A5090713347- Congenital gastrointestinal and neural anomalies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Intestinal Malrotation and Obstruction Disorders
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Urological Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Digestive system and related health
- Colorectal Cancer Treatments and Studies
- Congenital Diaphragmatic Hernia Studies
- Healthcare and Venom Research
- Pediatric Urology and Nephrology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Ureteral procedures and complications
- Gout, Hyperuricemia, Uric Acid
- Bone and Joint Diseases
- Neuroblastoma Research and Treatments
- Medical Research and Treatments
- Spondyloarthritis Studies and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Qilu Hospital of Shandong University
2014-2025
Yancheng First People's Hospital
2024
Nanfang Hospital
2021
Southern Medical University
2017-2021
Tongji University
2009-2020
Shanghai Pulmonary Hospital
2008-2020
Saint Petersburg State Pediatric Medical University
2018
Shandong University
2005-2017
Weihai Municipal Hospital
2017
Harbin Institute of Technology
2017
Abstract Background Understanding how enteric neural crest cells (ENCCs) differentiate into neurons is crucial for neurogenesis therapy and gastrointestinal disease research. This study explores magnesium ions regulate the glycolytic pathway to enhance ENCCs differentiation neurons. Materials methods We used polymerase chain reaction, western blot, immunofluorescence, multielectrode array techniques assess ions' impact on differentiation. Non-targeted metabolomic sequencing, cellular...
Epithelial-to-mesenchymal transition (EMT) has profound impacts on cancer progression and also drug resistance, including epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Nowadays, there is still no predictive biomarker identified for the use of EGFR-TKIs in non-small cell lung (NSCLC) patients with wild-type EGFR. To clarify role EMT phenotype as a marker EGFR-TKI, we performed retrospective study 202 stage IV or recurrent NSCLC receiving gefitinib erlotinib therapy...
Background Intestinal malrotation is a rare condition, and its delayed diagnosis can lead to fatal consequences. This study aimed investigate the identification treatment of in children. Methods Clinical data, imaging, operative findings, early postoperative outcomes 75 children with were retrospectively analyzed. Results The mean age was 6.18 ± 4.93 days 51.26 70.13 months neonatal group (56 patients) non-neonatal (19 patients), respectively. Sixty-seven patients under 1 year at time...
Abstract Background Both clinical and preclinical studies revealed that regular intake of green tea reduced the prevalence depressive symptoms, as well produced antidepressant-like effects in rodents. Evidence proposed disturbed reward learning has been associated with development anhedonia, a core symptom depression. However, relationship between is poorly investigated. Our goal was to test whether chronic treatment healthy subjects affects process subsequently regulates symptoms. Methods...
Background The RhoA/Rho kinase pathway may participate in the pathogenesis of hypoxia and monocrotaline induced pulmonary hypertension. This study tested whether is involved high flow hypertension rats. Methods Male Wistar rats (4 weeks) were randomly divided into 4 shunt groups, treated groups control groups. Shunt underwent left common carotid artery/external jugular vein operation. Control sham Treated received fasudil treatment others same dose saline. At weeks 1, 2, 8 study, right...
To compare efficacy and safety profile of vinorelbine, ifosfamide cisplatin (NIP) with etoposide (EP) in the treatment advanced combined small cell lung cancer (c-SCLC).From January 2006 to December 2010, 176 patients c-SCLC were enrolled. The primary endpoint was overall survival (OS) secondary endpoints progression free (PFS), response rate (RR) toxicity.Overall RR 30.0% NIP 38.5% EP group; there no significant difference (P=0.236). PFS group little longer than that group, 6.5 months for...
// Tao Jiang 1,* , Aiwu Li Chunxia Su 1 Xuefei 2 Chao Zhao Shengxiang Ren Caicun Zhou and Jun Zhang 3 Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School Medicine, Shanghai, P.R. China Lung Immunology, Internal Division Hematology, Oncology Blood & Marrow Transplantation, Holden Comprehensive Center, Iowa, Carver College IA, USA * These authors contributed equally to this paper Correspondence to: Zhou, email: Ren, Keywords :...
To investigate the safety and effectiveness of laparoscopic management choledochal cysts compared with open approach, even in early childhood. Methods: We conducted a retrospective study 206 patients between June 2003 May 2015. Of these, 104 underwent cyst excision hepaticojejunostomy (open operation [OP]) 102 received (laparoscopic [LP]). The who approach were further divided by age 3 years. patients' perioperative follow-up conditions 2 approaches groups. Results: All cured no incidence...
Importance Reperfusion therapy is the most effective treatment for acute ischemic stroke but remains underused in China. Objective To evaluate effect of a problem-oriented, culturally adapted, targeted quality improvement intervention on reperfusion patients with Design, Setting, and Participants In this stepped-wedge cluster randomized clinical trial, from 16 secondary 33 tertiary hospitals China within 6 hours symptom onset were consecutively recruited between July 1, 2018, June 30, 2020....
Previous studies have revealed that ankylosing spondylitis (AS), as the progenitor of axial spondyloarthritis (AxSpA), has been characterized by insidiously progressive nature sacroiliitis and spondylitis. Dual-energy computed tomography (DECT) recently used to analyse deposition monosodium urate (MSU) crystals with higher sensitivity specificity. However, it remains unclear whether existence MSU crystal detected DECT at sacroiliac joint in patients AxSpA also is associated existing...
Neuroblastoma (NB) is the most common extracranial tumor in children. YTHDC1, a member of RNA methylation modification binding proteins, plays critical roles occurrence and metastasis. However, it unclear whether YTHDC1 gene polymorphisms are related to NB susceptibility. Herein, we aimed evaluate association between (rs2293596 T>C, rs2293595 rs3813832 T>C) susceptibility by logistic regression models. In this eight-center case-control study, 898 patients with 1734 healthy controls were...
One stage transanal Soave pull-through procedure (TSPP) is a recent popular operation in the treatment of Hirschsprung's disease (HD). With no visible scar and short hospital stay, it well accepted by surgeons mothers. In conventional procedure, long rectal muscular cuff left for anocolic anastomosis might increase incidence postoperative enterocolitis constipation. This study presents modified (MTSPP) which includes an oblique mucosectomy with split cuff.A review two groups HD patients was...
Hirschsprung's disease (HSCR) is a common newborn defect. This study aimed to identify critical genes involved in the development of HSCR. Differently expressed (DEGs) public data set GSE98502 were analyzed using paired t-test. Gene Ontology (GO) and Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses performed Database for Annotation, Visualization Integrated Discovery (DAVID) 6.8. Besides, Coexpression network long noncoding RNAs (lncRNAs)-mRNAs (message RNA) constructed...