A5037586311- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Digestive system and related health
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Child Nutrition and Water Access
- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Hepatitis Viruses Studies and Epidemiology
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Poxvirus research and outbreaks
- Intestinal Malrotation and Obstruction Disorders
- Milk Quality and Mastitis in Dairy Cows
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Clinical Nutrition and Gastroenterology
- Asthma and respiratory diseases
University of California, San Diego
2020-2025
Mothers’ Milk Bank
2024
Abstract Human Milk Oligosaccharides (HMOs) are abundant carbohydrates fundamental to infant health and development. Although these oligosaccharides were discovered more than half a century ago, their biosynthesis in the mammary gland remains largely uncharacterized. Here, we use systems biology framework that integrates glycan RNA expression data construct an HMO biosynthetic network predict glycosyltransferases involved. To accomplish this, models describing most likely pathways for...
Human milk is a complex and variable ecosystem fundamental to the development of newborns. This study aimed investigate relationships between human oligosaccharides (HMO) bacterial profiles infant body composition. samples (n = 60) were collected at two months postpartum. Infant maternal composition was measured with bioimpedance spectroscopy. assessed using full-length 16S rRNA gene sequencing 19 HMOs quantitated high-performance liquid chromatography. Relative abundance taxa significantly...
Synthetic human milk oligosaccharides (HMOs) are used to supplement infant formula despite limited understanding of their impact on the post-weaned developing gut microbiota. Here, we assess influence 0.5 g/L 2-fucosyllactose (2'FL) and 4.0 pooled HMOs (pHMOs) composition activity cultured fecal-derived microbial communities from seven healthy young children. Exposure pHMOs induced significant shifts in both community metabolic output, including an increased abundance several genera, notably...
Human milk oligosaccharide (HMO) composition varies throughout lactation and can be influenced by maternal characteristics. This study describes HMO variation up to three months postpartum explores the influences of sociodemographic anthropometric characteristics in a Brazilian prospective cohort. We followed 101 subjects from 28-35 gestational weeks (baseline) at 2-8 (visit 1), 28-50 2) 88-119 days 3). Milk samples were collected visits 1, 2 3, 19 HMOs quantified usinghigh-performance...
Human milk oligosaccharides (HMOs) are complex glycans that abundant in human milk. The potential impact of a maternal diet on individual HMOs and the association with secretor status is unknown. Thus, this study aimed to examine between HMO profiles.
Introduction Maternal obesity is associated with increased concentrations of human milk (HM) obesogenic hormones, pro-inflammatory cytokines, and oligosaccharides (HMOs) that have been infant growth adiposity. The objective this pilot study was to determine if adherence a Mediterranean meal plan during lactation modulates macronutrients bioactive molecules in from mothers obesity. Methods Sixteen healthy, exclusively breastfeeding women (body mass index ≥30 kg/m 2 ) enrolled between 4 5...
Human milk oligosaccharides (HMOs) are integral to infant health. Yet, their complex biosynthesis pathways in the mammary gland during lactation remain under characterized. To address this knowledge gap, we performed integrated analyses of single-cell RNA-sequencing (scRNA-seq) datasets combined with select HMO concentration measures. We identify differential expression patterns known synthesis genes epithelial subsets and nominate several candidate that vary concentration. Additionally,...
Temporal development of maternal and infant microbiomes during early life impacts short- long-term health. This study aimed to characterize bacterial dynamics within faecal, human milk (HM), oral, faecal samples the exclusive breastfeeding period document associations between oligosaccharide (HMO) intakes oral profiles. Maternal (n = 10) were collected at 2−5, 30, 60, 90 120 days postpartum full-length 16S ribosomal RNA (rRNA) gene was sequenced. Nineteen HMOs quantitated using...
Maternal behavior is necessary for optimal development and growth of offspring. The intestinal microbiota has emerged as a critical regulator in the early postnatal period life. Here, we describe identification an Escherichia coli strain that pathogenic to maternal-offspring system during stage life results stunting However, rather than having direct effect on infant, found this particular E. was dams by interfering with maturation maternal behavior. This resulted malnourishment pups...
