A5108057503- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- T-cell and Retrovirus Studies
- Mercury impact and mitigation studies
- Melamine detection and toxicity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- Plant-Microbe Interactions and Immunity
- Cancer, Hypoxia, and Metabolism
- Lymphadenopathy Diagnosis and Analysis
- Adenosine and Purinergic Signaling
- Molecular Biology Techniques and Applications
- Microbial infections and disease research
- Cancer Genomics and Diagnostics
- Calcium signaling and nucleotide metabolism
- Plant Parasitism and Resistance
- Genetic factors in colorectal cancer
- Animal Diversity and Health Studies
- interferon and immune responses
- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Immune cells in cancer
Zhongnan Hospital of Wuhan University
2022-2025
Wuhan University
2020-2025
Nanjing Medical University
2016-2025
Jiangsu Cancer Hospital
2016-2023
Shanghai Jiao Tong University
2017-2021
Jilin Academy of Agricultural Sciences
2012-2021
Shanghai Children's Hospital
2021
Renji Hospital
2017
Huazhong Agricultural University
2016
Second Affiliated Hospital of Nanjing Medical University
2016
Abstract Plant-parasitic nematodes cause serious crop losses worldwidely. This study intended to discover the antagonistic mechanism of Bacillus cereus strain S2 against Meloidogyne incognita . Treatment with B. resulted in a mortality 77.89% Caenorhabditis elegans (a model organism) and 90.96% M. In pot experiment, control efficiency culture or supernatants were 81.36% 67.42% towards , respectively. field was 58.97% Nematicidal substances isolated from supernatant by polarity gradient...
Abstract Skeletal stem cells (SSCs) maintain the skeletal system via pluripotency and differentiation capacity. However, it remains largely unknown how these precisely regulate their function to organization. Here, we delineate RNA m 6 A modification landscape across cell populations in mouse epiphysis. Our findings show that modifications are prevalent progenitor play critical roles fate determination. Genetic deletion of Mettl3, core catalytic subunit A-methyltransferase complex, murine...
Objective: To analyze the clinical characteristics of plastic bronchitis (PB) in children with Mycoplasma pneumoniae pneumonia (MPP) order to explore its risk factors. Methods: A retrospective analysis was performed MPP receiving bronchoscopy admitted department respiratory medicine Shanghai Children's Hospital from January 2018 December 2020. According bronchoscopic findings, patients were divided into PB group and non-PB group. The manifestations, laboratory examination, etiology,...
// Yuan Mao 1, 2, 3, * , Jun Wang Mingzhi Zhang 4 Weifei Fan 3 Qi Tang 5 Siping Xiong Xiaojun Juqing Xu Lin Shu Yang Suyao Liu Li 6 Yan Chen 2 Rong Yin Jin Zhu 7 1 Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory Molecular and Translational Research, Institute Province, Nanjing, China The Fourth Clinical College University, Hematology Oncology, Geriatric Lung Laboratory, Province First Hospital Zhengzhou Zhengzhou, Pathology...
NAD+ metabolism is involved in many biological processes. However, the underlying mechanism of how regulated remains elusive. Here, we find that PTIP governs macrophages by regulating CD38 expression and required for macrophage inflammation. Through integrating histone modifications with metabolic gene profiling, identify as a key factor expression, primary NAD+-consuming enzyme macrophages. Interestingly, deletion impairs proinflammatory response murine human macrophages, promotes their...
Abstract Hematopoietic homeostasis is maintained by hematopoietic stem cells (HSCs), and it tightly controlled at multiple levels to sustain the self-renewal capacity differentiation potential of HSCs. Dysregulation HSCs leads development hematologic diseases, including acute myeloid leukemia (AML). Thus, understanding underlying mechanisms HSC maintenance malignancies one fundamental scientific endeavors in cell biology. N 6-methyladenosine (m6A) a common modification mammalian messenger...
Objective. To investigate the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in serum, bronchoalveolar lavage fluid (BALF), endotracheal aspiration (ETA), and exhaled breath condensate (EBC) samples as early biomarkers for diagnosis ventilator-associated pneumonia (VAP) patients with ischemic stroke. Methods. One hundred thirty-two clinically suspected VAP were enrolled this study. Bronchoscopy was performed day VAP. sTREM-1 levels BALF, ETA, EBC measured....
N6-Methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m6A a key role hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress detecting transcriptome-wide manner. In this review, we first briefly summarize latest advances biology by focusing on writers, readers,...
Glaesserella parasuis (G. parasuis) has been one of the bacteria affecting large-scale swine industry. Lack an effective vaccine limited control disease, which effect on prevalence. In order to improve cross-protection vaccines, development subunit vaccines become a hot spot. this study, we firstly cloned lpxC and gmhA genes from G. serotype 13 isolates, expressed purified their proteins. The results showed that LpxC GmhA can stimulate mice produce IgG antibodies. Through testing cytokine...
Hepatitis C remains a major public health problem in the world. The host immune system plays key role viral clearance. This study aimed to investigate connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor polymorphism and hepatitis chronicity Chinese Han population. current genotyped three SNPs (IFIH1 rs10930046 DHX58 rs2074158 , rs2074160 ) assess their association with of virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases 1,000...
3038 Background: Non-small-cell lung cancer (NSCLC) is the leading cause of worldwide cancer-related deaths. Currently, ̃30-55% NSCLC patients develop recurrence due to minimal residual disease (MRD) after receiving surgical resection tumor. Therefore, there an urgent clinical need accurately predict MRD risk in post-surgical patients. However, current targeted ctDNA mutation profiling method limited by cost design and synthesis patient-specific panels relatively low sensitivity. Cell-free...