A5029714030- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- COVID-19 epidemiological studies
- HIV Research and Treatment
- Influenza Virus Research Studies
- Adolescent Sexual and Reproductive Health
- Hepatitis B Virus Studies
- Sex work and related issues
- Vaccine Coverage and Hesitancy
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Syphilis Diagnosis and Treatment
- Data-Driven Disease Surveillance
- Reproductive tract infections research
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- COVID-19 and Mental Health
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- COVID-19 Pandemic Impacts
- Mycobacterium research and diagnosis
- Genital Health and Disease
Chinese University of Hong Kong
2016-2025
Hong Kong Jockey Club
2021-2025
Prince of Wales Hospital
2010-2023
National Centre for Infectious Diseases
2013-2022
Taipei Tzu Chi Hospital
2022
Department of Health
2022
University of Hong Kong
2018-2021
University of North Carolina at Chapel Hill
2016-2020
Queen Mary Hospital
2019
Stanley Foundation
2019
Hong Kong is an intermediate tuberculosis (TB) endemicity city dominated by reactivation diseases. A cross-sectional study on the clinical and epidemiologic data of newly diagnosed TB cases was conducted in such a setting, to examine association between ambient PM2.5 reactivation. After exclusion most likely resulting from recent infection, four distinct population phenotypes were delineated latent class analysis based their risk profiles (N = 2,153): 'Elderly male' (26%), 'Otherwise healthy...
In May 2015, South Korea reported its first case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in a 68-year-old man with history travel the East. presence secondary infections, an understanding transmission dynamics virus is crucial. The aim this study was to characterize chains MERS-CoV current Korean outbreak.Individual-level data from multiple sources were collected and used for epidemiological analyses.As July 14, 185 confirmed cases MERS have been outbreak. Three...
Syphilis control programs have been scaled up due to the substantial burden in China. We analyzed syphilis incidence according demographic, spatiotemporal, and economic factors. The increasing latent diagnoses declining congenital suggest effectiveness of scale-up screening. However, primary secondary cases persist, especially inland provinces.
Transmission dynamics of SARS-CoV-2 varied by the settings virus exposure. Understanding inter-relationship between exposure setting and transmission networks would provide a basis for informing public health control strategies.Surveillance clinical data from first wave COVID-19 outbreaks in Hong Kong were accessed. Twelve types differentiated - household, neighbourhood, eateries, entertainment, parties, shopping, personalised service, workplace, education, worship, healthcare, transport....
Background Chemsex engagement is known to be associated with higher-risk sexual behaviour, HIV and sexually transmitted infection (STI). To reduce risk, pre-exposure prophylaxis (PrEP) increasingly used in the men who have sex (MSM) community. This study aims examine interrelationship between chemsex PrEP use MSM. Methods a cross-sectional recruitment of MSM community Hong Kong. Participating were invited complete an online survey which included (experienced or naïve) use, history test...
ABSTRACT In the setting of high hepatitis B virus (HBV) endemicity, we studied cost‐effectiveness universal HBV screen‐and‐treat strategies for averting HBV‐related morbidity and mortality in Hong Kong, where diagnosis treatment coverages are low. An age–sex‐specific compartmental model 2000–2040 was developed, with incorporation population‐based screening targeting different age groups. With a one‐time programme 2025–2029, 3.6%–8.9% deaths could be averted. We evaluated primary‐care‐based...
Human immunodeficiency virus self-testing (HIVST) holds great promise for reaching high-risk key populations who do not access facility-based services. We sought to characterize unsupervised HIVST implementation among men have sex with in China.We conducted a nationwide online survey China. Eligible were at least 16 years, had anal man, and recent condomless sex. assessed benefits (first-time testing, increased testing frequency, confirmatory testing) potential harms (coercion, violence,...
Abstract The onset of the 2019–20 winter influenza season in Hong Kong coincided with emergence coronavirus disease epidemic neighboring mainland China. After widespread adoption large-scale social distancing interventions response to impending outbreak, ended abruptly a decrease low trough.
Using two early transmission chains in Hong Kong, the estimated R and k were 1.34 [95% credible interval (CrI): 0.94–2.19] 0.33 (95%CrI: 0.17–0.62), respectively, inferring 20.3% 12.7–29.6%) cases responsible for 80% of transmissions Omicron epidemic. Compared with BA.1, BA.2 had a greater superspreading potential.
Abstract Background Nirmatrelvir-ritonavir is currently not recommended in patients with an estimated glomerular filtration rate (eGFR) <30 mL/minute/1.73 m2. Methods To determine the safety profile and clinical virological outcomes of nirmatrelvir-ritonavir use at a modified dosage adults chronic kidney disease (CKD), prospective, single-arm, interventional trial recruited eGFR m2 on dialysis. Primary included profile, adverse/serious adverse events, events leading to drug...
Abstract Background Chronic hepatitis B virus (HBV) infection increases the risk of liver injury in patients who undergo antituberculosis treatment. It is uncertain whether antiviral treatment for HBV at time tuberculosis diagnosis would reduce injury. Methods We performed a population-level, retrospective, cohort study that involved all with tuberculosis–HBV coinfection treated public hospitals Hong Kong over 16-year period. Patients received were considered “patients on therapy.” A...
Regular HIV and sexually transmitted infection (STI) testing for men who have sex with (MSM) is an important means of prevention, the adoption which remains suboptimal in community.On hypothesis that engagement plays role sexual health monitoring, this study aimed to pilot-test internet-based STI self-sampling enhance MSM regular testing.This 1-year cohort was conducted on HIV-negative aged 18 years or older. A designated website set up enable participants make appointments baseline...
Background Advances in communication technology may affect networking pattern, thereby influencing the dynamics of sex partnership. The aim study is to explore impacts partner sourcing through internet and related channels on exposure risk sexually transmitted infections (STI) including HIV. Methods Using venue-based sampling, a cross-sectional questionnaire survey was conducted at saunas frequented by men having with (MSM) Hong Kong. Comparison made between MSM partners physical venues...
Chlamydia causes infertility and increases risk of HIV infection, population-based studies provide essential information for effective infection control prevention. This study examined trachomatis prevalence factors among a representative sample 18-49-year-old residents in Hong Kong.Census boundary map 412 constituency areas was used as primary sampling units to construct the frame and, residential buildings were randomly selected using geospatial modelling. A questionnaire on sexual...
Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune incorporating both count and CD4:CD8 ratio.Observational cohort study SETTING AND PARTICIPANTS: Clinical data from Chinese HIV-positive patients attending largest HIV service in Hong Kong who had been on HAART for ≥4 years were accessed.Optimal outcome was defined as a combination ≥500/μL ratio ≥0.8.A total 718...
Abstract Pre-exposure prophylaxis (PrEP) targeting high-risk men who have sex with (MSM) has been shown to be a cost-effective HIV control measure. However, the approach could challenge in low incidence places proportion of MSM. To examine impact PrEP such setting Asia, we developed an epidemic model and conducted cost-effectiveness analysis using empirical multicentre clinical sequence data from HIV-infected MSM Hong Kong, conjunction behavioural local Without PrEP, (per 100 person-years)...
There was a varied spatial distribution of reported syphilis cases across cities in South China. This study aims to identify and describe spatiotemporal clusters primary secondary (P/S) this region. Reported Guangdong Province, China, from January 2014 June 2015 were collected the national centralized reporting system. Spatiotemporal P/S identified cross-validated by calculating local Moran's I, performing hotspot analysis (Getis-Ord Gi*), constructing discrete Poisson model SaTScan. within...