A5063822196- Birth, Development, and Health
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Gestational Diabetes Research and Management
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Reproductive Physiology in Livestock
- Diet and metabolism studies
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Infant Nutrition and Health
- Diet, Metabolism, and Disease
- Body Composition Measurement Techniques
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Obesity and Health Practices
- Thermoregulation and physiological responses
- Sperm and Testicular Function
- RNA Research and Splicing
- Lipoproteins and Cardiovascular Health
- Diabetes and associated disorders
Arkansas Children's Nutrition Center
2012-2025
Agricultural Research Service
2023-2024
University of Arkansas for Medical Sciences
2016-2024
United States Department of Agriculture
2024
Michigan State University
2017-2023
University of Colorado Denver
2021-2023
University of Colorado Anschutz Medical Campus
2021-2022
Megger (United Kingdom)
2019
University of Missouri
2008-2013
Harry S. Truman Memorial Veterans' Hospital
2013
Nonalcoholic fatty liver disease (NAFLD) is strongly linked to obesity, insulin resistance, and abnormal hepatic lipid metabolism; however, the precise regulation of these processes remains poorly understood. Here we examined genes proteins involved in oxidation lipogenesis 14-week-old leptin-deficient Ob/Ob mice, a commonly studied model obesity steatosis. Obese mice had increased fasting glucose, insulin, calculated HOMA-IR as compared with lean wild-type (WT) mice. also greater weights,...
It is hypothesized that obesity adversely affects the ovarian environment, which can disrupt oocyte maturation and embryonic development. This study aimed to compare gene expression profiles follicular fluid (FF) content from overweight/obese (OW) women normal-weight (NW) who were undergoing fertility treatments. Using single-cell transcriptomic analyses, we investigated using RNA sequencing. Eleven OW 13 NW treatments enrolled. Oocyte messenger as well serum FF hormone lipid levels...
Maternal obesity is an important determinant of offspring risk, which may be mediated via changes in the infant microbiome.We examined faecal microbiome, short-chain fatty acids (SCFA), and maternal human milk oligosaccharides (HMO) mothers with overweight/obese body mass index (BMI) (OW) compared normal weight (NW) (Clinicaltrials.gov NCT01131117).Infant stool samples at 1, 6, 12 months were analysed by 16S rRNA sequencing. (BODPOD) (quantitative nuclear magnetic resonance [QMR]) adiposity...
Maternal body composition, gestational weight gain (GWG) and diet quality influence offspring obesity risk. While the gut microbiome is thought to play a crucial role, it understudied in pregnancy. Using longitudinal pregnancy cohort, maternal anthropometrics, fecal dietary intake were assessed at 12, 24 36 weeks of gestation. Fecal samples (n = 101, 98 107, each trimester, respectively) utilized for analysis via 16S rRNA amplicon sequencing. Data included alpha- beta-diversity measures...
Rapid changes in the global climate are deepening existing health disparities from resource scarcity and malnutrition. Rising ambient temperatures represent an imminent risk to pregnant women infants. Both maternal malnutrition heat stress during pregnancy contribute poor fetal growth, leading cause of diminished child development low-resource settings. However, studies explicitly examining interactions between these two important environmental factors lacking. We leveraged neonatal...
Although obesity negatively influences the metabolic homeostasis of cells within a broad range tissues, its impact on oocyte metabolism is not fully understood. Prior evidence suggests that increases expression genes associated with inflammation, oxidative stress, and lipid metabolism; however, these genetic differences known. To address this gap, we conducted an exploratory assessment follicular fluid (FF) metabolome in eight overweight/obese (OW) nine normal-weight (NW) women undergoing...
Embryonic genome activation (EGA) in mammals begins with transient expression of a large group genes (EGA1). Importantly, entry into and exit from the 2C/EGA state is essential for viability. Dux family member play an integral role EGA1 by activating other EGA marker such as Zscan4 members. We previously reported that structural maintenance chromosomes flexible hinge domain-containing protein 1 (Smchd1) expressed at mRNA levels mouse oocytes early embryos elimination Smchd1 inhibits inner...
