A5080568314- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- COVID-19 and Mental Health
- Cancer-related gene regulation
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Autophagy in Disease and Therapy
- Infection Control and Ventilation
- Chemotherapy-induced cardiotoxicity and mitigation
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013-2025
Chongqing Medical University
2015-2025
Kunming Medical University
2019-2021
Weatherford College
2020
Primary Source
2020
Medical Protective
2020
Oklahoma State University
2015-2017
Sun Yat-sen University
2015
Fifth Affiliated Hospital of Sun Yat-sen University
2015
X-Fab (Germany)
2014
Abstract In December 2019, a new coronavirus was found in Wuhan, Hubei Province, China, and spread rapidly throughout the country, attracting global attention. On February 11, World Health Organization (WHO) officially named disease caused by 2019-nCoV 2019 (COVID-19). With increasing number of cases, health care workers (HCWs) from all over China volunteered to work Province. Because strong infectivity COVID-19, HCWs need wear personal protective equipment (PPE), such as N95 masks, latex...
Background: Due to its high infectivity and concealment, the coronavirus disease 2019 (COVID-19) outbreak that occurred in Wuhan attracted global attention. A special nursing group of transdisciplinary nurses (TNs) who had not worked respiratory medicine, infection departments, or emergency intensive medicine but accounted for a large proportion all also drew our Few studies have examined this TNs. Therefore, study collected experiences views TNs at forefront COVID-19 investigate their...
Abstract The spread of coronavirus disease 2019 (COVID-19) around the world has put a heavy burden on human society and is also great challenge facing medical staff. This study aimed to assess difficulties faced by health care personnel (HCP) in using personal protective equipment (PPE) clinical practice during COVID-19 outbreak Wuhan, China. One hundred twenty staff from First Affiliated Hospital Chongqing Medical University presented Wuhan provide assistance, whom 20 HCP volunteered...
Objectives: This study aims to explore the roles of thirteen m6A RNA methylation regulators in clear cell renal carcinoma (ccRCC), and identify a risk signature prognostic values ccRCC. Material methods: sequence data ccRCC was obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed stratified by different clinicopathological characteristics were unveiled using "limma" package R version 3.6.0. Cox regression LASSO analyses conducted powerful independent factors...
Abstract A malformed tumour vascular network provokes the nutrient‐deprived microenvironment (TME), which conversely activates endothelial cell (EC) functions and stimulates neovascularization. Emerging evidence suggests that flexible metabolic adaptability of cells helps to establish a symbiosis among various subpopulations in fluctuating TME. In this study, authors propose novel link between bladder cancer (BCa) ECs nutrient‐scarce TME, BCa‐secreted glutamine‐fructose‐6‐phosphate...
To investigate current status of diagnosis and treatment bladder cancer in China.A database was generated by Chinese Bladder Cancer Consortium (CBCC). From January 2007 to December 2012, 14,260 cases from 44 CBCC centers were included. Data diagnosis, pathology collected.The average age 63.5 year-old most patients male (84.3%). The common histologic types urothelial carcinoma (91.4%), adenocarcinoma (1.8%), squamous (1.9%). According 1973 2004 WHO grading system, 42.0%, 41.0%, 17.0% grade 1,...
This study aimed to assess the long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger (mRNA) regulatory network in clear cell renal carcinoma (ccRCC) by gene expression analyses.LncRNA, miRNA, and mRNA profiles ccRCC were obtained from The Cancer Genome Atlas. Differentially expressed lncRNAs, mRNAs (cut-off: |log 2 [fold change, FC])| > 2.0 adjusted P < 0.01) miRNAs (|log 2FC| 1.5 unveiled using R. Cox regression analysis was performed identify prognostic factors of related overall survival...
Renal cell carcinoma (RCC) is one of the most common aggressive malignant tumors in urogenital system, and clear renal (ccRCC) subtype carcinoma. Immune related long non-coding RNAs (IRlncRs) plentiful immune cells microenvironment (IME) are potential evaluating prognosis assessing effects immunotherapy. A completed meaningful IRlncRs analysis based on abundant ccRCC gene samples from The Cancer Genome Atlas (TCGA) will provide insight this field.Based TCGA dataset, we integrated expression...
790 Background: Fexagratinib (former AZD4547), a selective and potent oral inhibitor of FGFR1-3, has shown promising efficacy safety in phase I trials among solid tumor pts with FGFR1-3 alterations, including mUC. This study (NCT05086666) aimed to assess Fexa previously treated Chinese mUC FGFR alterations. Methods: Pts harboring FGFR3 alterations (including activating mutations or fusion detected via NGS panel) who failed at least 1 prior therapy were platinum- ineligible, enrolled....
Purpose This study aimed to determine the prognostic value of preoperative Neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic renal cell carcinoma (mRCC) undergoing cytoreductive nephrectomy (CN).
