A5081534658- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Natural product bioactivities and synthesis
- Catalytic Cross-Coupling Reactions
- Kruppel-like factors research
- Protease and Inhibitor Mechanisms
- Bone Metabolism and Diseases
- Wnt/β-catenin signaling in development and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Catalytic Alkyne Reactions
- Ovarian cancer diagnosis and treatment
- Protein Hydrolysis and Bioactive Peptides
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Synthesis and Catalytic Reactions
- Bone and Dental Protein Studies
- Asymmetric Hydrogenation and Catalysis
- Phytochemistry and Biological Activities
Yangzhou University
2021-2023
Southwest University
2019-2022
Qingdao University
2019-2022
China Pharmaceutical University
2018-2021
Guangxi University
2014-2021
ORCID
2021
Guangxi University of Chinese Medicine
2014-2021
Chongqing Medical University
2003-2017
China Agricultural University
2013
University of South China
2010
An asymmetric organocatalytic remote 1,10-addition of alkynyl indole imine methides generated in situ from α-(6-indolyl) propargylic alcohols with thiazolones has been developed for the first time, affording axially chiral tetrasubstituted allenes featuring vicinal sulfur-containing quaternary carbon stereocenters high yields excellent stereoselectivities. The representative scale-up reaction and transformations 1,10-adduct were examined. mechanism was expounded by control experiments DFT...
A chiral phosphoric acid-catalyzed enantioselective 1,6-conjugate addition of thiolacetic acid to alkynyl indole imine methide <italic>in situ</italic> formed from α-(3-indolyl) propargylic alcohol has been established.
Pu-erh ripen tea becomes popular worldwide owing to its unique taste and aroma. In the present study, volatile compounds from were extracted using a solvent assisted flavor evaporation (SAFE) analyzed with gas chromatography-mass spectrometry (GC-MS) chromatography olfactometry (GC-O). Results demonstrated that 58 major 24 aroma active substances of identified by GC-MS GC-O analysis. Among identified, methoxyphenyl considered as dominate in tea. Further investigation showed 6 methoxybenzenes...
The diastereoselective and enantioselective direct vinylogous Michael addition of γ-substituted β,γ-unsaturated γ-lactones to 2-arylidene-<italic>N</italic>-tosylbenzofuran-3(2<italic>H</italic>)-imines has been achieved with the aid a quinine-derived squaramide.
Arginine-specific ADP-ribosytransferases 1 (ART1) is able to modify the arginine of specific proteins by mono-ADP-ribosylation. We previously reported that expression ART1 in human colon adenocarcinoma tissues was higher than adjacent tissues. Herein, we primarily revealed could regulate epithelial-mesenchymal transition (EMT) and, therefore, development carcinoma. In CT26 cells, which overexpressed lentiviral transfection, following were promoted: alterations spindle-like non-polarization,...
Diboron-mediated rhodium-catalyzed transfer hydrogenation of functionalized arenes is reported. In addition to good functional group tolerance, the reaction features operational simplicity and controllable chemoselectivity. The general applicability this procedure demonstrated by selective a range arenes, including benzenes, biphenyls, polyaromatics.
Gallic acid (GA) and its derivatives are anti-inflammatory agents reported to have potent effects on Osteoarthritis (OA) treatment. Nonetheless, it is generally accepted that the therapeutic effect biocompatibility of GA much weaker than esters due high hydrophilicity. The OA could be improved if certain structural modifications were made increase hydrophobicity. In this study, a novel sulfonamido-based gallate was synthesized by bonding sulfonamide with GA, biological evaluations...
A palladium-catalyzed alkenylation involving remote δ-position C(alkenyl)-H activation of cycloalkenes reacting with electron-deficient alkenes is described. This method features excellent site selectivity and stereoselectivity to efficiently afford only E-selective highly substituted 1,3-diene derivatives extra-ligand-free good functional group tolerance including estrone free N-H tryptamine under weakly alkaline conditions. Mechanistic studies suggest that picolinamide as a bidentate...
// Feng Ling 1, * , Yi Tang Ming Li 1 Qing-Shu Xian Lian Yang Wei Zhao Cong-Cong Jin Zhen Zeng Chang Liu Cheng-Fang Wu Wen-Wen Chen Xiao Lin Ya-Lan Wang and Michael D. Threadgill 2 Department of Pathology, Molecular Medicine Cancer Research Center, Chongqing Medical University, Chongqing, China Pharmacy Pharmacology, University Bath, UK are co-first authorship Correspondence to: Wang, email: wangyalan074@126.com Keywords: site mono-ADP-ribosylation, histone modification, colon carcinoma,...
