A5057832019- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Safe Handling of Antineoplastic Drugs
- Anesthesia and Sedative Agents
- Analytical Methods in Pharmaceuticals
- Political Conflict and Governance
- Pharmacogenetics and Drug Metabolism
- Neutropenia and Cancer Infections
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS drug development and treatment
- Pharmaceutical Practices and Patient Outcomes
- Health, Medicine and Society
- Healthcare Systems and Practices
- Antibiotic Resistance in Bacteria
- Health Systems, Economic Evaluations, Quality of Life
- Intravenous Infusion Technology and Safety
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Epilepsy research and treatment
- Bacterial Identification and Susceptibility Testing
- Venous Thromboembolism Diagnosis and Management
- Health Sciences Research and Education
- Pharmacy and Medical Practices
- Treatment of Major Depression
Beatson West of Scotland Cancer Centre
2024
Sunnybrook Health Science Centre
2013-2023
Health Sciences Centre
2012-2023
University of Toronto
2011-2023
United Arab Emirates University
2019-2023
Children's Hospital of Eastern Ontario
2023
Newcastle University
2022
AstraZeneca (Japan)
2017
University of Canterbury
2006-2014
3M (United States)
2009-2014
Abstract BACKGROUND: Treatment of febrile neutropenia (FN) is costly, because it typically involves hospitalization. As cancer rates continue to increase, the number patients suffering from FN will also making important quantify costs treating this condition accurately and comprehensively. METHODS: A consecutive sample admitted an inpatient hematology/oncology ward at a tertiary care hospital for treatment chemotherapy‐induced was enrolled in study. Patients were followed prospectively...
The stability of diluted solutions sodium hypochlorite was studied. Sodium 1% were (1:8, 1:12, and 1:20) stored at room temperature in a window exposed to sunlight amber-glass, two-liter bottles that two-thirds full. Samples taken 25 times throughout six-month study period; opened only on sampling days. An iodometric titration used determine the percent available chlorine each sample. Least-squares regression analyses yielded lines with negative slopes for dilution (-7.7 X 10(-6), -8.1 -1.5...
In mid-2000, a broiler chicken company in Alabama experienced high early mortality rates chicks from two different hatcheries. Five isolates of Pseudomonas aeruginosa, obtained these contaminated hatcheries and resulting with omphalitis, were selected to determine virulence the bacteria. One-day-old specific-pathogen-free white leghorn placed into positive pressure isolation units (10 per unit); feed water provided ad libitum. The five P. aeruginosa (1 × 101 or 1 102 colony-forming...
OBJECTIVE: To compare the rate and extent of systemic salicylate absorption following single multiple applications two topically applied analgesics, one containing methyl other trolamine salicylate. DESIGN: Two-period, two-treatment, randomized, crossover, multiple-dose study in healthy men women volunteers. PARTICIPANTS: Six six volunteers, 21–14 years age. INTERVENTIONS: Subjects 5 g an ointment 12.5% twice daily for 4 days (8 doses) or a cream 10% doses, to 10-cm 2 area on thigh....
The aim of this study is to provide clearer guidelines for rational, safe, and practical dietary restriction use with monoamine oxidase inhibitors. Tyramine levels were assayed in over 100 the controversial foods that have been associated hypertensive reactions or reported contain high tyramine. Only a very limited number appear require absolute restriction. These include all aged cheeses, concentrated yeast extracts (e.g., Marmite), sauerkraut, broad bean pods. Alcoholic beverages,...
Traditional monoamine oxidase inhibitors (MAOIs) remain an important class of drugs for a variety psychiatric conditions, including depressive illnesses, anxiety, and eating disorders.It was the objective this study to refine MAOI diet by determining tyramine content untested "controversial" foods that continue appear on diet-restricted food lists. A secondary evaluate effect freshness some foods. Fifty-one samples were evaluated liquid chromatography. Food included selection sausages,...
The oral anticoagulant warfarin is clinically administered as a racemic mixture of two enantiomers, (R) and (S). Many relevant drug interactions with have been attributed to the specific metabolic inhibition elimination more pharmacologically active (S)‐enantiomer. To investigate reports that acetaminophen can potentiate effect warfarin, 20 healthy male volunteers were each given single mg doses on three separate occasions: (1) alone, (2) after 1 day (4 g/d), (3) 2 weeks g/d). urinary...
Eight normal subjects were given 250 mg intravenous phenytoin alone and with 3-day regimens of oral Cimetidine, 400 at bedtime, 1200 a day, 2400 day in randomized crossover fashion. Plasma samples for urinary concentrations 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) measured by HPLC. All Cimetidine decreased clearance, there was no difference between the 400-mg bedtime dose 1200-mg regimens. There was, however, 2400-mg linear correlation steady state plasma decrease clearance. Urinary...
Aminopyridine has been shown to improve spasticity and ambulatory speed in patients with multiple sclerosis (MS), spinal cord injuries, neuromuscular diseases.1–4 Four-aminopyridine (4-AP) selectively blocks fast, voltage-gated potassium channels excitable tissues increases the influx of calcium at nerve terminals, thereby enhancing transmission.1 It is this mechanism action, however, that predispose adverse events, specifically seizures.1,2,5 ### Case reports. In Ontario, Canada, from...
Variability in neonatal vancomycin pharmacokinetics and the lack of consensus for optimal trough concentrations intensive care units pose challenges to dosing neonates. Our objective was determine neonates evaluate regimens identify whether practical initial recommendations that targeted most commonly used could be determined. Fifty who received with at least one set steady-state levels were evaluated retrospectively. Mean pharmacokinetic values determined using first-order equations, Monte...
BackgroundFebrile neutropenia is a serious toxicity of cancer chemotherapy that usually treated in hospital. We assessed the cost-effectiveness filgrastim and pegfilgrastim as primary prophylaxis against febrile diffuse large B-cell lymphoma (DLBCL) patients undergoing chemotherapy.
In the post-World War II era, international human rights standards have evolved, establishing in law a set of basic designed to guarantee an acceptable level personal dignity for all people. A long list is presented Universal Declaration Human Rights 1 and later covenants conventions. Increasingly, degree which these are realized considered important standard regime's performance.
Antimicrobial resistance (AMR) constitutes an international public health threat widely believed to result from excessive antimicrobial use (AMU). Numerous authorities have recommended stewardship programs (ASPs) curb the selection of AMR, but there is a lack data confirming this benefit.A controlled interrupted time-series study spanning 14 years was performed assess impact comprehensive hospital-based ASP that included pharmacist-led audit and feedback on institutional AMR. Patient-level...
Abstract Background Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed randomized controlled trial (RCT) to ascertain the effect composite endpoint death or persistent organ dysfunction at 28 days patients with Methods LOVIT (Lessening Organ VITamin C) multicenter, parallel-group, blinded (participants,...