Metabolic reprogramming and epigenetic alternations are implicated in tumor progression metastasis, but the metabolic mechanisms underlying lymphatic distant metastasis of bladder cancer (BCa) remain poorly understood. In this study, we provide first evidence that glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), crucial rate-limiting switch hexosamine biosynthesis pathway (HBP), is considerably upregulated nutrient-scarce microenvironment causes a high O-GlcNAcylation signal...
The present study investigated the effect of transplanting endothelial progenitor cells (EPCs) transfected with vascular growth factor gene (VEGF165) into corpora cavernosa rats diabetic erectile dysfunction (ED).A rat model ED was constructed via intraperitoneal injection streptozotocin.After streptozotocin treatment, pre-treated EPCs from each three groups were transplanted their cavernosa.Our results, following intracavernosal pressure (ICP) monitoring, showed that ICP increased...
The aim of this study was to investigate the regulatory network lncRNAs as competing endogenous RNAs (ceRNA) in bladder urothelial carcinoma (BUC) based on gene expression data derived from Cancer Genome Atlas (TCGA).RNA sequence profiles and clinical information 414 BUC tissues 19 non-tumor adjacent were downloaded TCGA. Differentially expressed samples identified using R package "edgeR". Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis performed "clusterProfiler" package. Gene...
Background: Papillary renal cell carcinoma (pRCC) was the 2nd most common subtype, accounting for approximately 15% incidence of (RCC). Immune related long non-coding RNAs (IR-lncRs) plentiful in immune cells and microenvironment (IME) are potential evaluating prognosis assessing effects immunotherapy. A completed meaningful IR-lncRs analysis based on abundant pRCC gene samples from The Cancer Genome Atlas (TCGA) will provide insight this field. Results: 17 were selected by Pearson...
The aim of this study was to develop and validate a reliable nomogram estimate overall survival in bladder cancer.Patients diagnosed with cancer identified the Surveillance, Epidemiology, End Results database were randomly divided into training validation cohorts. powerful prognostic variables examined using Cox regression analyses. A developed on factors.The results suggested that age, sex, race, grade, histologic type, primary site, pathological stage, surgical treatment, number tumors,...
This study aims to develop and validate a CT-based radiomics nomogram integrated with clinic-radiological factors for preoperatively differentiating high-grade from low-grade clear cell renal carcinomas (CCRCCs).370 patients complete clinical, pathological, CT image data were enrolled in this retrospective study, randomly divided into training testing sets 7:3 ratio. Radiomics features extracted nephrographic phase (NP) contrast-enhanced images, then model was constructed by the selected...
There are no reliable criteria to assess risk of progression non‑muscle invasive bladder cancer muscle cancer. The aim the present study was identify potential markers based on gene expression profiling improve predictive power disease and prognosis in patients with In study, we screened seventy‑three differentially expressed genes by analyzing samples or without progression. Forty‑seven prognosis‑related were screened, 13 which identified build a progression‑associated signature using LASSO...
Renal cell carcinoma (RCC) is one of the most common malignant tumors urinary system, which clear renal (ccRCC) accounts for subtypes. The increasing discoveries abundant autophagy-related long non-coding RNAs (ARLNRs) lead to a resurgent interest in evaluating their potential on prognosis prediction. Based large number ccRCC gene samples from TCGA and clinics, ARLNRs analysis will provide novel perspective into this field.We calculated autophagy scores each sample according expression...
Abstract Obesity is strongly associated with insulin resistance (IR), along mitochondrial dysfunction to metabolically active tissues and increased production of reactive O 2 species (ROS). Foods rich in antioxidants such as wheat germ (WG), protect from damage due ROS modulate some negative effects obesity. This study examined the WG supplementation on markers IR, substrate metabolism innate antioxidant two (i.e. liver heart) C57BL/6 mice fed a high-fat–high-sucrose (HFS) diet. Male mice,...
Panax notoginseng saponins (PNS), which have an antioxidant property, are a widely used traditional Chinese medicine. In this study we investigated whether PNS can improve erectile function in rats with dysfunction and the underlying mechanism by using rat diabetic model. The were randomly divided into four groups: three PNS-treated groups (50, 100 150 mg/kg) one saline-treated control group. Four weeks post treatment, electrostimulation was applied to cavernous nerve intracavernous pressure...
Rapamycin, an immunosuppressant, is widely used in patients with kidney transplant. However, the therapeutic effects of rapamycin remain controversial. Additionally, previous studies have revealed deleterious predominantly when administered for ≥24 h. Few studies, however, focused on short term only during initial reperfusion phase. As such, we designed this study to explore potential and mechanisms under a specific regimen which mixed perfusate phase (within 24 h). Interestingly, found that...