A5102134228- Ion channel regulation and function
- RNA Research and Splicing
- RNA modifications and cancer
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Cellular Mechanics and Interactions
- Adsorption and biosorption for pollutant removal
- Nanomaterials for catalytic reactions
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Ion Channels and Receptors
- Receptor Mechanisms and Signaling
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Traditional Chinese Medicine Analysis
- Environmental remediation with nanomaterials
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
China National Petroleum Corporation (China)
2025
Shenzhen University
2017-2024
Shenzhen University Health Science Center
2019-2023
Dalian University of Technology
2005-2019
University of California, San Diego
2013-2016
Peking University
2004-2011
Center for Life Sciences
2011
Beijing National Laboratory for Molecular Sciences
2007
Southern Medical University
2004
Cancer theranostics based on glucose oxidase (GOx)-induced starvation therapy has got more and attention in cancer management.Herein, GOx armed manganese dioxide nanosheets (denoted as MNS-GOx) were developed nanotheranostic agent for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided self-oxygenation/hyperthermia dually enhanced therapy.The nanomaterials with different morphologies (such nanoflowers, nanowires) synthesized by a biomimetic approach using melanin...
AimsThe cardiac ryanodine receptor (RyR) Ca2+ release channel homotetramer harbours ∼21 potentially redox-sensitive cysteine residues on each subunit and may act as a sensor for reactive oxygen species (ROS), linking ROS homeostasis to the regulation of signalling. In myocytes, arrayed RyRs or units are packed in close proximity mitochondria, primary source intracellular production. The present study investigated whether how mitochondria-derived regulate spark activity intact myocytes.
Heart failure is characterized by the transition from an initial compensatory response to decompensation, which can be partially mimicked transverse aortic constriction (TAC) in rodent models. Numerous signaling molecules have been shown part of program, but relatively little known about decompensation that leads heart failure. Here, we show TAC potently decreases RBFox2 protein mouse heart, and cardiac ablation this critical splicing regulator generates many phenotypes resembling those...
This Research Article described a facile one-step method to prepare reticulated N-doped carbonaceous submicron spheres. Through simple aerosol-assisted technology, glucosamine sulfate used as carbon source was aerosolized and carbonized functionalized The electrostatic attraction between protonated amino groups in the aerosol droplets induced self-assembly led formation of reticular structure, avoiding use templates. Compared bare materials produced from glucose, spheres exhibit higher...
KChIP2 (K+ channel interacting protein) is the auxiliary subunit of fast transient outward K+ current ( Ito,f) in heart, and insufficient expression induces Ito,f downregulation arrhythmogenesis cardiac hypertrophy. Studies have shown muscle-specific mitsugumin 53 (MG53) has promiscuity function context normal diseased heart. This study investigates possible roles MG53 regulation Ito,f, arrhythmogenic potential hypertrophy.MG53 manipulated by genetic ablation mice adenoviral overexpression...
There is increasing evidence that vascular endothelial growth factor (VEGF) contributes to inflammation independent of its angiogenic functions. Targeting some the components in Weibel-Palade bodies (WPBs) effectively inhibits VEGF-induced inflammation, but little known about how VEGF regulates WPB exocytosis. In this study, we showed receptor-2 (VEGFR2), not VEGFR1, responsible for release von Willebrand (vWF), a major marker WPBs. This good contrast VEGF-stimulated interleukin-6 from...
Heart performance relies on highly coordinated excitation-contraction (EC) coupling, and defects in this critical process may be exacerbated by additional genetic and/or environmental insults to cause eventual heart failure. Here we report a regulatory pathway consisting of the RNA binding protein RBFox2, stress-induced microRNA miR-34a, essential EC coupler JPH2. In pathway, initial cardiac diminish RBFox2 expression, which induces transcriptional repression elevated miR-34a targets Jph2...
ABSTRACT In this study, we employed high‐throughput all‐atom molecular dynamics simulations to calculate the adsorption properties of various carbon chain lengths and branching forms phosphate ester anions on metal surfaces. Two layers concurrent parallel algorithms were applied in calculations. The results indicate that both length influence magnitude free energy. Longer chains result larger energy, while more complex lead smaller analysis suggests complexity have dual effects. As...
With the gradual maturation of optically pumped magnetometer (OPM) technology, use OPMs to acquire weak magnetocardiography (MCG) signals has started gain widespread application. Due complexity magnetic environments, MCG are often subject interference from various unknown sources. Independent component analysis (ICA) is one most widely used methods for blind source separation. However, in practical applications, numbers retained components and filtering selected manually, relying on...
Axon injury triggers dramatic changes in gene expression. While transcriptional regulation of injury-induced expression is widely studied, less known about the roles RNA binding proteins (RBPs) post-transcriptional during axon regeneration. In C. elegans CELF (CUGBP and Etr-3 Like Factor) family RBP UNC-75 required for Using crosslinking immunoprecipitation coupled with deep sequencing (CLIP-seq) we identify a set genes involved synaptic transmission as mRNA targets UNC-75. particular, show...
In vivo real-time monitoring gastric acid is of great importance for diagnosis and treatment gastrointestinal diseases. Herein, we synthesized a pH-responsive photoacoustic (PA) nanoprobe (denoted as LET-4) based on near-infrared (NIR) dye (IR1061) in imaging (PAI) living subjects. the acidic condition, protonated LET-4 has strong absorbance peak at 808 nm, followed by PA signal output nm. The PA808 pH 3 3.45-fold higher than 7. More importantly, could monitor secretion assessment animal...
Heart failure is the final stage of various cardiovascular diseases and seriously threatens human health. Increasing mediators have been found to be involved in pathogenesis heart failure, including RNA binding protein RBFox2. It participates multiple aspects regulation cardiac function plays a critical role process failure. However, how RBFox2 itself regulated remains unclear. Here, we dissected transcriptomic signatures, mRNAs miRNAs, mouse model after TAC surgery. A global analysis showed...
Small non-translated regulatory RNAs control plenty of bacterial vital activities. The small RNA GcvB has been extensively studied, indicating the multifaceted roles beyond amino acid metabolism. However, few reported GcvB-dependent regulation in minimal medium. Here, by applying a high-resolution RNA-seq assay, we compared transcriptomes wild-type Escherichia coli K-12 strain and its gcvB deletion derivative grown medium identified putative targets responding to GcvB, including flu,...
A facile method to synthesize iron–carbon composites, which exhibit synergistic adsorption and reaction towards a more efficient removal of Cr(<sc>vi</sc>).