Lei Geng

ORCID: 0000-0003-0216-5602
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About
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Research Areas
  • Gastrointestinal disorders and treatments
  • Hernia repair and management
  • Appendicitis Diagnosis and Management
  • Hydrogen's biological and therapeutic effects
  • Anesthesia and Neurotoxicity Research
  • Biochemical effects in animals
  • Intestinal Malrotation and Obstruction Disorders
  • Orthopaedic implants and arthroplasty
  • Orthopedic Infections and Treatments
  • Testicular diseases and treatments
  • Pediatric Hepatobiliary Diseases and Treatments
  • Tissue Engineering and Regenerative Medicine
  • Mycobacterium research and diagnosis
  • Shoulder Injury and Treatment
  • Esophageal and GI Pathology
  • Restraint-Related Deaths
  • Tryptophan and brain disorders
  • Diagnosis and treatment of tuberculosis
  • Intestinal and Peritoneal Adhesions
  • Flavonoids in Medical Research
  • Phagocytosis and Immune Regulation
  • Reconstructive Surgery and Microvascular Techniques
  • Garlic and Onion Studies
  • Cancer-related cognitive impairment studies
  • Vascular Malformations and Hemangiomas

Binzhou Medical University
2019-2024

Binzhou University
2019-2024

Affiliated Hospital of Southwest Medical University
2024

Zhejiang University
2011-2023

First Affiliated Hospital Zhejiang University
2011-2022

Chinese PLA General Hospital
2016-2022

State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2022

Henan Psychiatric Hospital
2016

Chinese People's Liberation Army
2016

Xian Yang Central Hospital
2016

Background Intestinal malrotation is a rare condition, and its delayed diagnosis can lead to fatal consequences. This study aimed investigate the identification treatment of in children. Methods Clinical data, imaging, operative findings, early postoperative outcomes 75 children with were retrospectively analyzed. Results The mean age was 6.18 ± 4.93 days 51.26 70.13 months neonatal group (56 patients) non-neonatal (19 patients), respectively. Sixty-seven patients under 1 year at time...

10.3389/fped.2024.1390856 article EN cc-by Frontiers in Pediatrics 2024-05-13

Heterotopic pancreas, an uncommon condition in children, can present with diagnostic and treatment challenges. This study aimed to evaluate the clinical features options for this disorder pediatric patients.

10.1007/s00383-024-05722-z article EN cc-by Pediatric Surgery International 2024-05-29

The study was to analyze the clinical manifestation variety and management choices of symptomatic Meckel's diverticulum in children. From July 2008 October 2018, 28 cases with a complications were admitted our hospital. data included age, gender, symptoms signs, investigations, intraoperative pathological findings, outcome. ratio males females 2.5 : 1. diagnoses made by 99mTc-pertechnetate scan (in 5 cases) exploratory laparotomy 2 cases). initial diagnosis other includes intussusception 4...

10.1155/2021/6640660 article EN cc-by Gastroenterology Research and Practice 2021-02-08

AimTo investigate the effects of hydrogen-rich saline (HRS) on intestinal epithelial tight junction (TJ) barrier in rats with ischemia–reperfusion injury (IIRI).Materials and methodsThirty-two healthy male Sprague–Dawley (SD) were randomly divided into four groups (n = 8 each): Sham group, I/R HRS group 4-PBA group. After 45 min ischemia 6 h reperfusion, sacrificed to collect serum ileum for detection. Hematoxylin eosin (H&E) staining was used observe morphology small intestine. The...

10.1016/j.jpedsurg.2020.01.061 article EN cc-by-nc-nd Journal of Pediatric Surgery 2020-02-22

Multiple high-powered magnetic Buckyball ingestions may lead to a high risk of severe complications. Great concerns have been raised by public health workers, and it remains challenging for clinicians solve this troublesome problem. We report large case series children with ingestion from six tertiary medical centers. The clinical data, including demographics, history, diagnosis tools, management options, intraoperative or endoscopic findings, outcomes, were retrospectively analyzed....

