A5006293505- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Pregnancy and preeclampsia studies
- Child Nutrition and Feeding Issues
- Nutritional Studies and Diet
- Diet and metabolism studies
- Infant Health and Development
- Infant Development and Preterm Care
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Language Development and Disorders
- Per- and polyfluoroalkyl substances research
- Phytoestrogen effects and research
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Obesity and Health Practices
- Neonatal and fetal brain pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Epigenetics and DNA Methylation
- Physical Activity and Health
- Reproductive System and Pregnancy
- Ovarian function and disorders
Arkansas Children's Nutrition Center
2016-2025
University of Arkansas for Medical Sciences
2016-2025
Arkansas Children's Hospital
2014-2024
Pediatrics and Genetics
2009-2020
University of Applied Management Studies
2019
Agricultural Research Service
2016
University of Tennessee Health Science Center
2016
University of South Carolina
2016
Arkansas Department of Health
2016
University of Arkansas at Fayetteville
2009
Purpose To compare brain gray and white matter development in healthy normal weight obese children. Methods Twenty‐four 8‐ to 10‐year‐old children whose body mass index was either <75 th percentile (normal weight) or >95 (obese) completed an MRI examination which included T1‐weighted three‐dimensional structural imaging diffusion tensor (DTI). Voxel‐based morphometry used the regional between children, tract‐based spatial statistics water parameters groups. Results Compared with had...
Neonatal diet has a large influence on child health and might modulate changes in fecal microbiota metabolites. The aim is to investigate metabolites at different ages infants who were breastfed (BF), received dairy-based milk formula (MF), or soy-based (SF). Fecal samples collected 3 (n = 16, 12, 14, respectively), 6 20, 19, 15, 9 11, 12 mo respectively) for BF, MF, SF infants. Infants that until switched considered as no longer breastfeeding mo. Microbiota data obtained using 16S ribosomal...
Human milk oligosaccharides (HMOs) are bioactive molecules playing a critical role in infant health. We aimed to quantify the composition of HMOs women with normal weight (18.5–24.9 kg/m2), overweight (25.0–29.9 or obesity (30.0–60.0 kg/m2) and determine effect HMO intake on growth. (HM) samples collected at 2 months (2 M; n = 194) postpartum were analyzed for concentrations via high-performance liquid chromatography. Infant HM intake, anthropometrics body assessed M 6 postpartum. Linear...
Human milk contains all of the essential nutrients required by infant within a complex matrix that enhances bioavailability many those nutrients. In addition, human is source bioactive components, living cells and microbes facilitate transition to life outside womb. Our ability fully appreciate importance this relies on recognition short- long-term health benefits and, as highlighted in previous sections supplement, its ecology (i.e., interactions among lactating parent breastfed well...
Although soy formula has been reported to support normal development, concerns exist regarding potential adverse developmental effects of phytochemicals associated with protein. This study characterized status (mental, motor, and language) breastfed (BF), milk-based formula-fed (MF), or protein-based (SF) infants during the first year life.Healthy (N = 391) were assessed longitudinally at ages 3, 6, 9, 12 months. Development was evaluated by using Bayley Scales Infant Preschool Language...
Obesity is associated with low-grade chronic inflammation, which contributes to cellular dysfunction promoting metabolic disease. during pregnancy leads a proinflammatory milieu in the placenta; however, underlying causes for obesity-induced placental inflammation remain unclear. Here, we examine mechanisms by saturated fatty acids and inflammatory cytokines induce trophoblasts. We conducted global transcriptomic profiling BeWo cells following palmitate and/or TNFα treatment gene/protein...
Objective The longitudinal trajectories of body composition children born to mothers with normal weight, overweight, and obesity have not been evaluated using precise methods. This study investigated the relationship between maternal prepregnancy BMI offspring during first 6 years life. Methods Healthy infants ( N = 325) were assessed longitudinally (at ages 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, years) dual‐energy X‐ray absorptiometry. Mixed‐effects regression for repeated measures was used model...
Abstract The contributions of maternal diet and obesity in shaping offspring microbiome remain unclear. Here we employed a mouse model diet-induced via high-fat feeding (HFD, 45% fat calories) for 12 wk prior to conception on gut microbial ecology. Male female were provided access control or HFD from weaning until 17 age. Maternal HFD-associated programming was sexually dimorphic, with male dams showing hyper-responsive weight gain postnatal HFD. Likewise, analysis cecal contents showed...
It is hypothesized that obesity adversely affects the ovarian environment, which can disrupt oocyte maturation and embryonic development. This study aimed to compare gene expression profiles follicular fluid (FF) content from overweight/obese (OW) women normal-weight (NW) who were undergoing fertility treatments. Using single-cell transcriptomic analyses, we investigated using RNA sequencing. Eleven OW 13 NW treatments enrolled. Oocyte messenger as well serum FF hormone lipid levels...
Maternal obesity is an important determinant of offspring risk, which may be mediated via changes in the infant microbiome.We examined faecal microbiome, short-chain fatty acids (SCFA), and maternal human milk oligosaccharides (HMO) mothers with overweight/obese body mass index (BMI) (OW) compared normal weight (NW) (Clinicaltrials.gov NCT01131117).Infant stool samples at 1, 6, 12 months were analysed by 16S rRNA sequencing. (BODPOD) (quantitative nuclear magnetic resonance [QMR]) adiposity...
To study potential effects of maternal body composition on central nervous system (CNS) development newborn infants.Diffusion tensor imaging (DTI) was used to evaluate brain white matter in 2-week-old, full-term, appropriate for gestational age (AGA) infants from uncomplicated pregnancies normal-weight (BMI < 25 at conception) or obese ( BMI = 30 and otherwise healthy mothers. Tract-based spatial statistics (TBSS) analyses were voxel-wise group comparison fractional anisotropy (FA), a...
An accurate estimate of preconception weight is necessary for providing a gestational gain range based on the Institute Medicine's guidelines; however, an and proximal not available most women. We examined validity first trimester weights estimating body mass index category. Under identical measurement conditions, two (i.e., 4–10 12 weeks gestation) were obtained (n = 43). The week correctly classified 95 91% women, respectively. Mean changes relatively small overall (M 0.74 ± 1.99 kg at M...
Maternal body composition, gestational weight gain (GWG) and diet quality influence offspring obesity risk. While the gut microbiome is thought to play a crucial role, it understudied in pregnancy. Using longitudinal pregnancy cohort, maternal anthropometrics, fecal dietary intake were assessed at 12, 24 36 weeks of gestation. Fecal samples (n = 101, 98 107, each trimester, respectively) utilized for analysis via 16S rRNA amplicon sequencing. Data included alpha- beta-diversity measures...
Introduction Maternal obesity is associated with increased concentrations of human milk (HM) obesogenic hormones, pro-inflammatory cytokines, and oligosaccharides (HMOs) that have been infant growth adiposity. The objective this pilot study was to determine if adherence a Mediterranean meal plan during lactation modulates macronutrients bioactive molecules in from mothers obesity. Methods Sixteen healthy, exclusively breastfeeding women (body mass index ≥30 kg/m 2 ) enrolled between 4 5...