A5045266939- Urinary Tract Infections Management
- Bladder and Urothelial Cancer Treatments
- Cystic Fibrosis Research Advances
- Bacterial Infections and Vaccines
- Gut microbiota and health
- Enterobacteriaceae and Cronobacter Research
- Amino Acid Enzymes and Metabolism
- Antibiotic Resistance in Bacteria
- Heme Oxygenase-1 and Carbon Monoxide
- Redox biology and oxidative stress
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Proteoglycans and glycosaminoglycans research
- Urinary Bladder and Prostate Research
- Viral Infections and Vectors
- Inhalation and Respiratory Drug Delivery
- Metabolism and Genetic Disorders
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Probiotics and Fermented Foods
- Effects of Environmental Stressors on Livestock
- Folate and B Vitamins Research
University at Buffalo, State University of New York
2022-2024
University of Alabama at Birmingham
2019-2022
Cystic Fibrosis Foundation
2021
Pulmonary and Allergy Associates
2021
London Chest Hospital
1985
Four patients with cystic fibrosis diagnosed in middle and later life are presented. All had chronic bronchopulmonary infection a high sweat sodium concentration, chest radiographic evidence of upper zone bronchiectasis. Two pancreatic dysfunction. Sputum culture grew mucoid Pseudomonas aeruginosa three Haemophilus influenzae one. Ages at diagnosis were 63, 42, 40, 35 years. These confirm the possibility occasional longevity emphasise need to consider all ages. They also provide...
ABSTRACT Biofilms play an important role in the development and pathogenesis of catheter-associated urinary tract infection (CAUTI). Proteus mirabilis Enterococcus faecalis are common CAUTI pathogens that persistently co-colonize catheterized form biofilms with increased biomass antibiotic resistance. In this study, we uncover metabolic interplay drives biofilm enhancement examine contribution to severity. Through compositional proteomic analyses, determined increase stems from protein...
Summary Polymicrobial biofilms play an important role in the development and pathogenesis of CAUTI. Proteus mirabilis Enterococcus faecalis are common CAUTI pathogens that persistently co-colonize catheterized urinary tract form with increased biomass antibiotic resistance. In this study, we uncover metabolic interplay drives biofilm enhancement examine contribution to severity. Through compositional proteomic analyses, determined increase stems from protein fraction polymicrobial matrix. We...
Proteus mirabilis is a common cause of urinary tract infection, especially in catheterized individuals. Amino acids are the predominant nutrient for bacteria during growth urine, and our prior studies identified several amino acid import catabolism genes as fitness factors P. catheter-associated infection (CAUTI), particularly those d- l-serine. In this study, we sought to determine hierarchy utilization by examine relative importance vs l-serine critical steps CAUTI development progression....
Non-typeable Haemophilus influenzae (NTHi) is a common inhabitant of the human nasopharynx and upper airways that can cause opportunistic infections airway mucosa including bronchopulmonary in patients with chronic obstructive pulmonary disease (COPD). It clear contribute significantly to inflammatory exacerbations COPD; however, there remains much be learned regarding specific host microbial determinants persistence and/or clearance this context.In study, we used recently described ferret...
Patients with cystic fibrosis (CF) experience lifelong respiratory infections, which are a significant cause of morbidity and death. These infections polymicrobial in nature, the predominant bacterial species undergo predictable series changes as patients age. Young have populations dominated by opportunists that typically found within microbiome human nasopharynx, such nontypeable Haemophilus influenzae (NTHi); these eventually supplanted, population CF lung is later pathogens Pseudomonas...
Smoke exposure is a risk factor for community-acquired pneumonia, which typically caused by host-adapted airway opportunists like nontypeable Haemophilus influenzae (NTHi). Genomic analyses of NTHi revealed homologs enzymes with predicted roles in reduction protein thiols, can have key oxidant resistance. Using clinical isolate (NTHi 7P49H1), we generated isogenic mutants glutathione reductase (open reading frame NTHI 0251), thioredoxin-dependent thiol peroxidase (NTHI 0361), 0907),...
is a common cause of healthcare acquired bloodstream infections and catheter associated urinary tract (CAUTI) in both adults children. Treatment
ABSTRACT Enterococcus faecalis is a common cause of healthcare-acquired bloodstream infections and catheter-associated urinary tract (CAUTIs) in both adults children. Treatment E. infection frequently complicated by multi-drug resistance. Based on protein homology, encodes two putative hyaluronidases, EF3023 (HylA) EF0818 (HylB). In other Gram-positive pathogens, hyaluronidases have been shown to contribute tissue damage immune evasion, but the function has yet be explored. Here, we show...
Summary Proteus mirabilis is a common cause of urinary tract infection, especially in catheterized individuals. Amino acids are the predominant nutrient for bacteria during growth urine, and our prior studies identified several amino acid import catabolism genes as fitness factors P. catheter-associated infection (CAUTI), particularly D- L-serine. In this study, we sought to determine hierarchy utilization by examine relative importance vs L-serine critical steps CAUTI development...
ABSTRACT Patients with cystic fibrosis (CF) experience lifelong respiratory infections which are a significant cause of morbidity and mortality. These polymicrobial in nature, the predominant bacterial species undergo predictable series changes as patients age. Young have populations dominated by opportunists that typically found within microbiome human nasopharynx, such nontypeable Haemophilus influenzae (NTHi); these eventually supplanted population CF lung is later pathogens Pseudomonas...
Abstract Smoke exposure is a risk factor for community acquired pneumonia, which typically caused by host adapted opportunists like nontypeable Haemophilus influenzae (NTHi). Genomic analyses of NTHi revealed homologs enzymes involved in thiol metabolism, can have key roles oxidant resistance. Using clinical isolate (NTHi 7P49H1), we generated isogenic mutant bacterial strains glutathione reductase (NTHI 0251), peroxidase 0361), 0907), thioredoxin 1327) and glutaredoxin/peroxiredoxin 0705)...