A5101684787- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Tracheal and airway disorders
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Congenital Heart Disease Studies
- Trauma Management and Diagnosis
- Aortic Disease and Treatment Approaches
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Vascular Anomalies and Treatments
- Congenital Diaphragmatic Hernia Studies
- Foreign Body Medical Cases
- Renal and Vascular Pathologies
- Respiratory Support and Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Radiopharmaceutical Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Transplantation: Methods and Outcomes
Taizhou People's Hospital
2020-2025
Nanjing Medical University
2022-2025
Nantong University
2020-2025
Jilin University
2025
University of Alabama at Birmingham
2008-2024
First Affiliated Hospital of Zhengzhou University
2017-2024
Central South University
2012-2024
Southern Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Second Affiliated Hospital of Jilin University
2024
The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both. However, we cannot predict onset of testicular advance. Using single-cell RNA sequencing (scRNA-seq) from Gene Expression Omnibus (GEO) database, conducted cell-cell communication network human testis between older and young group, indicating Leydig cellsâ potential role...
Objective To explore the risk factors for cardiotoxicity in patients with gastrointestinal (GI) tumors treated fluorouracil drugs. Methods This study included GI who received at our hospital between January 2018 and April 2022. The demographic clinical characteristics were collected. associated of explored using multivariable logistic regression. Results A total 300 finally divided into ( n = 81) non-cardiotoxicity groups 219). occurrence fluorouracil-induced was higher hypertension,...
It is anticipated that bioactive fragments of the extracellular matrix (matrikines) can influence development and progression chronic diseases. The enzyme leukotriene A4 hydrolase (LTA4H) mediates opposing proinflammatory anti-inflammatory activities, through generation B4 (LTB4) degradation proneutrophilic matrikine Pro-Gly-Pro (PGP), respectively. We show abrogation LTB4 signaling ameliorated inflammation airway hyperresponsiveness (AHR) in a murine asthma model, yet global loss LTA4H...
Pulmonary drug delivery presents a unique opportunity to target lower airway inflammation, which is often characterized by the massive recruitment of neutrophils from blood. However, specific therapies are lacking modulation neutrophil function, and difficult challenges must be overcome achieve therapeutic efficacy against pulmonary notably hydrophobicity, mucociliary macrophage-dependent clearance, high extracellular protease burden. Here, we present multistage, aerodynamically favorable...
Traditional Chinese medicine (TCM) has been used to prevent, treat and diagnose diseases for 5,000 years under the guidance of TCM theories. fingerprinting technology, as model quality control TCM, promotes application all over world. But how realize fast matching, retrieval, recognition, identification function fingerprint data is an urgent problem in study fingerprint. The establishment database provides a powerful platform popularization aim this paper therefore summarize research process...
Acute respiratory distress syndrome (ARDS) is characterized by unrelenting polymorphonuclear neutrophil (PMN) inflammation and vascular permeability. The matrikine proline-glycine-proline (PGP) acetylated PGP (Ac-PGP) have been shown to induce PMN endothelial permeability in vitro vivo. In this study, we investigated the presence role of airway peptides acute lung injury (ALI)/ARDS. Pseudomonas aeruginosa-derived lipopolysaccharide (LPS) was instilled intratracheally mice ALI, increased...
Soluble sugars, malic acid, and ascorbic acid in 17 apple cultivars (Malusdomestica Borkh.) three wild forms (M. pumila 'Saiwaihong', M. prunifolia (Willd.) Borkh. micromalus Makino) from major cultivation regions China were quantified using gas chromatography equipped with flame ionization detector (GC-FID). Fructose was the most abundant sugar, followed by sucrose, glucose, sorbitol. Wild apples contain more sorbitol less sucrose significantly acidic than cultivated fruits. The total sugar...
The angiopoietin 1 (Ang1)/angiopoietin receptor (Tie2) signaling pathway may have a notable role in the pathogenesis of inflammatory diseases. abnormal expression and Tie2 has also been reported various malignant tumors, including papillary thyroid carcinoma (PTC). However, mechanism Ang1/Tie2 progression PTC remains unclear. Therefore, aims present study were to clarify this. Significantly high levels Ang1 observed tissues cell lines. Furthermore, MTT wound-healing assays revealed that...
