A5100551589- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral Infections and Immunology Research
Hubei Academy of Agricultural Sciences
2022-2024
Animal Science Research Institute
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Swine enteric viruses are a major cause of piglet diarrhea, causing devastating impact on the pork industry. To further understand molecular epidemiology and evolutionary diversity swine viruses, we carried out epidemiological investigation (PEDV, PDCoV, PoRVA, TGEV) 7107 samples collected from pig farms in south-central China. The results demonstrated that PEDV is predominant pathogen its infection occurs mainly relatively cold winter spring Hunan Hubei provinces. positive rate showed an...
Since the large-scale outbreak of porcine epidemic diarrhoea (PED) in 2010, caused by genotype 2 (G2) variant virus (PEDV), pig farms China, even those vaccinated with G2b vaccine, have experienced infections from G2a variant, leading to significant economic losses. This study successfully isolated strain DY2020 positive small intestine contents (SICs) blind passage on Vero cells for four generations. The SICs were taken Daye, Hubei Province, China. biological characteristics identified...
The porcine reproductive and respiratory syndrome virus (PRRSV) causes a highly contagious disease in domestic swine. Signaling lymphocytic activation molecule family member 1 (SLAMF1) is costimulatory factor that involved innate immunity, inflammation, infection. Here, we demonstrate overexpression of the SLAMF1 gene inhibited PRRSV replication significantly reduced levels key signaling pathways, including MyD88, RIG-I, TLR2, TRIF, inflammatory factors IL-6, IL-1β, IL-8, TNF-β, TNF-α, IFN-α...