A5042690169- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Plant Pathogenic Bacteria Studies
- CRISPR and Genetic Engineering
- Plant-Microbe Interactions and Immunity
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Insect-Plant Interactions and Control
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Virus-based gene therapy research
- Transgenic Plants and Applications
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Plant Molecular Biology Research
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- RNA Research and Splicing
- Plant tissue culture and regeneration
- Antioxidant Activity and Oxidative Stress
- Circular RNAs in diseases
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
North China University of Technology
2024-2025
Shandong Agricultural University
2014-2024
Nanjing Normal University
2022-2024
Tsinghua University
2024
PetroChina Southwest Oil and Gas Field Company (China)
2024
Tianjin Medical University
2019-2023
Tianjin Medical University Eye Hospital
2019-2023
Chaohu Hospital of Anhui Medical University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Qingdao University
2020-2022
Celastrol was recently identified as a potential novel treatment for obesity. However, the effect of on nonalcoholic fatty liver disease (NAFLD) remains elusive. The aim this study is to evaluate role in NAFLD.Functional studies were performed using wild-type C57BL/6J (WT) mice and specific Sirt1-deficient (LKO) mice. molecular mechanism explored primary mouse hepatocytes.When WT receiving high-fat diet (HFD) treated with Celastrol, reductions body weight, subcutaneous visceral fat content,...
Swine enteric viruses are a major cause of piglet diarrhea, causing devastating impact on the pork industry. To further understand molecular epidemiology and evolutionary diversity swine viruses, we carried out epidemiological investigation (PEDV, PDCoV, PoRVA, TGEV) 7107 samples collected from pig farms in south-central China. The results demonstrated that PEDV is predominant pathogen its infection occurs mainly relatively cold winter spring Hunan Hubei provinces. positive rate showed an...
Cucurbits are economically important crops worldwide. The genomic data of many cucurbits now available. However, functional analyses cucurbit genes and noncoding RNAs have been impeded because genetic transformation is difficult for cucurbitaceous plants. Here, we developed a set tobacco ringspot virus (TRSV)-based vectors gene microRNA (miRNA) function studies in cucurbits. A TRSV-based expression vector could simultaneously express GREEN FLUORESCENT PROTEIN (GFP) heterologous viral...
Trichomes, the hair-like structures located on aerial parts of most vascular plants, are associated with a wide array biological processes and affect economic value certain species. The involved in unicellular trichome formation have been well-studied Arabidopsis (Arabidopsis thaliana). However, our understanding morphological changes underlying molecular multicellular development is limited. Here, we studied dynamic developmental glandular nonglandular cucumber (Cucumis sativus L.) divided...
Hepatocellular carcinoma (HCC) is notorious for its poor prognosis. Previous studies identified several N6-methyladenosine (m6A)-related genes that play key roles in the initiation and progression of HCC patients. In particular, RNA methylation regulator ZC3H13 could be a candidate as novel biomarker therapeutic target hepatocellular carcinoma. HCC, low expression was reported, but molecular reason unclear. this study, we performed pan cancer analysis prognosis using The Cancer Genome Atlas...
Tomato brown rugose fruit virus (ToBRFV) is a novel tobamovirus firstly reported in 2015 and poses severe threat to the tomato industry. So far, it has spread 10 countries America, Asia, Europe. In 2019, ToBRFV was identified Shandong Province (ToBRFV-SD), China. this study, shown that ToBRFV-SD induced mild mosaic blistering on leaves, necrosis sepals pedicles, deformation, yellow spots, necrotic lesions fruits. distinct symptoms plants of tomato, Capsicum annumm, Nicotiana benthamiana,...
Abstract Tomato cultivars containing the Tm‐2 2 resistance gene have been widely known to resist tobacco mosaic virus (TMV) and tomato virus. brown rugose fruit (ToBRFV), a new emerging tobamovirus, can infect plants carrying gene. However, virulence determinant of ToBRFV that overcomes conferred by remains unclear. In this study, we substituted movement protein (MP) encoding sequences between TMV infectious clones conducted infectivity assays. The results showed MP was for transgenic...