High follicle-stimulating hormone (FSH) doses during ovarian stimulation are detrimental to ovulatory follicle function and decrease live birth rate in cattle women. However, the mechanism whereby excessive FSH causes dysfunction is unknown. This study tested hypothesis that induces premature luteinization of ovulatory-size follicles. Small reserve heifers were injected twice daily for 4 days with 70 IU (N = 7 heifers) or 210 6 Folltropin-V [commercial FSH-enriched preparation porcine...
Rector, RS, Rogers, R, Ruebel, M, Widzer, MO, and Hinton, PS. Lean body mass weight-bearing activity in the prediction of bone mineral density physically active men. J Strength Cond Res 23(2): 427-435, 2009-Weight-bearing endurance resistance exercise are recommended to help preserve health during adulthood. However, effects training relative those often confounded by weight composition. The purpose this study was determine long-term running, cycling, on whole-body regional (BMD), adjusting...
Obesity impairs reproductive functions through multiple mechanisms, possibly disruption of ovarian function. We hypothesized that increased adiposity will lead to a proinflammatory gene signature and upregulation Egr-1 protein in ovaries from obese (OB; n = 7) compared with lean (LN; 10) female Sprague-Dawley rats during the peri-implantation period at 4.5 days postcoitus (dpc). was induced by overfeeding (40% excess calories for 28 days) via total enteral nutrition prior mating. OB dams had...
High follicle-stimulating hormone (FSH) doses during ovarian stimulation protocols for assisted reproductive technologies (ART) are detrimental to ovulatory follicle function and oocyte quality. However, the mechanisms unclear. In a small reserve heifer model, excessive FSH lead phenotypic heterogeneity of size follicles, with most follicles displaying signs premature luteinization range in severity abnormalities. By performing whole transcriptome analyses granulosa cells, cumulus oocytes...
Weight loss improves metabolic fitness and reduces morbidity mortality; however, weight reduction also bone mineral density (BMD) increases turnover. Weight-bearing aerobic exercise may preserve mass maintain normal turnover during reduction. We investigated the impact of weight-bearing nonweight-bearing on serum markers formation breakdown short-term, modest in overweight premenopausal women. Subjects (n = 36) were assigned to 1 3 weight-loss interventions designed produce a 5% body over 6...
Physical activity-induced prevention of hepatic steatosis is maintained during short-term (7-day) transitions to an inactive state; however, whether these protective effects are present under a longer duration physical inactivity largely unknown. Here, we sought determine previous activity had on and metabolic health following 4 wk inactivity. Four-week old, hyperphagic, male Otsuka Long-Evans Tokushima fatty (OLETF) rats were randomly assigned either sedentary group for 16 (OLETF-SED),...
Summary Background Maternal obesity increases offspring's risk. However, studies have not often considered maternal metabolic and exercise patterns as well paternal adiposity potential covariates. Objective To assess the relationship between parental newborn adiposity. Methods Participants were mother‐child pairs (n = 209) mother‐father‐offspring triads 136). Parental (during gestation) offspring (2 weeks old) percent fat mass (FM) obtained using air displacement plethysmography. race, age,...
Which different pathways and functions are altered in rhesus monkey oocytes that fail to mature after an ovulatory stimulus?Failed (FTM) complete a large portion of the transition transcriptome composition associated with normal maturation, but also manifest numerous differences indicate incomplete transcriptional repression cytoplasmic maturation affecting multiple processes.Oocyte defects contribute unexplained female infertility. Failure some undergo germinal vesicle breakdown or progress...
Abstract Excessive FSH doses during ovarian stimulation in the small reserve heifer (SORH) cause premature cumulus expansion and follicular hyperstimulation dysgenesis (FHD) nearly all ovulatory-size follicles with predicted disruptions cell-signaling pathways cells oocytes (before ovulatory hCG stimulation). These observations support hypothesis that excessive dysregulates cell function oocyte maturation. To test this hypothesis, we determined whether FSH-induced differentially expressed...
Objective This study investigated which antenatal and postnatal factors determine offspring adiposity during the first 2 years of life. Methods Participants were mother child pairs ( N = 224). Offspring percent fat mass (%FM) was obtained using quantitative nuclear magnetic resonance at 11 time points between ages 0.5 24 months. Independent variables included race, age, gestational weight gain, first‐trimester %FM, delivery mode, measures resting energy expenditure, respiratory exchange...