Abstract Controllable synthesis of a variety allenic alcohols and 2,5‐dihydrofurans by rhodium(I)‐catalyzed arylative transformations propargylic diols is reported. The hydroxorhodium catalyst was found to play dual role: it catalyzed the arylation/dehydroxylation reaction afford alcohols, besides, could convert cationic rhodium species in situ, which intramolecular hydroalkoxylation form dihydrofurans. Remarkably, generation dependent on arylboron reagent used. Thus, controllable achieved...
Effective treatments for osteoporosis remain fairly elusive; however, studies have reported that antioxidants may aid in the maintenance of reactive oxygen species at a favorable level, order to prevent osteoporosis. Gallic acid (GA) and its derivatives are potent antioxidative anti‑inflammatory agents affect several biochemical pharmacological pathways; GA is slightly cytotoxic suppresses cell proliferation. The present study modified by introduction sulfonamide, obtain novel compound known...
A diboron‐mediated rhodium‐catalysed transfer hydrogenation system using water as the hydrogen donor is developed. In addition to a series of alkenes with good functional group tolerance, this rhodium‐based catalytic also effectively reduces aldehydes and ketones. plausible mechanism involving Rh I ‐catalysed generation 0 proposed for reaction.
Tissue engineering encapsulated cells such as chondrocytes in the carrier matrix have been widely used to repair cartilage defects. However, chondrocyte phenotype is easily lost when are expanded vitro by a process defined "dedifferentiation". To ensure successful therapy, an effective pro-chondrogenic agent necessary overcome obstacle of limited cell numbers restoration process, and dedifferentiation prerequisite. Gallic acid (GA) has treatment arthritis, but its biocompatibility inferior...
Purpose: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention osteoporosis through maintenance reactive oxygen species (ROS) at a favorable level.Materials and Methods: In this study, novel antioxidant, namely 3,4,5-Trihydroxy-N-[4-(5-hydroxy-6-methoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-benzamide (ZXHA-TC) was synthesized from gallic acid sulfadimoxine.Its effect osteoblast metabolism investigated via detection cell proliferation, viability,...
In China, western blot (WB) is the recommended procedure for diagnosis of HIV infection. However, this technique time consuming and labor intensive, its complexity restricts wide application in resource-limited regions. The aim study was to evaluate efficacy a dry blood spots (DBS)–urine paired enzyme-linked immunosorbent assay (ELISA) test, instead WB, antibody detection. Plasma, DBS, urine samples were collected from 1213 subjects different populations. Two diagnostic testing strategies...
To investigate the relationship of poly(ADP-ribose)glycohydrolase(PARG) with poly (ADP-ribose) polymerase(PARP), vascular endothelial growth factor (VEGF) and basic fibroblast factor(b-FGF) in colorectal carcinoma(CRC). Immunohistochemical analysis was used to detect PARG, PARP, VEGF b-FGF human carcinoma. Flow cytometry PARG PARP murine CT26 cell line. Gallotannin (GLTN) served as inhibitor. The individual positive rates were 55.81%(24/43), 97.67%(42/43), 79.07%(34/43) 81.40%(35/43),...
Abstract An approach to preparing enynyl‐aryl ethers from phenols and phenylacetylenes is described. This method without extra ligands, overcoming the favored Glaser‐Hay dimerization of alkyne, features a wide substrate scope (38 examples including endofolliculina indole) merits high atom step economy, good regio‐ stereoselectivity ( Z‐ isomers major) in moderate isolated yields. Mechanistic studies show that reaction enabled by distinctive copper/iodide tandem catalysis. magnified image
Numerous antioxidants exhibit antiarthritic effects due to their inhibitory effect on inflammatory factors. Certain antioxidants, such as protocatechuic acid (PCA) and its analogs, have been reported be effective in the treatment of arthritis. However, PCA chondro-protection may alleviated induction apoptosis, has demonstrated stomatocytes. To clearly determine biological cellular metabolism rabbit articular chondrocytes vitro, examinations cytotoxicity, proliferation morphology were...
Abstract We report a challenging copper‐catalyzed C formyl −H arylation of salicylaldehydes with arylboronic acids that involves unique salicylaldehydic copper species differ from reported rhodacycles and palladacycles. This protocol has high chemoselectivity for the bond compared to phenolic O−H involving catalysis under reaction temperatures. approach is compatible wide range salicylaldehyde acid substrates, including estrone carbazole derivatives, which leads corresponding products....
Abstract Background Intervertebral disc degeneration (IDD) is a major cause of lower back pain. This study aimed at exploring the effects histone deacetylase 4 (HDAC4) and its upstream downstream signaling molecules on IDD development. Methods A murine model was established by inducing needle puncture injury to vertebrate, whereupon we isolated transfected nucleus pulposus (NP) cells. Disc height index (DHI) mice determined X-ray tomography, while pain experienced evaluated mechanical...