A5101501416- CAR-T cell therapy research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Hepatitis C virus research
- Retinal and Macular Surgery
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Animal Disease Management and Epidemiology
- Acute Myeloid Leukemia Research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Traumatic Ocular and Foreign Body Injuries
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Nanowire Synthesis and Applications
- Disaster Response and Management
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
Southern Medical University
2011-2023
Chengdu University of Traditional Chinese Medicine
2011-2021
Sichuan Agricultural University
2018-2021
Shandong First Medical University
2021
National Health and Family Planning Commission
2021
Second Military Medical University
2012-2020
Changhai Hospital
2020
The University of Texas MD Anderson Cancer Center
2012-2019
State Key Laboratory of Respiratory Disease
2018
Guangzhou Medical University
2018
Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to adoptive immunotherapy based on second generation CAR (designated CD19RCD28) that signals through CD28 and CD3-ζ endodomain. are electroporated with DNA plasmids from the Sleeping Beauty (SB) transposon/transposase system express this CAR. Stable integrants genetically modified can then be retrieved when co-cultured designer...
Immune dysregulation and altered T‐cell hemostasis play important roles in the pathogenesis of myelodysplastic syndromes (MDS). Recent studies suggest an increased risk MDS among patients with autoimmune diseases. Here, we investigated prevalence diseases patients, comparing characteristics outcomes those without From our study group 1408 391 (28%) had disease, hypothyroidism being most common type, accounting for 44% ( n = 171) (12% all analyzed). Other ≥5% included idiopathic...
Chronic lymphocytic leukemia (CLL) cells express high levels of CD44, a cell-surface glycoprotein receptor for hyaluronic acid. We found that humanized mAb specific CD44 (RG7356) was directly cytotoxic B cells, but had little effect on normal cells. Moreover, RG7356 could induce CLL expressed the zeta-associated protein 70 kDa (ZAP-70) to undergo caspase-dependent apoptosis, independent complement or effector The this not mitigated when were cocultured with mesenchymal stromal (MSCs) acid...
Duck hepatitis A virus type 1 (DHAV-1) is one of the most harmful pathogens in duck industry. The infection adult ducks with DHAV-1 was previously shown to result transient cytokine storms their kidneys. To understand how impacts host liver, we conducted animal experiments virulent CH strain and attenuated CH60 commercial vaccine strain. Visual observation standard hematoxylin eosin staining were performed detect pathological damage viral copy numbers expression liver evaluated by...
The development of vaccination and novel therapy for hepatitis C virus (HCV) has been hampered by the lack suitable small-animal models. GB B (GBV-B), closely related to HCV, causes viral in common marmosets (Callithrix jacchue jacchus) might represent an attractive surrogate model HCV infection. However, differences exist between GBV-B spite a short genetic distance two viruses. Here we report infected with HCV/GBV-B chimeras containing structural genes coding either whole core envelope...
The emergence of duck tembusu virus (DTMUV), a new member the Flavivirus genus, has caused great economical loss in poultry industry China. Since outbreak and spread DTMUV is hard to control clinical setting, an efficient low-cost oral delivery DNA vaccine SL7207 (pVAX1-C) based on capsid protein was developed evaluated this study. antigen expressed from (pVAX1-C), both vitro vivo. humoral cellular immune responses vivo were observed after immunization with vaccine. High titers specific...
Prevention and control of childhood diarrhea is a global priority. We conducted case-control study in Shanghai.We prospectively recruited diarrheal children an outpatient setting. Nondiarrheal controls were individually matched to cases. Rotavirus, norovirus bacterial pathogens examined. Clinical epidemiologic data obtained at enrollment follow-up.Potential identified 680 cases rotavirus (19.0% vs. 1.3%), (13.4% 4.7%), nontyphoidal Salmonella (9.3% 1.9%), enteropathogenic Escherichia coli...
In China, western blot (WB) is the recommended procedure for diagnosis of HIV infection. However, this technique time consuming and labor intensive, its complexity restricts wide application in resource-limited regions. The aim study was to evaluate efficacy a dry blood spots (DBS)–urine paired enzyme-linked immunosorbent assay (ELISA) test, instead WB, antibody detection. Plasma, DBS, urine samples were collected from 1213 subjects different populations. Two diagnostic testing strategies...
Hepatitis C virus (HCV) vaccines are an urgent need to prevent hepatitis and its further progression of hepatocellular carcinoma. Since the promising T cell based chimpanzee adenovirus modified vaccinia Ankara vectorial HCV were failed in clinical phase II trial, vaccine designs improve protection efficacy combination cellular humoral immunity have been hypothesized against multi-genotypic HCV.
Duck enteritis virus (DEV) can successfully evade the host innate immune responses and establish a lifelong latent infection in infected host. However, study about how DEV escapes immunity is still deficient up to now. In this study, for first time, we identified viral protein VP16 by which obviously downregulate production of IFN- β duck embryo fibroblast (DEF). Our results showed that ectopic expression decreased (duIFN- ) promoter activation significantly inhibited mRNA transcription ....
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases in urology, which 50% men are infected at some point their lives. Type III CP/CPPS complex and controversial all types prostatitis, highest incidence rate, uncertain efficacy, long-term treatment that affects patient's psychopathic symptoms, increases psychological burden patients. Psychological intervention for patients with CP/CPPS, difficult to treat drugs physics, can effectively improve...