A5062106013- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- COVID-19 epidemiological studies
- Sex work and related issues
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- COVID-19 Digital Contact Tracing
- Hepatitis B Virus Studies
- Viral Infections and Outbreaks Research
- COVID-19 Pandemic Impacts
- Privacy, Security, and Data Protection
- Reproductive tract infections research
- Substance Abuse Treatment and Outcomes
- Vaccine Coverage and Hesitancy
- Privacy-Preserving Technologies in Data
- Mobile Health and mHealth Applications
- Digital Mental Health Interventions
- Vascular Tumors and Angiosarcomas
- Opioid Use Disorder Treatment
- Survey Methodology and Nonresponse
- AI in Service Interactions
Chinese University of Hong Kong
2015-2024
National Research Council
2024
Hong Kong Jockey Club
2015-2023
Tuen Mun Hospital
2003
Transmission dynamics of SARS-CoV-2 varied by the settings virus exposure. Understanding inter-relationship between exposure setting and transmission networks would provide a basis for informing public health control strategies.Surveillance clinical data from first wave COVID-19 outbreaks in Hong Kong were accessed. Twelve types differentiated - household, neighbourhood, eateries, entertainment, parties, shopping, personalised service, workplace, education, worship, healthcare, transport....
HIV testing is the cornerstone of strategies for achieving fast-track target to end AIDS epidemic by 2030. Self-testing has been proven be an effective health intervention men who have sex with (MSM). While social network-based approaches distributing self-tests are recommended World Health Organization, their implementation consists multiple steps that need properly evaluated.This study aimed assess cascade a self-test approach reaching MSM had never undergone in Hong Kong.This...
Regular HIV and sexually transmitted infection (STI) testing for men who have sex with (MSM) is an important means of prevention, the adoption which remains suboptimal in community.On hypothesis that engagement plays role sexual health monitoring, this study aimed to pilot-test internet-based STI self-sampling enhance MSM regular testing.This 1-year cohort was conducted on HIV-negative aged 18 years or older. A designated website set up enable participants make appointments baseline...
Abstract Pre-exposure prophylaxis (PrEP) targeting high-risk men who have sex with (MSM) has been shown to be a cost-effective HIV control measure. However, the approach could challenge in low incidence places proportion of MSM. To examine impact PrEP such setting Asia, we developed an epidemic model and conducted cost-effectiveness analysis using empirical multicentre clinical sequence data from HIV-infected MSM Hong Kong, conjunction behavioural local Without PrEP, (per 100 person-years)...
Pre-exposure prophylaxis (PrEP) is currently an important tool for HIV prevention, especially in communities with higher risk of infection, notably men who have sex (MSM). To date, PrEP has remained generally unavailable many cities around the world. In planning strategies targeting MSM, community assessment crucial to understand members' responses new intervention.Awareness and acceptance are 2 different but intricately linked contexts PrEP. The aim this study was identify determinants...
Both daily and on-demand regimens have been proven effective for pre-exposure prophylaxis (PrEP) against HIV in men who sex with (MSM). We aimed to compare the two on their coverage of condomless anal intercourse (CLAI) MSM.
Background Exposure risk was shown to have affected individual susceptibility and the epidemic spread of COVID-19. The dynamics by across exposure settings alongside variations following implementation social distancing interventions are understudied. Objective This study aims examine population’s trajectory in different its association with SARS-CoV-2 infection 3 consecutive Omicron waves Hong Kong. Methods From March June 2022, invitation letters were posted 41,132 randomly selected...
Human immunodeficiency virus (HIV) functional cure is a novel biomedical strategy characterized by sustained viral suppression without the need for life-long medications. The attitude of people living with HIV (PLHIV) towards and clinical trials are understudied. We aimed to examine awareness levels anticipation among men who have sex (MSM) HIV, their willingness join as differentiated antiretroviral treatment status.MSM those history were recruited from Hong Kong's specialist clinics....
Background While HIV incidence among men who have sex with (MSM) is increasing in Hong Kong, unprotected apparently remains prevalent those infected but virally non-suppressed. Little known about how sexual behaviours and connections may change MSM along their care continuum. Methods In this retrospective cross-sectional study, HIV-positive attending the largest specialist clinic Kong between October December 2014 were invited to complete a self-administrated structured questionnaire. Their...
Abstract Recombination is an important feature of HIV evolution, occurring both within and between the major branches diversity (subtypes). The Ugandan epidemic primarily composed two subtypes, A1 D, that have been co-circulating for 50 years, frequently recombining in dually infected patients. Here, we investigate frequency recombinants this population location breakpoints along genome. As part PANGEA-HIV consortium, 1,472 consensus genome sequences over 5 kb obtained from 1,857 samples...
Exposure setting is crucial in the formation and propagation of SARS-CoV-2 transmission clusters. In this cohort study, networks 2 waves were differentiated by exposure using territory-wide surveillance data with clinical laboratory records Hong Kong. Characteristically, first wave had resulted from imported cases followed local transmissions, while second was constituted primarily infections. With a 4-fold higher caseload, featured predominance epidemiologically linked, local, older...
Molecular surveillance of infections is essential in monitoring their transmission the population. In this study, newly diagnosed HIV patients' phylogenetic, clinical and behavioural data were integrated, an information diffusion model was incorporated analysing dynamics. A genetic network constructed from sequences, which cascades extracted. From cascades, CRF01_AE had higher values metrics, including scale, speed range, than that B, signifying distinct patterns two circulating subtypes...
The low-threshold methadone maintenance treatment (MMT) programme in Hong Kong has been place for about 40 years. Assessment of the participation pattern users may inform future development to achieve effective harm reduction.Longitudinal clinical data who first registered MMT year 2008 were retrieved after ethical and institutional approval. Participation this cohort was evaluated by examining users' frequency attendance then overall retention rate. A subgroup consistent remained on 2012...
Failure of pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine may occur despite perfect adherence, although this is uncommon. results in breakthrough HIV infection. Delayed seroconversion associated antiretroviral use complicate the picture, causing uncertainties interpreting adherence patterns for establishing true cause PrEP failure.
Human papillomavirus (HPV) vaccination could reduce HPV infection in men who have sex with (MSM), but the published statistics on uptake MSM were scarce globally. This study estimated and profiled service preferences of Chinese Hong Kong. Adult recruited through non-governmental organizations (NGOs) online channels for completing an baseline survey. Factors associated self-reported history identified using multivariable stepwise logistic regression model. Totally 701 completed survey, median...
Renal crisis is a serious complication of systemic sclerosis. Its occurrence prior to the development skin sclerosis exceedingly rare. We report patient who developed acute renal failure during pregnancy. biopsy showed features compatible with scleroderma but typical cutaneous changes were only evident 2 months after episode. The relationship between pregnancy, activity and discussed.
Contact tracing of reported infections could enable close contacts to be identified, tested, and quarantined for controlling further spread. This strategy has been well demonstrated in the surveillance control COVID-19 (coronavirus disease 2019) epidemics. study aims leverage contact data investigate degree spread formation transmission cascades composing multiple clusters.
Digital interventions have been applied for promoting HIV prevention and care among men who sex with (MSM). As user interface (UI) design plays a role in determining usability experience (UX), the intervention outcome could be affected.In this study, we hypothesized that 2 UI styles, namely gamification neumorphism, impact differentially preferred by distinct groups of MSM.A prospective parallel-group open-label randomized controlled trial was conducted Hong Kong. Eligible participants were...