10.3389/fpubh.2022.892756 article EN cc-by Frontiers in Public Health 2022-06-15

The diagnosis of a periprosthetic joint infection (PJI) is always difficult point in research on the surgery joints. current diagnostic criteria include comprehensive analysis multiple tests; however, there are no effective visual examinations yet that can differentiate between aseptic loosening and PJI.This case report describes four patients with symptomatic total hip arthroplasty (THA), two cases infection. Although were correctly diagnosed by tissue culture, preoperative tests...

10.3389/fmed.2022.1014463 article EN cc-by Frontiers in Medicine 2022-11-24

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal dystrophies characterized by progressive photoreceptor apoptosis.Reactive oxygen species (ROS) have been recognized as critical initiators the apoptosis in RP.Photoreceptor survival RP mutants will not only require inhibition effectors apoptotic machinery, but also elimination initiating upstream signals, such ROS.These cytotoxic ROS should be neutralized antioxidant defense system, otherwise they would interact with...

10.12659/msm.897107 article EN Medical Science Monitor 2016-03-08

Giant greater omental cysts with associated massive hemorrhage are rare. We encountered a 16-month-old boy four-day history of acute abdominal pain, distension, and paleness. Physical examination revealed blood pressure 74/27 mmHg. No well-defined masses were observed on palpation. The hemoglobin level admission was 24 g/L. After initial resuscitation transfusion, computed tomography (CT) scan performed, revealing giant cystic mass an intracystic hemorrhage. diagnosis confirmed via...

10.3389/fmed.2023.1255545 article EN cc-by Frontiers in Medicine 2023-09-28

This study aimed to explore the characteristics of pediatric upper gastrointestinal (UGI) perforations, focusing on their diagnosis and management.Between January 2013 December 2021, 30 children with confirmed UGI perforations were enrolled, clinical data analyzed. Two groups compared according management options, including open surgical repair (OSR) laparoscopic/gastroscopic (LR).A total patients a median age 36.0 months (1 day-17 years) included in study. There 19 11 LR OSR groups,...

10.3389/fped.2023.1261336 article EN cc-by Frontiers in Pediatrics 2023-10-11

Abstract Background The management strategy of Bacille Calmette-Guérin (BCG) vaccine-induced regional suppurative lymphadenitis in children is still controversial and more clinical studies are needed. We therefore present a surgical case series to explore the role for this dilemma. Methods From January 2013 June 2020, data from 65 patients diagnosed with BCG were retrospectively reviewed. Clinical characteristics, ultrasonographic findings, procedures, perioperative management, outcome...

10.1186/s12879-021-06531-8 article EN cc-by BMC Infectious Diseases 2021-08-11

To evaluate the safety and reliability of a novel technique single-port laparoscopic-assisted percutaneous precise closure inguinal hernia sac in children.From September 2016 through 2019, children with hernia(s) treated extraperitoneal using guide wire were enrolled this study. Operative time, surgical complications, recurrence rate, cosmetic results collected.A total 917 cases collected. Among them, there 886 (96.61%) boys 31 girls. Their mean age was 5.2 ± 3.7 years. There 693 (75.57%)...

10.1155/2021/6679519 article EN cc-by Gastroenterology Research and Practice 2021-06-25

Anal canal duplication (ACD) is a rare entity of gastrointestinal that may be asymptomatic or present complications, such as abscess, fistulae, malignant changes. The diagnosis and rational management ACD still need to clarified.

10.3389/fped.2024.1452116 article EN cc-by Frontiers in Pediatrics 2024-09-05

Developing functional ductal organoids (FDOs) is essential for liver regenerative medicine. We aimed to construct FDOs with biliary tree networks in rat decellularized scaffolds (DLSs) primary cholangiocytes isolated from mouse bile ducts. The developed were dynamically characterized by assays and metabolomics bioprocess clarification. reconstructed DLSs retaining native structure bioactive factors expressing enriched biomarkers. Morphological assessment showed that tree-like structures...

