A5065143293- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Plasmonic and Surface Plasmon Research
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Physiological and biochemical adaptations
- Thyroid Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Intestinal and Peritoneal Adhesions
- Urticaria and Related Conditions
- Ovarian cancer diagnosis and treatment
- Circular RNAs in diseases
- Genetics and Physical Performance
- Aerosol Filtration and Electrostatic Precipitation
Shaoxing People's Hospital
2024-2025
Dalian Medical University
2020-2024
Shandong University
2015-2024
Zhejiang Ocean University
2024
Second Affiliated Hospital of Dalian Medical University
2020-2024
China Medical University
2020-2024
Binzhou University
2024
Binzhou Medical University
2024
Fujian Agriculture and Forestry University
2024
Liaoning Cancer Hospital & Institute
2020-2024
Background: Spine surgery causes severe pain and can be associated with significant opioid utilization; however, the evidence for opioid-sparing analgesic techniques such as erector spinae plane (ESP) block from controlled studies is limited. We aimed to investigate effects of ESP in lumbar laminoplasty. Methods: In this prospective, double-blind, single-center trial, 62 consecutive elective laminoplasty patients were randomized into either a control group (Group G, N=32) or treatment E,...
Cervical squamous cell carcinoma (CESC) is a human papillomavirus-driven tumor that the underlying molecular mechanisms are unclear. This study aimed to elucidate key candidate genes and potential mechanism in CESC by bioinformatics analysis. A total of 132 common differentially expressed (DEGs) were identified based on three expression profile data sets. multivariate Cox proportional regression model was used develop four-gene prognostic signature. Mechanistically, correlationship between...
A high-resolution and wide-range pressure sensor based on π phase-shifted fiber Bragg grating (π-FBG) encapsulated with metal thin-walled cylinder is reported. The has been tested a wavelength-sweeping distributed feedback laser, photodetector H 13 C 14 N gas cell. To perceive temperature synchronously, pair of π-FBGs are glued the outer wall along circumferential direction different angles. interference effectively corrected by high-precision calibration algorithm. reported sensitivity 4.42...
Abstract A novel, highly selective biomarker is urgently needed to predict and monitor triple-negative breast cancer (TNBC) because targeting molecules are not currently available. Although associated with various malignant tumors, the role of toll-like receptor 5 (TLR5) in TNBC remains uncertain. We aimed define effects TLR5 determine whether it could serve as a prognostic monitoring indicator for TNBC. established cell line 4T1 low expression (GFP tag; − 4T1) normal + using...
Abstract Background Tissue factor pathway inhibitor 2 (TFPI2) participates in carcinogenesis of various tumors, and is associated with poor survival breast cancer patients. However, the effect underlying mechanism TFPI2 on progression remains to be investigated. Methods The expression level tissues cell lines was examined via qRT-PCR (quantitative real-time polymerase chain reaction) immunohistochemistry. CCK8 (Cell Counting Kit-8), colony formation, wound healing or transwell assays were...
Higher oxidant stress capacity could promote invasion and metastasis. A previous study showed hepatocellular carcinoma (HCC) expressed more Nrf2 than para-carcinoma tissue. The chemotherapeutics such as epirubicin (EPI) increase expression, while Camptothecin (CPT) inhibit tumor growth by down-regulating the key molecule of antioxidant signal—Nrf2. role in metastasis was still unclear. In this study, we use EPI CPT to determine Huh7 cells, H22 mouse models. expression ROS level were found...
In recent years, frequent acute temperature changes have posed a serious threat to fish. This study utilized RNA-Seq technology analyze the transcriptional dynamics in muscle tissues of Acrossocheilus wenchowensis under various conditions (16◦C, 20◦C, 24◦C, 28◦C and 32◦C). Through DEGs analysis, STEM clustering WGCNA, we identified 11509 DEGs, gene set (profiles 19) that significantly up-regulated with increasing two WGCNA modules (black turquoise) were correlated high low stresses,...
Heterotopic pancreas, an uncommon condition in children, can present with diagnostic and treatment challenges. This study aimed to evaluate the clinical features options for this disorder pediatric patients.