Abstract Phenolic compounds in apples 17 cultivars ( Malus domestica Borkh.) and 3 wild forms sp.) were analyzed to study the impact of genetic background, growth site, fruit bagging. The altitude was studied nine by analyzing fruits collected from orchards at three altitudes. Procyanidin B2 (71–628 μg/g fresh weight), −)-epicatechin (35–357 μg/g), chlorogenic acid (28–563 μg/g) always most abundant phenolic apple samples studied, except for cultivar ‘Qinguan’, which had a very low content...
Background Chronic kidney disease (CDK) is a worldwide health problem, but there currently no effective treatment that can completely cure this disease. Recently, studies with mesenchymal stem cells (MSCs) on treating various renal diseases have shown breakthroughs. This study to observe the homing features of MSCs transplanted via artery and effects fibrosis in reversible unilateral ureteral obstruction (R-UUO) model. Methods Thirty-six Balb/c mice were divided into UUO group, UUO-MSC sham...
The objective of this study is to estimate the probability cause-specific mortality using a competing-risks nomogram and recursive partitioning analysis in large population-based cohort patients with esophageal neuroendocrine carcinoma. surveillance, epidemiology end results database was used identify 162 diagnosed carcinoma from 1998 2014. We estimated cumulative incidence function for mortality. A constructed by proportional subdistribution hazard model, validated bootstrap...
Background Traditional metal stents are not always suitable for patients with circuitous malignant esophageal stricture. Purpose We aimed to report the safety and effectiveness of stent insertion using self-expanding segmental radioactive in palliation Material Methods conducted a retrospective analysis 22 consecutive who underwent from November 2016 March 2019. Technical success, dysphagia score, complications were analyzed. Kaplan–Meier was used analyze survival time. Results The stenting...
Third-generation tyrosine kinase inhibitors (TKIs), such as osimertinib, almonertinib and furmonertinib, overcome the mechanisms of resistance to first-generation (such gefitinib, erlotinib icotinib) by incorporating an acrylamide group that alkylates Cys797 EGFR T790M. However, drug is inevitable, even for third-generation TKIs. Screening drug-resistant mutations repeat biopsy gene sequencing necessary after TKI treatment. Among various TKI-resistant mutations, secondary mutation L718...
Both receptor-binding domain in spike protein (S-RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human neuropilin-1 (NRP1) are important the virus entry, their concomitant inhibition may become a potential strategy against SARS-CoV-2 infection. Herein, five novel dual S-RBD/NRP1-targeting peptides with nanomolar binding affinities were identified by structure-based virtual screening. Particularly, RN-4 was found to be most promising peptide targeting S-RBD (Kd = 7.4...
The conventional esophageal stent is not flexible enough for refractory or circuitous stenosis. After placement, the bending stress may stimulate tissue proliferation in both ends of stent, causing restenosis, severe bleeding fistula. A fully covered self-expandable segmental was designed and used to overcome such shortcoming. This study aims safety effectiveness metallic stents placement palliation dysphasia patients with stenosis.Retrospective hospital records a consecutive series 24 who...
Non-typeable Haemophilus influenzae (NTHi) is a common inhabitant of the human nasopharynx and upper airways that can cause opportunistic infections airway mucosa including bronchopulmonary in patients with chronic obstructive pulmonary disease (COPD). It clear contribute significantly to inflammatory exacerbations COPD; however, there remains much be learned regarding specific host microbial determinants persistence and/or clearance this context.In study, we used recently described ferret...
Available vaccine-based immunity may at high risk of being evaded due to substantial mutations in the variant Omicron. The main protease (Mpro) SARS-CoV-2 and human neuropilin-1 (NRP1), two less mutable proteins, have been reported be crucial for replication entry into host cells, respectively. Their dual blockade avoid vaccine failure caused by continuous genome exert synergistic antiviral efficacy. Herein, four cyclic peptides non-covalently targeting both Mpro NRP1 were identified using...
To describe our experience of reducing anastomotic leakage, a problem that has not been properly solved.