibiting. However, direct effects on have not been investigated in detail. Here, we compare purified Drp1, using phosphomimetic mutants vitro...
Abstract Background The incidence of ovarian cancer ranks third among gynecologic malignancies, but the mortality rate first. Methods expression GAS5 is low in and associated with survival patients according to public databases. overexpression inhibited malignancy by affecting proliferation migratory abilities OVCAR3 A2780 cells. increased cell apoptosis, cells were blocked G1 phase as assessed flow cytometry. Results We found that hnRNPK was a potential target gene, which regulated...
Odorant binding proteins (OBPs) play an important role in insect peripheral olfactory systems and exploring the physiological function of OBPs could facilitate understanding insects' chemical communication. Here, functional analysis antenna-based NlugOBP8 from brown planthopper (BPH) Nilaparvata lugens (Stål) was performed both vitro vivo. Recombinant exhibited strong affinity to 13 out 26 rice plant volatiles form a stable complex with 9 them according fluorescence quenching experiments....
Circular RNA has been revealed as a potential biomarker in multiple malignancies. However, few studies have focused on its to be prognostic markers lung squamous cell carcinoma (LSCC). In this work, we aimed build model of resected LSCC based circular pyruvate dehydrogenase kinase 1 (circPDK1) and other clinicopathological factors.circPDK1 was identified via next-generation sequencing. Three hundred two cases tissue their adjacent normal tissues were obtained from medical centers divided...
Drp1 is a dynamin family GTPase that required for mitochondrial and peroxisomal division, in which it oligomerizes into ring constricts the underlying membrane GTP hydrolysis-dependent manner. Oligomerization increases activity through interactions between neighboring domains. In cells, regulated by several factors including receptors, actin filaments, cardiolipin, phosphorylation at two sites: S579 S600. Phosphorylation of widely regarded as activating, while S600 commonly considered...
Plantaricin Q7 is a broad-spectrum antimicrobial peptide produced by Lactobacillus plantarum Q7. The effects of plantaricin on Listeria monocytogenes and its biofilm were investigated. results showed that changed the cell membrane permeability integrity significantly. extracellular lactate dehydrogenase activity increased from 156.74 U/L to 497.62 U/L, K+ concentration was rapidly 0.02 g/L 0.09 g/L. Furthermore, flagellum motility reduced relative adhesion rate decreased about 30% after...
<b><i>Background:</i></b> Quorum sensing (QS), as the basis of bacterial cell-to-cell communication, is a promising approach to reduce incidence multidrug resistance. The objective this study was search for novel quorum inhibitors from plants and control detrimental infections. <b><i>Methods:</i></b> crude extracts <i>Ficus carica </i>and <i>Perilla frutescens</i> were examined their anti-QS properties. Powdered plant...
The aim of our study is to explore the involvement PPARα and PPARγ in Ang II-induced endothelial injury. We found that II significantly elevated oxidative stress HUVECs, causing apoptosis cellular impairment a time-dependent pattern. Activation either by docosahexaenoic acid (DHA) or rosiglitazone protected cells. Interestingly, more significant effect was observed when DHA were administrated together. Moreover, we this protection mediated through PI3K/Akt pathway. Our may help understand...
Odorant-binding proteins (OBPs) and chemosensory (CSPs), which are thought to play key roles in the olfactory recognition of insects, can be induced by odorants they recognize, but little is known about underlying regulatory mechanisms. Here, we found that NlOBP8 NlCSP10 coordinative chemoreception brown planthoppers (BPHs) volatile component linalool. Also, relative mRNA levels NlObp8 NlCp10 decreased upon exposure Further, homeotic protein distal-less (Dll), was also highly expressed...
Glycosyltransferases play a crucial role in various cancers. β1, 3-N-acetylglucosaminyltransferase 2, polylactosamine synthase, is an important member of the glycosyltransferase family. However, biological function and regulatory mechanism β3GNT2 esophageal carcinoma (ESCA) still poorly understood.The Cancer Genome Atlas Genotype-Tissue Expression databases were used for gene expression prognosis analysis. Quantitative real-time PCR, Western blot, immunohistochemistry performed to detect...
A central goal of synthetic biology is to apply successful principles that have been developed in electronic and chemical engineering construct basic biological functional modules, through rational design, build systems with predetermined functions. Here, we the reverse design principle networks synthesize a gene circuit executes semi‐log dose‐response, logarithmically linear sensing function, Escherichia coli cells. We first mathematically define object function then search for tri‐node...