10.2139/ssrn.4331338 preprint EN 2023-01-01

Iliopsoas abscess with septicemia in the pediatric population is rare. Early diagnosis and effective management of this emergent disorder remain challenging for clinicians.A 14-year-old girl presented right lateral posterior hip pain fever 7 days before admission. Blood culture was positive Staphylococcus aureus. Enhanced magnetic resonance imaging revealed abscesses located iliopsoas muscle on surface deep to fascia sacroiliac joint that were 6.8 cm × 6.2 5.7 3.7 3.5 2.1 cm, respectively. A...

10.3389/fsurg.2022.871292 article EN cc-by Frontiers in Surgery 2022-06-27

Congenital short bowel syndrome (SBS) associated with malrotation, gut volvulus and jejuno-ileal atresia is a very rare condition. It severe challenge for surgeons to preserve residual ischemic segment in the management of syndrome,especially neonates.We report newborn baby malrotation atresia, congenital SBS jejunal volvulus. Hematemesis abdominal distention were noted. At laparotomy, jenunal was confirmed. The total length small 63 cm proximal measuring 38 cm, including 18 necrotic below...

10.12998/wjcc.v7.i20.3353 article EN World Journal of Clinical Cases 2019-10-25

目的 探讨旋股外侧动脉降支-膝上外侧动脉穿支逆行股前外侧皮瓣修复膝周、小腿中上段皮肤软组织缺损的手术方法及临床应用效果。 方法 回顾性分析2010年1月—2015年12月解放军第105医院显微骨科收治的21例膝周、小腿中上段皮肤软组织缺损患者的临床资料。其中男17例,女4例;年龄26~58岁,平均39岁;皮肤、软组织缺损部位为膝周、小腿中上段前外后侧;皮肤、软组织缺损大小12 cm×8 cm~20 cm×12...

10.3760/cma.j.issn.2095-7041.2017.06.014 article ZH-CN Chin J Anat Clin 2017-12-06

Objective To investigate the effects of Baicalin on intestinal mucosal injury in rats with partial common bile duct ligation (PCBDL). Methods Forty male Wistar were randomly divided into 4 groups equally: sham operation, PCBDL, PCBDL1 and PCBDL2.Rats PCBDL2 subjected to ligation.Baicalin [80 mg/(kg·d)]was fed group (for 2 weeks) group(for 3 weeks), while for other groups, 9 g/L saline same volume was fed.Ileum mucosa prepared microscopic examination.The observed scored.The level NF-κB...

10.3760/cma.j.issn.2095-428x.2014.07.009 article EN Zhonghua shiyong erke linchuang zazhi 2014-04-05

Objective To investigate the expression of inositol requiting enzyme1α (IRE1α) and tumor necrosis factor receptor-associated 2(TRAF2) its significance through establishing models intestinal ischemia reperfusion injury (IIRI) in rats. Methods According to random number table, 50 male SD rats were randomly divided into 2 groups: sham operation group (n=10) (I/R) (n=40). Sham animals underwent laparotomy.I/R subjected occlusion superior mesenteric artery for 30 min; then blood flow was...

10.3760/cma.j.issn.2095-428x.2016.07.009 article EN Zhonghua shiyong erke linchuang zazhi 2016-04-05

Nocardia infection is rare but potentially fatal. Therapy of remains difficult. Linezolid, a novel oxazolidinone antibiotic, has proven to be effective, clinical data are limited. Here we describe case 45-year-old man with pulmonary N. farcinica following liver transplantation. The initial therapy was trimethoprim-sulfamethoxazole, which showed no effect. According susceptibility test, linezolid administered clearly improving the patient's condition. treatment stopped for anemia as drug...

10.1590/s1413-86702011000500014 article EN cc-by-nc-nd The Brazilian Journal of Infectious Diseases 2011-10-01
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