A5010824709- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Functional Brain Connectivity Studies
- Advanced X-ray and CT Imaging
- Advanced Neuroimaging Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Growth Hormone and Insulin-like Growth Factors
- Teratomas and Epidermoid Cysts
- Metabolomics and Mass Spectrometry Studies
- CRISPR and Genetic Engineering
- Cutaneous Melanoma Detection and Management
- Bioinformatics and Genomic Networks
- Pituitary Gland Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Congenital heart defects research
- Ferroptosis and cancer prognosis
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Bone Metabolism and Diseases
Fudan University
2019-2023
Nanjing Medical University
2023
State Key Laboratory of Genetic Engineering
2019-2023
Southern Medical University
2021-2023
Nanfang Hospital
2021-2023
Jiangsu Province Hospital
2023
Shanghai Institute of Planned Parenthood Research
2022
Air Force Medical University
2013
82th Hospital of Pla
2012
Abstract The genetic etiology and underlying mechanism of autism spectrum disorder (ASD) remain elusive. SHANK family genes ( SHANK1/2/3 ) are well known ASD-related genes. However, little is about how missense mutations contribute to ASD. Here, we aimed clarify the molecular multilevel neuropathological features induced by Shank1 in knock-in (KI) mice. In this study, sequencing SHANK1 gene a cohort 615 ASD patients 503 controls, identified an ASD-specific recurrent mutation, c.2621 G > A...
Abstract Although the diagnoses based on phenomenology have many practical advantages, accumulating evidence shows that schizophrenia and autism spectrum disorder (ASD) share some overlap in genetics clinical presentation. It remains largely unknown how ASD-associated polygenetic risk contributes to pathogenesis of schizophrenia. In present study, we calculated high-resolution ASD polygenic scores (ASD PRSs) selected optimal ten PRS with minimal P values association analysis PRSs, assess...
Background Schizophrenia is considered a polygenic disorder. People with schizophrenia and those genetic high risk of (GHR) have presented similar neurodevelopmental deficits in hemispheric asymmetry. The potential associations between abnormalities schizophrenia-related genes both GHR remains unclear. Aims To investigate the shared specific alternations to structural network people GHR. And identify an association vulnerable alternation genes. Method A total 97 participants schizophrenia,...
Synaptic pathology may be one of the cellular substrates underlying autism spectrum disorder (ASD). ZNF804A is a transcription factor that can affect or regulate expression many candidate genes involved in ASD. It also localizes at synapses and regulates neuronal synaptic morphology. So far, few reports have addressed possible associations between polymorphisms This study aimed to investigate whether genetic variants contribute ASD susceptibility its pathological role disorder. We analyzed...
<title>Abstract</title> Objectives This study aimed to explore the feasibility of reducing contrast medium (CM) volume, improving image quality and diagnostic accuracy using variable helical pitch (VHP) scanning for patients with lower extremity arterial disease (LEAD). Materials Methods Eighty who underwent CT angiography (CTA) were prospectively enrolled randomly assigned either VHP group (n = 40) or conventional 40). Quantitative parameters qualitative scores compared between two groups....
Autism spectrum disorder (ASD) is a neurodevelopmental characterized by core symptoms that consist of social deficits and repetitive behaviors. Unfortunately, no effective medication available thus far to target the ASD, since pathogenesis remains largely unknown. To investigate in we constructed Shank1 P1812L-knock-in (KI) mice corresponding recurrent ASD-related mutation, SHANK1 P1806L, achieve construct validity face validity. P1812L-KI heterozygous (HET) presented with behaviors without...
Immunotherapy is a promising treatment for advanced colorectal cancers (CRCs). However, immunotherapy resistance remains common problem. Immunogenic cell death (ICD), form of regulated death, induces adaptive immunity, thereby enhancing anti-tumor immunity. Research increasingly suggests that inducing ICD avenue cancer and identifying ICD-related biomarkers CRCs would create new direction targeted therapies. Thus, this study used bioinformatics to address these questions prognostic...
To analyze recurrence and progression patterns of primary central nervous system lymphoma (PCNSL) in patients without whole brain radiotherapy (WBRT) assess the value WBRT PCNSL treatment.This retrospective single-center study included 27 with PCNSL, who experienced recurrence/progression after achieving complete remission (CR), partial remission, or stable disease following initial treatments chemotherapy but WBRT. The were followed up regularly treatment for efficacy assessment. By...
Abstract BackgroundBefore the introduction of chemotherapeutic agent methotrexate, radiotherapy (RT) and steroids have been sole, first-line treatment primary central nervous system lymphoma (PCNSL). With application role RT in PCNSL has challenged. MethodsWe performed observation analysis on 2,486 patients between 1988 2016 from Surveillance, Epidemiology End Results (SEER) database. Propensity score matching (PSM) was employed to ensure well-balanced characteristics two groups who received...