A5064372009- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Drug Transport and Resistance Mechanisms
- Hormonal and reproductive studies
- Pediatric Hepatobiliary Diseases and Treatments
- Pharmacological Effects and Assays
- Metabolomics and Mass Spectrometry Studies
- Hypothalamic control of reproductive hormones
- Environmental Toxicology and Ecotoxicology
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Steroid Chemistry and Biochemistry
- Chromosomal and Genetic Variations
- Liver Disease and Transplantation
- Animal Behavior and Reproduction
- Genetic diversity and population structure
- Congenital heart defects research
- Birth, Development, and Health
- Marine animal studies overview
- Organ Transplantation Techniques and Outcomes
- Estrogen and related hormone effects
- Congenital Anomalies and Fetal Surgery
Michigan State University
2014-2024
Michigan Department of Natural Resources
2004-2021
Michigan United
2019
Louisiana Department of Wildlife and Fisheries
2012
Jeramiah Smith, Weiming Li and colleagues report the whole-genome sequence of sea lamprey, Petromyzon marinus, representing a vertebrate lineage diverged from humans ~500 million years ago. Their analyses define key evolutionary events in lineages provide evidence for two duplication occurring before divergence ancestral lamprey jawed (gnathostome) lineages. Lampreys are representatives an ancient that our own ∼500 By virtue this deeply shared ancestry, (P. marinus) genome is uniquely poised...
Semen is fundamental for sexual reproduction. The non-sperm part of ejaculated semen, or seminal plasma, facilitates the delivery sperm to eggs. plasma some species with internal fertilization contains anti-aphrodisiac molecules that deter promiscuity in post-copulatory females, conferring fitness benefits ejaculating male. By contrast, taxa external such as fish, exposure semen promotes spawning behaviors. However, no specific compounds have been identified aphrodisiac pheromones. We sought...
In gnathostomes, chemosensory receptors (CR) expressed in olfactory epithelia are encoded by evolutionarily dynamic gene families encoding odorant (OR), trace amine-associated (TAAR), V1Rs and V2Rs. A limited number of OR-like sequences have been found invertebrate chordate genomes. Whether these arose basal or advanced vertebrates has not resolved because examined systematically agnathan Petromyzon is the only extant jawless vertebrate whose genome sequenced. Known to be exquisitely...
Bile salt synthesis is a specialized liver function in vertebrates. salts play diverse roles digestion and signaling, their homeostasis maintained by controlling input (biosynthesis) intestinal conservation. Patients with biliary atresia (i.e., obliteration of the tree) suffer fibrosis cirrhosis. In contrast, sea lamprey thrives despite developmental atresia. We discovered that adapts to through unique mechanism de novo secretion bile intestine after atresia, addition known mechanisms, such...
Abstract Goldfish is an ornamental fish with diverse phenotypes. However, the limited genomic resources of goldfish hamper our understanding genetic basis for its phenotypic diversity. To provide enriched and infer possible mechanisms underlying skin pigmentation, we performed a large-scale transcriptomic sequencing on 13 adult tissues, larvae at one- three-days post hatch, tissues four different color pigmentation. A total 25.52 Gb 149.80 clean data were obtained using PacBio Illumina...
Abstract Background In vertebrates, bile salts are primarily synthesized in the liver and secreted into intestine where they aid absorption of dietary fats. Small amounts that not reabsorbed enterohepatic circulation excreted with waste. sexually mature male sea lamprey ( Petromyzon marinus L.) a salt is released large across gill epithelia water it functions as pheromone. We postulate release this pheromone associated dramatic increase its biosynthesis transport to gills upon sexual...
Lampreys are extant representatives of the jawless vertebrate lineage that diverged from jawed vertebrates around 500 million years ago. Lamprey genomes contain information crucial for understanding evolution gene families in vertebrates. The ATP-binding cassette (ABC) family is found prokaryotes to eukaryotes. recent availability two lamprey draft sea Petromyzon marinus and Japanese Lethenteron japonicum presents an opportunity infer early evolutionary events ABC genes vertebrates.We...
Many environmental pollutants induce expression of the cytochrome P450 (CYP) 1A subfamily genes. We integrated cellular and molecular biological techniques to examine effects beta-naphthoflavone (BNF) exposure in lake trout brain CYP1A distribution dynamics. Over a 32-day time-course, real time quantitative reverse transcription polymerase chain reaction (Q-RT-PCR) results showed that mRNA induction response BNF occurred rapidly continued rise BNF-treated after 4 h, with peak at or 2 days....
Goldfish ( Carassius auratus ) use reproductive hormones as endocrine signals to synchronize sexual behavior with gamete maturation and exogenous (pheromones) mediate spawning interactions between conspecifics. We examined the differential effects of two hormonal pheromones, prostaglandin F 2α (PGF 17α,20β-dihydroxy-4-pregnen-3-one (17,20β-P) on neurogenesis, neurotransmission, neuronal activities, plasma androstenedione (AD) levels. Exposure waterborne PGF induced a multitude changes in...
Abstract Background Vertebrate pheromones are known to prime the endocrine system, especially hypothalamic-pituitary-gonadal (HPG) axis. However, no pheromone molecule has been shown modulate directly synthesis or release of gonadotropin releasing hormone (GnRH), main regulator HPG We selected sea lamprey ( Petromyzon marinus ) as a model system determine whether single component alters output GnRH. Sea male sex contain component, 7α, 12α, 24-trihydroxy-5α-cholan-3-one 24-sulfate (3...
Abstract Background A dual olfactory system, represented by two anatomically distinct but spatially proximate chemosensory epithelia that project to separate areas of the forebrain, is known in several classes tetrapods. Lungfish are earliest evolving vertebrates have this comprising a main and vomeronasal system (VNO). Lampreys, group jawless vertebrates, single nasal capsule containing epithelia, (MOE) accessory (AOE). We speculated lamprey AOE projects specific telencephalic regions as...
(+)- and (−)-Petromyroxol [(+)-1 (−)-1, respectively], two novel tetrahydrofuran (THF)-diol fatty acid enantiomers, were isolated from water conditioned with larval sea lamprey. We herein describe their isolation subsequent resolution using chiral chromatography. The absolute configuration of each enantiomer was determined by a combination Mosher ester analysis comparison related natural synthetic products. Electro-olfactogram (EOG) assays indicated that (+)-petromyroxol (1) possesses potent...
Nuclear progesterone receptor (nPR) is an evolutionary innovation in vertebrates that mediates genomic responses to progesterone. Vertebrates also respond via membrane receptors (mPRs) or associated (MAPRs) through rapid nongenomic mechanisms. Lampreys are extant agnathan vertebrates, residing at the juncture where diverged from invertebrates. A survey of (PR) gene sequences lamprey genomes would inform PR events during transition invertebrates vertebrates. In this study, we annotated one...