Abstract Lactational mastitis is an excellent target to study possible interactions between HMOs, immune factors and milk microbiota due the infectious inflammatory nature of this condition. In work, microbiological, immunological HMO profiles samples from women with (MW) or without (HW) were compared. Secretor status in (based on profile) was not associated mastitis. DFLNH, LNFP II LSTb concentrations higher HW than MW among women. Milk characterized by a low bacterial load (dominated...
Human milk is a complex mix of nutritional and bioactive components that provide complete nutrition for the infant. However, we lack systematic knowledge factors shaping composition how variation influences infant health. Here, used multi-omic profiling to characterize interactions between maternal genetics, gene expression, composition, fecal microbiome in 242 exclusively breastfeeding mother-infant pairs. We identified 487 genetic loci associated with expression unique lactating mammary...
Growing evidence indicates that human milk oligosaccharides (HMOs) are important bioactive compounds enhance health and developmental outcomes in breastfed babies. Maternal dietary intake likely contributes to variation HMO composition, but studies identifying diet–HMO relationships few inconsistent. This study aimed investigate how the maternal of macronutrients micronutrients—specifically proteins, fats, vitamins, minerals—associated with HMOs at 1 month (n = 210), 6 months 131), 12...
Animal studies have shown that human milk oligosaccharides (HMOs) are important in early brain development, yet their roles not been assessed humans. The purpose of this study was to determine the associations HMOs with MRI indices tissue microstructure and regional cerebral blood flow (rCBF) infants. Mother-infant pairs (N = 20) were recruited at 1 month postpartum. Milk assayed for concentrations 2'-fucosyllactose (2'FL), 3-fucosyllactose (3FL), 3'-sialyllactose (3'SL), 6'-sialyllactose...
Human milk oligosaccharides (HMOs) are major components of human that may mediate its beneficial effects on infant growth. To investigate relationships between HMO concentrations in at 6 wk postpartum and anthropometry to 4 y age milk-fed infants. Milk samples were collected from 292 mothers (median 6.0 wk; range 3.3, 11.1] a longitudinal, population-derived cohort. Of the infants, 171 exclusively 3 mo 127 mo. Concentrations 19 HMOs quantified using high-performance liquid chromatography....
Some women produce antenatal colostrum during pregnancy and feed it to their baby after birth. However, the composition of how compares postnatal mature milk are not well described. In fact, there currently no data on when comes human oligosaccharides (HMOs), third most abundant solid component lactose lipids.
Breastfeeding and human milk (HM) improve maternal infant morbidities mortality. Therefore, monitoring the safety of breastfeeding access to HM is critical importance. In this study, we assessed tools monitor presence monkeypox virus (MPXV) in whether standard Holder pasteurization inactivates MPXV.
Human milk oligosaccharides (HMOs) are bioactive factors that benefit neonatal health, but little is known about effects on growth in very preterm infants (<32 weeks’ gestation). We aimed to quantify HMO concentrations human fed during the hospitalization and investigate associations of HMOs with infant size body composition at term-equivalent age. In 82 human-milk-fed infants, we measured two time points. anthropometrics air displacement plethysmography calculated means individual total...
Purpose: Recently, maternal nutrient intake has been associated with human milk oligosaccharides (HMOs) composition. The goal of this study was to assess HMO composition in breast samples from vegan, vegetarian, and nonvegetarian lactating women. Second, we assessed impact body mass index (BMI), age, parity, lactation stage on Materials Methods: A cross-sectional analysis vegan (n = 26), vegetarian 22), 26) women carried out. majority participants took dietary supplements. Results: In an...
Abstract Background One potential mechanism for protection from SARS-CoV-2 in children is through passive immunity via breast milk a mother infected with the novel coronavirus. The primary objectives of this study were to establish presence SARS-CoV-2-specific IgA and IgG characterize antigenic regions proteins that reactive antibodies milk. Methods Between March 2020 September 2020, 21 women confirmed infection enrolled Mommy’s Milk. Participants donated serial samples around their time...
Abstract Preterm infants are at a greater risk for the development of asthma and atopic disease, which can lead to lifelong negative health consequences. This may be due, in part, alterations that occur gut microbiome metabolome during their stay Neonatal Intensive Care Unit (NICU). To explore differential roles family history (i.e., predisposition due maternal diagnosis) hospital-related environmental clinical factors alter microbial exposures early life, we considered unique cohort preterm...