A5072204600- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Supramolecular Self-Assembly in Materials
University of Oregon
2024
The Wallace H. Coulter Department of Biomedical Engineering
2019-2021
Georgia Institute of Technology
2019-2021
U.S. National Science Foundation
2019
Pulmonary drug delivery presents a unique opportunity to target lower airway inflammation, which is often characterized by the massive recruitment of neutrophils from blood. However, specific therapies are lacking modulation neutrophil function, and difficult challenges must be overcome achieve therapeutic efficacy against pulmonary notably hydrophobicity, mucociliary macrophage-dependent clearance, high extracellular protease burden. Here, we present multistage, aerodynamically favorable...
Injury and disease in the central nervous system (CNS) can result a dysregulated inflammatory environment that inhibits repair of functional tissue. Biomaterials present promising approach to tackle this complex inhibitory modulate mechanisms involved neuroinflammation halt progression secondary injury promote In review, we will cover recent advances biomaterial strategies, including nanoparticles, hydrogels, implantable scaffolds, neural probe coatings, have been used innate immune response...
Abstract The human bone marrow (hBM) is a complex organ critical for hematopoietic and immune homeostasis, where many cancers metastasize. Yet, understanding the fundamental biology of hBM in health diseases remain difficult due to complexity studying or manipulating BM humans. Accurate vitro models microenvironment are further our niche advancing new clinical interventions. Although, culture that recapitulate some key components have been reported, there no examples fully human, , organoid...