A5005289432- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Blood transfusion and management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hemoglobinopathies and Related Disorders
- Nosocomial Infections in ICU
- Antibiotics Pharmacokinetics and Efficacy
- Methemoglobinemia and Tumor Lysis Syndrome
- Fungal Infections and Studies
- Hidradenitis Suppurativa and Treatments
- Muscle and Compartmental Disorders
Hong Kong Sanatorium and Hospital
2019-2024
Tuen Mun Hospital
2024
Queen Mary Hospital
2011-2023
University of Hong Kong
2013-2022
Hospital Kuala Lumpur
2022
ING Direct
2021
Hong Kong Academy of Medicine
2018
Queen Mary University of London
2000-2011
Background. Experience from treating patients with Spanish influenza and A(H5N1) suggested that convalescent plasma therapy might be beneficial. However, its efficacy in severe pandemic A(H1N1) 2009 virus (H1N1 2009) infection remained unknown. Methods. During the period 1 September through 30 June 2010, we conducted a prospective cohort study by recruiting aged ≥18 years H1N1 requiring intensive care. Patients were offered treatment neutralizing antibody titer of ≥1:160, harvested apheresis...
Aims and objectives. The aim of this study was to investigate the effects music on anxiety patients mechanical ventilation, as assessed by objective parameters a subjective validated scale. Background. Mechanical although sometimes lifesaving, is often associated with levels requiring sedatives, which has inevitable implications costs complications. Design. A randomized controlled trial design. Methods. total 64 subjects randomly assigned undergo either 30 minutes intervention or rest...
Olfactory dysfunction (OD) has been reported in coronavirus disease 2019 (COVID-19). However, there are knowledge gaps about the severity, prevalence, etiology, and duration of OD COVID-19 patients.
Sepsis-induced myocardial dysfunction is a well-recognized condition and confers worse outcomes in septic patients. Echocardiographic assessment by conventional parameters such as left ventricular ejection fraction (LVEF) often affected ongoing changes preload afterload conditions. Novel echocardiographic technologies speckle tracking echocardiography (STE) have evolved for direct of the function. We investigate measurement strain diagnosis sepsis-induced dysfunction. This case-control study...
Background. Healthcare laundry-related infection is rare, and pulmonary zygomycosis due to contaminated hospital linens has never been reported.
AbstractA case-control study was conducted in order to identify the risk factors associated with bloodstream infection caused by Escherichia coli producing extended-spectrum β-lactamase (ESBL) and determine outcomes of infected patients. Risk ESBL production, according univariate analysis, included a history recent hospitalization [odds ratio (OR) 4.3, 95% confidence interval (CI) 2.1-8.9; p < 0.001], severe underlying diseases (OR 15, CI 4.4-51.5; 0.001), prior exposure urinary catheters...
Early antiviral therapy was effective in the treatment of coronavirus disease 2019 (COVID-19). We assessed efficacy and safety combined interferon beta-1b remdesivir hospitalized COVID-19 patients.We conducted a multicentre, prospective open-label, randomized-controlled trial involving high-risk adults for COVID-19. Patients were randomly assigned to 5-day 16 million units daily 200 mg loading on day 1 followed by 100 2 5 (combination group), or only similar regimen (control group) (1:1)....
Abstract Background Globally, mortality rates of patients admitted to the intensive care unit (ICU) have decreased over last two decades. However, evaluations temporal trends in characteristics and outcomes ICU Asia are limited. The objective this study was describe risk adjusted all publicly funded ICUs Hong Kong a 11-year period. secondary validate predictive performance Acute Physiology And Chronic Health Evaluation (APACHE) IV for Kong. Methods This an population-based retrospective...
<b><i>Background:</i></b> oXiris is a blood purification product that has been launched recently in China. In addition to renal function support and fluid management capabilities, it can also adsorb cytokines endotoxins. This may complement standard treatment for septic acute kidney injury (AKI) patients control the amplitude of systemic inflammatory response responsible tissue organ damage. Objectives our study are elucidate characteristics AKI who respond with...
Background Understanding the patient journey is important to optimize care for patients with atopic dermatitis (AD) and overcome challenges in diagnosis management.
With evolving patient characteristics and patterns of ICU utilization, the impact dysnatremias on outcomes healthcare costs in present era have not been well studied. Patients ≥ 18 years admitted to ICUs public hospitals Hong Kong between January 2010 June 2022 had at least one serum sodium measurement obtained within 24 h prior or following admission were stratified into normonatremic (135-145 mmol/L), hyponatremic (< 135 mmol/L) hypernatremic (> 145 groups. A total 162,026 patients...
Allergic diseases are a global problem.Mothers advised to enjoy healthy diet with no restrictions during pregnancy and lactation, as prophylactic dietary restriction is unlikely reduce the development of atopic disease.Breastfeeding recommended for first 6 months newborn's life.Atopic eczema has been shown be significantly reduced in high-risk infants fed hydrolysed formula compared standard cow's milk formula.Complementary food also over 4 if they developmentally ready.Various environmental...
SARS-CoV-2 pandemic has resulted in over 4 million infections yet the role of host immune responses early COVID-19 pathogenesis remains unclear. By evaluating 15 acute and 24 convalescent patients' profile, we report herein infection broad cell reduction including T cells, NK cell, monocytes dendritic cells (DCs). DCs were significantly reduced with functional impairment, cDC/pDC ratios increased among severe patients. Besides lymphocytopenia, although neutralizing antibodies rapidly...
Various strategies of weaning V-A ECMO have been described. PCRTO is a technique which involves serial decremental pump revolutions until retrograde flow from the arterial to venous cannula achieved. It has reported as feasible strategy in pediatric population, but its application adults not widely reported.This was case series including all adult patients who underwent during at tertiary center between January 2019 and July 2021. The primary end point successful support.A total 57 runs 36...
We evaluated the effects of varying blood flow rate during peripheral veno-arterial extracorporeal membrane oxygen (V-A ECMO) on left ventricular function measured by two-dimensional strain.Adult patients who were supported V-A ECMO recruited. Serial hemodynamic and cardiac performance parameters transthoracic echocardiogram within first 48 h after implementation ECMO. Measurements at 100%, 120%, 50% target (TBF) compared.A total 54 included main indications for myocardial infarction [32...
Metformin is a widely used antidiabetic agent that generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to and results in significantly high mortality. A series of 23 MALA cases local major hospital Hong Kong reported this article demonstrate the epidemiological data, risk factors, clinical features as well outcomes for better understanding disease entity. It first case which plasma metformin levels were assessed. show bear no...
The utilization of extracorporeal membrane oxygenation (ECMO) has increased rapidly around the world. Being an overall low-volume high-cost form therapy, effectiveness having care delivered in segregated units across a geographical locality is debatable.All adult cases admitted to public hospitals Hong Kong between 2010 and 2019 were included. "High-volume" centers defined as those with >20 respective calendar year, while "low-volume" ≤20. Clinical outcomes patients who received high-volume...
Severe acute respiratory syndrome (SARS) is highly contagious. Mandatory home confinement of 10 days has generally been recommended to quarantine close contacts SARS cases. We report the epidemiologic linkage within an extended family. The estimated incubation period was beyond in some affected members. One child identified as source transmission another household.