A5063090771- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Neurobiology and Insect Physiology Research
- Genetics, Bioinformatics, and Biomedical Research
- Olfactory and Sensory Function Studies
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Biochemical Analysis and Sensing Techniques
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
Shiseido Group (Japan)
2022-2023
University of California, San Diego
2015-2016
University of Toyama
2008-2015
Gene Therapy Laboratory
2013-2015
Mediator is a large complex containing up to 30 subunits that consist of four modules each: head, middle, tail and CDK/Cyclin. Recent studies have shown CDK8, subunit the CDK/Cyclin module, one key mediates its pivotal roles in transcriptional regulation. In addition CDK19 was identified human with great deal similarity CDK8 but conserved only vertebrates. Previously, we reported could form complexes independent CDK8. To further investigate vivo activities complexes, used luciferase assay...
Mediator is an essential transcriptional cofactor of RNA polymerase II (Pol II) in eukaryotes. This a large complex containing up to 30 subunits and consisting four modules: head, middle, tail, CDK/Cyclin. Generally, connects regulators, cofactors, chromatin remodellers, with the pre-initiation provide platform for assembly these factors. Many previous studies have revealed that CDK8, subunit CDK/Cyclin module, one key mediating pivotal roles regulation. In addition CDK11 conserved among...
The Mediator complex (Mediator) plays key roles in transcription and functions as the nexus for integration of various transcriptional signals. Previously, we screened cyclin-dependent kinase (CDK)-interacting factors identified three proteins related to chromatin regulation. One them, SUZ12 is required both stability activity Polycomb Repressive Complex 2 (PRC2). PRC2 primarily suppresses gene expression through histone H3 lysine 27 trimethylation, resulting stem cell maintenance...
Olfactory receptors (ORs) are expressed in many tissues and have multiple functions. However, most studies focused on individual ORs. Here, we aimed to conduct a comprehensive meta-transcriptome analysis of OR gene expression human by using open-source tools search large, publicly available genotype-tissue (GTEx) data set. Analysis RNA-seq from GTEx revealed that patterns were tissue-dependent, identified distinct sets ORs highly 12 tissues, involving 97 total. Among them, OR5P2, OR5P3...
The Mediator complex has been thought as a key regulatory of RNA polymerase II (Pol II) and it known bivalent, positive negative, transcriptional regulator. complexes were reported to form at least two subtypes, large‐Mediator small‐Mediator, depending on those subunit compositions. In previous studies, act negatively small‐Mediator positively in transcription. Compared its roles activation, little repression. Here I show novel mechanisms the repression C/EBPβ target genes. To study...