A5088471119- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetics and Plant Breeding
- Bioinformatics and Genomic Networks
- Plant biochemistry and biosynthesis
- Lipid metabolism and biosynthesis
- Nitrogen and Sulfur Effects on Brassica
- Gene expression and cancer classification
- Nicotinic Acetylcholine Receptors Study
- Smoking Behavior and Cessation
- Wheat and Barley Genetics and Pathology
- Pancreatic and Hepatic Oncology Research
- Birth, Development, and Health
- Rice Cultivation and Yield Improvement
- Genomics and Rare Diseases
- Statistical Methods and Inference
- COVID-19 and healthcare impacts
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Emergency and Acute Care Studies
- Obesity and Health Practices
- GABA and Rice Research
- Genomic variations and chromosomal abnormalities
- Eating Disorders and Behaviors
University of Florida
2002-2025
Florida College
2020-2024
University of Florida Health
2022-2023
UF Health Cancer Center
2022-2023
University of Alabama at Birmingham
2009-2022
Washington Center
2019-2022
American Association of Colleges of Pharmacy
2020
University of Arkansas for Medical Sciences
2017-2019
Triangle
2019
Indianapolis Zoo
2019
We tested six single nucleotide polymorphisms (SNPs) in the α4 subunit gene (CHRNA4) and four SNPs β2 (CHRNB2) of nicotinic acetylcholine receptors (nAChRs) for association with nicotine dependence (ND), which was assessed by smoking quantity (SQ), heaviness index (HSI) Fagerström test ND (FTND) 2037 subjects from 602 nuclear families either European-American (EA) or African-American (AA) ancestry. Analysis within CHRNA4 demonstrated that EA sample rs2273504 rs1044396 are significantly...
Alzheimer’s disease (AD) affects more than 10% of the population ≥65 y age, but underlying biological risks most AD cases are unclear. We show anti-poly-glycine-arginine (a-polyGR) positive aggregates frequently accumulate in sporadic autopsy brains (45/80 cases). hypothesize that these caused by one or polyGR-encoding repeat expansion mutations. developed a CRISPR/deactivated-Cas9 enrichment strategy to identify candidate GR-encoding mutations directly from genomic DNA isolated a-polyGR(+)...
Identification of multifactor gene-gene (G×G) and gene-environment (G×E) interactions underlying complex traits poses one the great challenges to today's genetic study. Development generalized dimensionality reduction (GMDR) method provides a practicable solution problems in detection interactions. To exploit opportunities brought by availability diverse data, it is high demand develop corresponding GMDR software that can handle breadth phenotypes, such as continuous, count, dichotomous,...
Interleukin-1 (IL-1) plays a key role in carcinogenesis and several IL-1-targeted therapeutics are under investigation for the treatment of pancreatic ductal adenocarcinoma (PDAC). We sought to broaden our understanding how family IL-1 ligands receptors impact tumor immune landscape patient survival PDAC. Gene expression data DNA methylation IL1A, IL1B, IL1RN, IL1R1, IL1R2, IL1RAP was attained from The Cancer Genome Atlas (TCGA) database cross validated using National Center Biotechnology...
Abstract Several previous genome‐wide and targeted association studies revealed that variants in the CHRNA5 – CHRNA3 CHRNB4 ( CHRNA5/A3/B4 ) gene cluster on chromosome 15 encode α5, α3, β4 subunits of nicotinic acetylcholine receptors (nAChRs) are associated with nicotine dependence (ND) European Americans (EAs) or others origin. Considering distinct linkage disequilibrium patterns other ethnic populations such as African (AAs), it would be interesting to determine whether associations exist...
Detection of interacting risk factors for complex traits is challenging. The choice an appropriate method, sample size, and allocation cases controls are serious concerns. To provide empirical guidelines planning such studies data analyses, we investigated the performance multifactor dimensionality reduction (MDR) generalized MDR (GMDR) methods under various experimental scenarios. We developed mathematical expectation accuracy used it as indicator parameter to perform a gene-gene...
