A5025699862- Gut microbiota and health
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Microbial Metabolites in Food Biotechnology
- Nutrition, Genetics, and Disease
- Inflammatory Bowel Disease
- Nutrition and Health in Aging
- Phytoestrogen effects and research
- IL-33, ST2, and ILC Pathways
- RNA regulation and disease
- Metabolomics and Mass Spectrometry Studies
- Microscopic Colitis
- Mangiferin and Mango Extracts
- Clinical Nutrition and Gastroenterology
- Phytochemicals and Antioxidant Activities
- Food Science and Nutritional Studies
- Trace Elements in Health
- GABA and Rice Research
- Immune Cell Function and Interaction
- Digestive system and related health
- Liver physiology and pathology
- Nuts composition and effects
- Atherosclerosis and Cardiovascular Diseases
Stanford University
2022-2024
Oklahoma State University
2015-2024
Cincinnati Children's Hospital Medical Center
2020-2021
Oklahoma State University Oklahoma City
2019-2021
University of Toronto
1989
McMaster University Medical Centre
1989
Sunnybrook Health Science Centre
1989
Abstract Obesity is strongly associated with insulin resistance (IR), along mitochondrial dysfunction to metabolically active tissues and increased production of reactive O 2 species (ROS). Foods rich in antioxidants such as wheat germ (WG), protect from damage due ROS modulate some negative effects obesity. This study examined the WG supplementation on markers IR, substrate metabolism innate antioxidant two (i.e. liver heart) C57BL/6 mice fed a high-fat–high-sucrose (HFS) diet. Male mice,...
Evidence of dried plum's benefits on bone continues to emerge. This study investigated the contribution fruit's polyphenol (PP) and carbohydrate (CHO) components a model postmenopausal osteoporosis explore their prebiotic activity. Osteopenic ovariectomized mice were fed diets supplemented with plum, crude extract polyphenolic compounds, or PP CHO fraction extract. The effects treatments phenotype assessed at 5 10 weeks as well activity different plum. Both fractions contributed suppressing...
Ulcerative colitis (UC) is associated with epithelial metabolic derangements which exacerbate gut inflammation. Patient-derived organoids recapitulate complexities of the parent tissue in health and disease; however, whether colon (colonoids) model impairments pediatric UC epithelium unclear. This study determined functional differences epithelia using colonoids from patients.
Brain zinc dysregulation is linked to many neurological disorders. However, the mechanisms regulating brain homeostasis are poorly understood. We performed secondary analyses of MRI GWAS and exome sequencing data from adults in UK Biobank. Coding ZIP12 polymorphisms transporter (SLC39A12) were associated with altered susceptibility weighted (swMRI). Conditional joint association revealed independent signals linkage disequilibrium 2 missense polymorphisms, rs10764176 rs72778328, reduced...
Ten adult patients on continuous ambulatory peritoneal dialysis (CAPD) received one dose of trimethoprim-320 mg (TMP) and sulfamethoxazole 1600 (SMX) orally (p.o.), intravenously (i.v.), intraperitoneally (i.p.) three separate occasions to characterize the pharmacokinetics both drugs. Concentrations TMP SMX were measured in serum dialysate by HPLC 48 h. Half-life, total body clearance (TBC), (PCl) determined. The mean half-life was 28 h, while for it 12.5 Relative i.v. dose, bioavailability...
Physiologic, molecular, and genetic findings all point to impaired intestinal epithelial function as a key element in the multifactorial pathogenesis of ulcerative colitis (UC). The lack epithelial-directed therapies is conspicuous weakness our UC therapeutic armamentarium. However, critical barrier new drug discovery preclinical human models UC. Patient tissue-derived colon organoids (colonoids) are primary stem cell-derived vitro structures capable self-organization self-renewal that hold...
Postprandial fluxes in oxidative stress, inflammation, glucose, and lipids, particularly after a high-fat meal (HFM), have been implicated the development of cardiovascular disease (CVD). The aim this study is to determine whether acute freeze-dried mango consumption modulates postprandial response an HFM. We hypothesized that addition mango, which rich source many bioactive components, HFM would lower triglycerides, increase antioxidant enzymes, compared standard alone.In randomized...
We aimed to determine whether a targeted gene expression panel could predict clinical outcomes in paediatric ulcerative colitis [UC] and investigated putative pathogenic roles of predictive genes.
Wheat consumption has declined amid growing concerns about gluten-sensitivity. To determine if genetic manipulation of wheat contributes to systemic and localized gut inflammation, we compared the effects modern variety Gallagher a blend two heirloom varieties, Turkey Kharkof, on measures structural characteristics, barrier integrity under normal Western diet (WD) conditions in C57BL/6 mice. Indicators including lymphocyte infiltration cytokine expression, were largely unaffected by WD or...
Fermentable non‐digestible carbohydrates and fiber from plant food sources are suggested to prevent high fat (HF) diet‐induced gut microbial dysbiosis other obesity‐related outcomes. Various parts of mango have been studied for their anti‐obesogenic, immunomodulatory gastro‐protective properties. This study investigated the effects 12‐week freeze‐dried pulp supplementation on microbiota fermentation products, its impact body composition, glucose homeostasis inflammatory markers in C57BL/6...
Obesity is strongly associated with insulin resistance (IR), along mitochondrial dysfunction in metabolically active tissues and increased production of reactive oxygen species (ROS). Foods rich antioxidants such as wheat germ (WG), are thought to protect from damage due ROS modulate some negative effects obesity‐induced IR. This study examined the WG supplementation on resistance, substrate metabolism innate antioxidant markers two (i.e. liver heart) C57BL/6 mice fed a high fat (HF) diet....
Watermelon is a delicious and healthy fruit that contains low calories rich in carotenoids, vitamin A, C, citrulline, other bioactive compounds. The health benefits of watermelon diabetes are poorly understood. In the current study, we sought to determine effects juice on gut microbiome profile blood glucose management type 1 2 diabetic mice. Six-week-old male C57BL/6 J wild (WT), db/db (db/db), streptozocin (STZ)-induced (STZ) mice were fed chow diet given 50% or 100% tape water during...
Commensal gut bacteria, including Lactobacillus, can produce metabolites that stimulate the release of antimicrobial peptides (AMPs) via signal transducer and activator transcription (STAT)3 pathway prevent obesity-associated leaky chronic inflammation. We have previously reported wheat germ (WG) selectively increased cecal Lactobacillus in obese mice.This study investigated effects WG on STAT3 activation AMPs (Reg3γ Reg3β) as well potential to inhibit nuclear Nf-κB-activation immune cell...
Obesity and its co‐morbidities have been associated with mitochondrial oxidative stress leading to impaired substrate oxidation. This study aimed at investigating the potential ameliorating effects of freeze‐dried mango pulp supplementation on body composition capacity in liver heart mice fed a high fat‐diet. Six‐week old male C57BL/6 were randomly assigned 1 3 dietary treatment groups: control, fat (HF=60% fat) HF + 10% (w/w) for 12 weeks. Mango had modest effect preventing increase weight...