Eukaryotic translation initiation factor 4E (eIF4E), which plays a pivotal role in initiating eukaryotic organisms, is often hijacked by the viral genome-linked protein to facilitate infection of potyviruses. In this study, we found that naturally occurring amino acid substitution D71G eIF4E widely present potyvirus-resistant watermelon accessions and disrupts interaction between papaya ringspot virus-watermelon strain, zucchini yellow mosaic virus or virus. Multiple sequence alignment...
To investigate the interaction between blasting crack and circular hole with various offset distances in PMMA, this study examined propagation arrest mechanisms of utilizing a dynamic caustics experimental system. When distance (d) ≥ 8 mm, had negligible effect on propagation. d = 6 velocity mode I stress intensity factor propagating near were significantly reduced. The exerted notable hindering crack, however, it did not completely initially approaches subsequently moves away from hole. ≤ 4...
The intercellular movement of plant viruses requires both viral and host proteins. Previous studies have demonstrated that the frame-shift protein P3N-PIPO (for encoded by open reading frame [ORF] containing 5'-terminus P3 a +2 ORF called Pretty Interesting Potyviridae embedded in P3) CYLINDRICAL INCLUSION (CI) proteins were required for potyvirus cell-to-cell movement. Here, we provide genetic evidence showing Tobacco vein banding mosaic virus (TVBMV; genus Potyvirus) mutant carrying...
Abstract Tobacco mosaic virus (TMV; genus Tobamovirus ) is one of the most prevailing pathogens that seriously affects quality and yield tobacco ( Nicotiana tabacum leaves. Cross-protection using mild strains a potential strategy for biological prevention plant viral diseases. Complementary mutations in attenuated may cause ones to suddenly evolve into virulent strains, which limits application cross-protection practice. To data there has been no study on engineering complementary mutation...
Chloroplast-bound vesicles are key components in viral replication complexes (VRCs) of potyviruses. The potyviral VRCs induced by the second 6 kDa protein (6K2) and contain at least RNA nuclear inclusion b. To date, no chloroplast has been identified to interact with 6K2 involve potyvirus replication. In this paper, we showed that Photosystem II oxygen evolution complex Nicotiana benthamiana (NbPsbO1) was a interacting Tobacco vein banding mosaic virus (TVBMV; genus Potyvirus) present VRCs....
Chloroplasts play an indispensable role in the arms race between plant viruses and hosts. Chloroplast proteins are often recruited by to support viral replication movement. However, mechanism which chloroplast regulate potyvirus infection remains largely unknown. In this study, we observed that Nicotiana benthamiana ribosomal protein large subunit 1 (NbRPL1), a protein, localized chloroplasts via its N-terminal 61 amino acids (transit peptide), interacted with tobacco vein banding mosaic...
Abstract Tomato mottle mosaic virus (ToMMV) poses a threat to production and quality of tomato fruits. The Tm-2 2 gene confers resistance some tobamoviruses by recognizing viral movement proteins. However, -mediated against ToMMV is not well known. Here, we found that could infect wild-type but transgenic Nicotiana benthamiana plants also cultivar Moneymaker resistant Jili with homozygous . Chimeric ToBRFV−MP swapped MP brown rugose fruit systemically N. cultivars plants. Further, transient...
Sugarcane mosaic virus (SCMV; genus Potyvirus) induces maize dwarf disease that has caused serious yield losses of in China. Cross-protection is one the efficient strategies to fight against severe strains. Although many mild strains have been identified, spontaneous mutation challenging problems affecting their application cross-protection. In this study, we found substitution cysteine (C) at positions 57 or 60 zinc finger-like motif HC-Pro with alanine (A; C57A C60A) significantly reduced...