Matrix metalloprotease-9 (MMP-9) plays a role in progression of cystic fibrosis, and doxycycline can reduce MMP-9 vitro . Here, we explore the effect during fibrosis exacerbation treatment on related readouts clinical end-points. This randomised, double-blind, placebo-controlled study enrolled hospitalised patients with undergoing exacerbation. In total, 20 participants were given 19 placebo over an 8-day period hospitalisation. Biospecimens collected at beginning end period. Primary...
Brassica napus is an important oilseed crop. Dissection of the genetic architecture underlying oil-related biological processes will greatly facilitates improvement rapeseed. The differential gene expression during pod development offers a snapshot on genes responsible for oil accumulation in. To identify candidate in linkage peaks reported previously, we used RNA sequencing (RNA-Seq) technology to analyze transcriptomes German cultivar Sollux and Chinese inbred line Gaoyou.The samples were...
Background It is well known that white matter injuries observed at birth are associated with adverse neurodevelopmental outcomes later in life. Whether developmental variations healthy newborns also changes neurodevelopment remains to be established. Purpose To evaluate whether of microstructures identified by MRI correlate full-term infants. Materials and Methods In this prospective study, pregnant women were recruited their underwent a brain including diffusion tensor imaging approximately...
The genetic mapping of polymorphic markers in a cross between two inbred plant lines has proven to be powerful method for detecting quantitative trait loci (QTL) underlying complex traits. However, existing methods QTL were developed disomic inheritance both marker and diploid population. To map influencing traits expressed the endosperm, triploid embryo-nourishing tissue resulting from double fertilization, models require modification consider trisomic endosperm generation difference...
With the development of next-generation sequencing technology, there is a great demand for powerful statistical methods to detect rare variants (minor allele frequencies (MAFs)<1%) associated with diseases. Testing each variant site individually known be underpowered, and therefore many have been proposed test association group phenotypes, by pooling signals in chromosomal region. However, this strategy inevitably leads inclusion large proportion neutral variants, which may compromise power...
<b><i>Objective:</i></b> The existing methods for identifying multiple rare variants underlying complex diseases in family samples are underpowered. Therefore, we aim to develop a new set-based method an association study of dichotomous traits samples. <b><i>Methods:</i></b> We introduce framework testing the genetic with based on generalized linear mixed model. Our proposed is kernel machine regression and can be viewed as extension sequence...
Abstract Xieyou9308 is a certified super hybrid rice cultivar with high grain yield. To investigate its underlying genetic basis of yield potential, recombinant inbred line (RIL) population derived from the cross between maintainer XieqingzaoB (XQZB) and restorer Zhonghui9308 (ZH9308) was constructed for identification quantitative trait SNPs (QTSs) associated two important agronomic traits, plant height (PH) heading date (HD). By re-sequencing 138 lines (RILs), total ~0.7 million were...
Abstract Because of uncertainty about linkage phases founders, mapping in nonmodel, outcrossing systems using molecular markers presents one the major statistical challenges genetic research. In this article, we devise a method for QTL affecting complex trait by incorporating all possible QTL-marker within framework. The advantage model is simultaneous estimation and location effect parameters. These estimates are obtained through maximum-likelihood methods implemented with EM algorithm....
Cottonseed is one of the most important raw materials for plant protein, oil and alternative biofuel diesel engines. Understanding complex genetic basis cottonseed traits requisite achieving efficient improvement traits. However, it not yet clear about their architecture in genomic level. GWAS has been an effective way to explore quantitative human many crops. This study aims dissect mechanism seven by a improvement. A genome-wide association (GWAS) based on full gene model with effects as...
Acute respiratory distress syndrome (ARDS) is characterized by unrelenting polymorphonuclear neutrophil (PMN) inflammation and vascular permeability. The matrikine proline-glycine-proline (PGP) acetylated PGP (Ac-PGP) have been shown to induce PMN endothelial permeability in vitro vivo. In this study, we investigated the presence role of airway peptides acute lung injury (ALI)/ARDS. Pseudomonas aeruginosa-derived lipopolysaccharide (LPS) was instilled intratracheally mice ALI, increased...
Pancreatic ductal adenocarcinoma (PDAC) is currently the third-leading cause of cancer-related death in United States. African Americans (AAs) with PDAC have worse survival comparison to other racial groups. The COVID-19 pandemic caused significant stress healthcare system. We aim evaluate pandemic's impact on already known disparities newly diagnosed patients Florida.