A5001994849- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- COVID-19 Clinical Research Studies
- Aquaculture disease management and microbiota
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Gastric Cancer Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- Hepatitis Viruses Studies and Epidemiology
- Biosensors and Analytical Detection
- Neural dynamics and brain function
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Advanced Text Analysis Techniques
- Neuroscience and Neuropharmacology Research
- Topic Modeling
- Listeria monocytogenes in Food Safety
- Effects and risks of endocrine disrupting chemicals
- Salmonella and Campylobacter epidemiology
Shanghai Customs College
2021-2024
Fudan University
2023-2024
Guangdong Academy of Sciences
2019-2024
Institute of Microbiology
2019-2024
Guangdong Ocean University
2024
Jinan University
2022-2024
First Affiliated Hospital of Jinan University
2022-2023
University of Hong Kong
2021-2022
Queen Mary Hospital
2022
Shanghai Jiao Tong University
2017-2021
By vaccinating SARS-CoV-2 naïve individuals who have already received two doses of COVID-19 vaccines, we aimed to investigate whether a heterologous prime-boost strategy, using vaccines different platforms as the booster dose, can enhance immune response against virus variants. Participants were assigned into four groups, each receiving combination vaccinations: BNT162b2 followed by one dose (B-B-B); Combination (first dose) and CoronaVac (second (B-C-B); (C-C-C); (C-C-B). The neutralizing...
Text classification is a fundamental task in Nature Language Processing(NLP). However, with the challenge of complex semantic information, how to extract useful features becomes critical issue. Different from other traditional methods, we propose new model based on two parallel RNNs architectur e, which captures context information through LSTM and GRU respectively simultaneously. Motivated by siamese network, our proposed architecture generates attention matrix calculating similarity...
Early antiviral therapy was effective in the treatment of coronavirus disease 2019 (COVID-19). We assessed efficacy and safety combined interferon beta-1b remdesivir hospitalized COVID-19 patients.We conducted a multicentre, prospective open-label, randomized-controlled trial involving high-risk adults for COVID-19. Patients were randomly assigned to 5-day 16 million units daily 200 mg loading on day 1 followed by 100 2 5 (combination group), or only similar regimen (control group) (1:1)....
Organophosphorus pesticides (OPs) are an important class of common pesticides. However, due to the abuse organophosphorus pesticides, pesticide residue problems have been highlighted. In this study, colorimetric detection method for OPs residues was established based on broadspectrum aptamer. Through optimization, isocarbophos and omethoate were analyzed verify performance assay. Under optimal conditions, proved effective detecting range 50-1000 ng/mL 100-500 ng/mL. The protective effects...
The emergence of SARS-CoV-2 variants may impact the effectiveness vaccines, while heterologous vaccine strategy is considered to provide better protection. immunogenicity an mRNA-inactivated virus against wild-type (WT) and was evaluated in study. naïve adults (n = 123) were recruited placed following groups: BNT162b2, CoronaVac or BNT162b2-CoronaVac (Combo) Group. Blood samples collected measure neutralization antibodies (NAb) by a live microneutralization assay (vMN) surrogate NAb test....
Vaccinating recovered patients previously infected by COVID-19 with mRNA vaccines to boost their immune response against wild-type viruses (WT), we aimed investigate whether vaccine platform and time of vaccination affect immunogenicity the SARS-CoV-2 WT Delta variant (DV). Convalescent were recruited received one booster dose BNT162b2 (PC-B) or CoronaVac (PC-C) vaccines, while naïve subjects two doses (CN-B) (CN-C) vaccines. The neutralizing antibody in sera DV was determined live virus...
Effective vaccines against SARS-CoV-2 are vital tools for containing the COVID-19 pandemic by increasing population immunity. While currently available can elicit antibody response with high efficacy, associated side effects may cause vaccine hesitancy.
Human noroviruses (HuNoVs) are major foodborne pathogens that cause nonbacterial acute gastroenteritis worldwide. As the tissue-culture system for HuNoVs is not mature enough routine detection of virus, mainly dependent on molecular approaches such as reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time (RT-qPCR). The widely used primers probes RT-qPCR were established in early 2000s. highly variant viruses, viral genome mutations result previously designed...
Human noroviruses (HuNoVs) are among the main pathogens causing acute nonbacterial gastroenteritis. Histo-blood group antigens (HBGAs) widely accepted receptors for HuNoV specific binding. HBGA-like substances in produce also considered as critical ligands capture of HuNoVs. However, composition viral from food substrates remains unknown. In this study, an oligosaccharide (H2N2F2) was captured and isolated romaine lettuce extract by a bacterial surface display system. Using electrospray...
As an important branch of Nature Language Processing (NLP), how to extract useful text information and effective long-range associations has always been a bottleneck for classification. With the great effort deep learning researchers, Convolutional Neural Networks (CNNs) have made remarkable achievements in Computer Vision but still controversial NLP tasks. In this paper, we propose novel CNN named Deep Pyramid Temporal Network (DPTCN) short classification, which is mainly consisting...
Human noroviruses (HuNoVs) are the dominant cause of food-borne outbreaks acute gastroenteritis. However, fundamental researches on HuNoVs, such as identification viral receptors have been limited by currently immature system to culture HuNoVs and lack efficient small animal models. Previously, we demonstrated that recombinant protruding domain (P domain) capsid proteins were successfully anchored surface Escherichia coli BL21 cells after bacteria transformed with a plasmid expressing P...
Vibrio parahaemolyticus is a significant cause of foodborne illness, and its incidence worldwide on the rise. It thus imperative to develop straightforward efficient method for typing strains this pathogen. In study, we conducted pangenome analysis 75 complete genomes V. identified core gene mtlA with highest degree variation, which distinguished 44 outperformed traditional seven-gene-based MLST when combined aer, another high variation. The had higher resolution type close relationship...