Replication factor C3 (RFC3) is an oncogene that can potentially predict prognosis in a variety of human cancers. RFC3 expression ovarian carcinoma has not yet been determined. In this study, we evaluated the messenger RNA (mRNA) and protein levels normal tissues using reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, Western blots (WB). Results showed higher mRNA were detected by RT-PCR WB. High was defined as positive staining >70 % each tumor cell. 28.1,...
Abstract Triple‐negative breast cancer (TNBC) is a highly aggressive tumour that lacks marker for targeted diagnosis. Recently, it was reported toll‐like receptor 5 (TLR5) associated with some kind of tumours, especially in TNBC, but whether could be used as non‐invasive monitoring target not fully understood. Here, we established TLR5 − 4T1 cell line lentivirus‐shRNA‐TLR5 knock‐down transfection (with tag GFP, green fluorescent protein, 4T1) and control + negative lentivirus transfection....
Atherosclerotic coronary artery disease (CAD) is one of the most prevalent diseases worldwide. Atherosclerosis was considered to be single important contributor CAD. In this study, a distinct serum protein expression pattern in CAD patients demonstrated by proteomic analysis with two-dimensional gel electrophoresis coupled mass spectrometry. particular, CDK9 found highly elevated serum, monocytes and plaque samples patients. Furthermore, there high infiltration CD14+ monocytes/macrophages...
In recent years, frequent acute temperature changes have posed a serious threat to the physiology and survival of fish. This study utilized RNA-Seq technology analyze transcriptional dynamics in muscle tissues Acrossocheilus wenchowensis under various conditions (16◦C, 20◦C, 24◦C, 28◦C 32◦C). Through comprehensive analysis, we identified 11509 differentially expressed genes (DEGs), gene set (profiles 19) that was significantly up-regulated with increasing temperature, two weighted...
Background: We aimed to evaluate the effect of different capnoperitoneum pressures on stress responses in pediatric laparoscopic inguinal hernia repair. Methods: In this prospective randomized controlled study, 68 children with indirect who underwent high ligation sac were randomly divided into 3 groups: high-pressure group (12 mm Hg, HP group, n = 26); low-pressure (8 LP 20); open operation (OP 22). Heart rate (HR), blood pressure, and end-tidal CO2 (PetCO2) recorded, as well levels...
Abstract EGFR fusions are rare genomic events in non-small cell lung cancer (NSCLC), and a total of nine types have been previously reported adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3, EGFR-ZCCHC6. fusion mutations combined with amplification even rarer NSCLC. The EGFR–intergenic region (IGR) mutation is unreported, thus, there no studies targeting this together adenocarcinoma. Our brief study provides clinical evidence...
A real-time seawater temperature measurement system based on a wavelength swept distributed feedback (DFB) laser is developed. The <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\pi $ </tex-math></inline-formula> phase-shifted fiber Bragg grating ( -FBG) with narrow bandwidth of 12 pm used as the sensing probe. by linearly and periodically modulating driving current sawtooth wave signal. absorption line...
Recently, emerging evidence strongly suggested that the activation of interleukin-27 Receptor α (IL-27Rα) could modulate different inflammatory diseases. However, whether IL-27Rα affects allotransplantation rejection is not fully understood. Here, we investigated role on allorejection both in vivo and vitro. The skin mice models were established, dynamic IL-27Rα/IL-27 expression was detected, IL-27Rα+ spleen cells adoptive transfer performed. STAT1/3/5 phosphorylation, proliferation...
Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic. Age is an independent factor in death from the disease, and predictive models to stratify patients according their mortality risk are needed.To compare laboratory parameters of younger (≤70) elderly (>70) groups, develop prediction for two groups age stratification.A retrospective, single-center observational study.This study included 437 hospitalized with laboratory-confirmed COVID-19 Tongji Hospital Wuhan, China,...
Lung cancer, especially non-small cell lung cancer (NSCLC), is the most common malignant tumor associated with poor prognosis. Angiogenesis plays a vital role in NSCLC, and could be used staging therapy evaluation. CD93 (C1q receptor) reportedly key regulator of angiogenesis. In present study, efficacy specificity 125I-labeled CD93-specific monoclonal antibody (125I-anti-CD93 mAb) detecting NSCLC xenografts were analyzed, association between expression 125I-anti-CD93 mAb uptake by tumors was...