A5073535083- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Sex work and related issues
- HIV Research and Treatment
- interferon and immune responses
- Immune Response and Inflammation
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- COVID-19 diagnosis using AI
- Parvovirus B19 Infection Studies
- Diabetes and associated disorders
- Virus-based gene therapy research
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- Bayesian Methods and Mixture Models
- Infection Control and Ventilation
- Biosensors and Analytical Detection
- Travel-related health issues
- Influenza Virus Research Studies
Hospital Authority
2005-2021
Abstract The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) patients. Serial viral load monitoring generally showed a declining trend. Live virus by culture. Saliva is promising noninvasive specimen for diagnosis, monitoring, and infection control patients with 2019-nCoV infection.
A novel coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—emerged in humans Wuhan, China, December 2019 and has since disseminated globally1,2. As of April 16, 2020, the confirmed case count disease (COVID-19) had surpassed million. Based on full-genome sequence analysis, SARS-CoV-2 shows high homology to SARS-related coronaviruses identified horseshoe bats1,2. Here we show establishment characterization expandable intestinal organoids derived from bats Rhinolophus...
The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, pandemic. There currently lack knowledge about antibody response elicited from SARS-CoV-2 infection. One major immunological question concerns antigenic differences between and SARS-CoV. We address this analyzing plasma patients infected or SARS-CoV immunized mice. Our results show that, although cross-reactivity in binding to spike protein common,...
Coronavirus disease 2019 (COVID-19) has a wide spectrum of severity from mild upper respiratory symptoms to failure. The role neutralizing antibody (NAb) response in progression remains elusive. This study determined the seroprevalence 733 non-COVID-19 individuals April 2018 February 2020 Hong Kong Special Administrative Region and compared responses eight COVID-19 patients admitted intensive care unit (ICU) with those 42 not ICU. We found that NAb against SARS-CoV-2 was detectable any...
Human parvovirus 4 (PARV4), a recently discovered found exclusively in human plasma and liver tissue, was considered phylogenetically distinct from other parvoviruses. Here, we report the discovery of two novel parvoviruses closely related to PARV4, porcine hokovirus (PHoV) bovine (BHoV), samples Hong Kong. Their nearly full-length sequences were also analysed. PARV4-like viruses detected by PCR among 44.4 % (148/333) (including lymph nodes, liver, serum, nasopharyngeal faecal samples), 13...
Individuals with the 2019 coronavirus disease (COVID-19) show varying severity of disease, ranging from asymptomatic to requiring intensive care. Although monoclonal antibodies specific severe acute respiratory syndrome 2 (SARS-CoV-2) have been identified, we still lack an understanding overall landscape B cell receptor (BCR) repertoires in individuals COVID-19. We use high-throughput sequencing bulk and plasma cells collected at multiple time points during infection characterize signatures...
Abstract Severe acute respiratory syndrome (SARS) has caused a major epidemic worldwide. A novel coronavirus is deemed to be the causative agent. Early diagnosis can made with reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal aspirate samples. We compared symptoms 156 SARS-positive and 62 SARS-negative patients in Hong Kong; SARS was confirmed by RT-PCR. The RT-PCR–positive had significantly more shortness breath, lower lymphocyte count, lactate dehydrogenase level;...
Abstract Pre-exposure prophylaxis (PrEP) targeting high-risk men who have sex with (MSM) has been shown to be a cost-effective HIV control measure. However, the approach could challenge in low incidence places proportion of MSM. To examine impact PrEP such setting Asia, we developed an epidemic model and conducted cost-effectiveness analysis using empirical multicentre clinical sequence data from HIV-infected MSM Hong Kong, conjunction behavioural local Without PrEP, (per 100 person-years)...
Since its first appearance in the 1960s, genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case COVID-19 coinfected with HCoV-229E Hong Kong.
Abstract Background: Severe acute respiratory syndrome (SARS) is an emerging infectious disease and diarrhea has been reported in up to 76% of cases. The purpose the present paper was carry out a retrospective study clinical demographic data SARS patients with Princess Margaret Hospital. Methods: From 1 31 March 2003, hospital records from 240 confirmed were studied. Patients watery stool ≥3 times/day for at least 3 consecutive days defined as group. Clinical compared between non‐diarrhea...
Background Undiagnosed infections accounted for the hidden proportion of HIV cases that have escaped from public health surveillance. To assess population risk transmission, we estimated undiagnosed interval each known infection constructing incidence curves. Methods We used modified back-calculation methods to estimate seroconversion year diagnosed patient attending any one 3 specialist clinics in Hong Kong. Three approaches were used, depending on adequacy CD4 data: (A) estimating one's...
Introduction Heterosexual infections have contributed to a high proportion of the HIV burden in Asia and Eastern Europe. Human mobility non-local are important features some cities/countries. An understanding determinants sustained growth heterosexual epidemics would enable potential impacts treatment-based interventions be assessed. Methods We developed compartmental model for transmissions, parameterized by clinical surveillance data (1984–2014) Hong Kong. sequence were included examining...