A5101424329- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Plant Physiology and Cultivation Studies
- Remote Sensing and Land Use
- Horticultural and Viticultural Research
- Cancer, Lipids, and Metabolism
- Plant responses to water stress
- Sugarcane Cultivation and Processing
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Food Quality and Safety Studies
- Breast Cancer Treatment Studies
- Nuts composition and effects
- Thyroid Cancer Diagnosis and Treatment
- Plant and Fungal Interactions Research
- Cancer Genomics and Diagnostics
- Plant Ecology and Soil Science
- Neurological Disease Mechanisms and Treatments
- Environmental and Agricultural Sciences
- Circular RNAs in diseases
- Plant Water Relations and Carbon Dynamics
- Advanced Breast Cancer Therapies
- Plant Stress Responses and Tolerance
- Bioinformatics and Genomic Networks
- Immune cells in cancer
Hebei North University
2020-2025
Fudan University
2025
University College Birmingham
2025
University of Birmingham
2025
Sun Yat-sen University
2025
University of Hong Kong
2025
Zhongshan Hospital
2025
Nanjing Medical University
2021-2024
Jiangsu Cancer Hospital
2020-2024
Nantong University
2023
Abstract Background Breast cancer (BC) is the most common malignancy in women, yet role of beverage consumption BC risk remains unclear. Additionally, contribution anthropo-metabolic biomarkers as mediators unknown, limiting development effective prevention strategies. Methods This study included 13,567 participants from Guangzhou Biobank Cohort Study (GBCS), where was assessed at baseline using a food frequency questionnaire. cases were identified through registry linkage over mean...
Previous studies have found that Apolipoprotein E (APOE) plays a crucial role in invasion and migration of papillary thyroid carcinoma (PTC) cells enhance M2 macrophage polarization. Ferroptosis has been implicated development various tumors their treatment resistance, shown APOE is involved ferroptosis regulation. However, whether promotes PTC progression through modulation remains unclear. This study aims to investigate the ferroptosis-related mechanisms which facilitates cell invasion,...
Background: Recent research showed that abnormal lipid metabolism was associated with cancers. As one of the genes can regulate level metabolism, APOE expression carcinogenesis. However, clinical value in papillary thyroid carcinoma (PTC) remains to be determined. Methods: ONCOMINE, GEPIA, UALCAN, STRING, GeneMANIA, LinkedOmics, GSCALite, TISIDB, EPIC and TIMER were utilized achieve comprehensively bioinformatics analysis this study. And immunohistochemical staining used verify predicted...
PANoptosis is a newly recognized inflammatory pathway for programmed cell death (PCD). It participates in regulating the internal environment, homeostasis, and disease process various complex ways plays crucial role tumor development, but its mechanism of action still unclear. In this study, we comprehensively analyzed expression 14 PANoptosis-related genes (PANRGs) 28 types tumors. Most PANRGs are upregulated tumors, including Z-DNA binding protein 1 (ZBP1), nucleotide-binding...
As metastatic papillary thyroid carcinoma becomes increasingly challenging to treat, immunotherapy has emerged as a new research direction. Tumor-associated macrophages (TAMs) influence the occurrence, invasion, and metastasis of tumors. Apolipoprotein E (APOE) can regulate polarization changes participate in remodeling tumor microenvironment. However, role APOE regulating biological functions TAMs (PTC) remains unclear, it acts dual biomarker. We probed expression PTC tissues using...
Background: KCNKs, potassium two pore domain channel family K members, can maintain the resting potential, regulate amplitude and duration of plateau action change membrane potential excitability. Evidence from many studies indicates that KCNKs is abnormally expressed in solid tumors plays a regulatory role development malignant progression cancer. However, expression pattern prognostic value KCNK factors papillary thyroid carcinoma have not been reported. Methods: In this study, we used...
Abstract Background: Papillary thyroid carcinoma (PTC) is one of the fastest-growing malignant tumor types cancer. Therefore, identifying interaction genes in PTC crucial for elucidating its pathogenesis and finding more specific molecular biomarkers. Methods: Four pairs tissues adjacent were sequenced using RNA-Seq, 3745 differentially expressed screened (P<0.05, |logFC|>1). The enrichment analysis indicated that vast majority (DEGs) may play a positive role development Then,...
Due to the heterogeneity of hepatocellular carcinoma (HCC), hepatocelluarin-associated differentially expressed genes were analyzed by bioinformatics methods screen molecular markers for HCC prognosis and potential targets immunotherapy.RNA-seq data clinical follow-up downloaded from The Cancer Genome Atlas (TCGA) database. Multivariate Cox analysis Lasso regression used identify robust immunity-related genes. Finally, a risk model immune gene pairs was established verified features, test...
In recent years, the annual incidence of thyroid cancer (TC) has increased, with papillary (PTC) identified as most commonwinwordpathological type accounting for approximately 80% all cases. The tumor microenvironment is known to play a vital role in information transmission and immune detection.In present study, we examined gene expression data from 518 patients PTC. ESTIMATE algorithm was used calculate stromal scores PTC patients. Based on protein-protein interaction (PPI) network,...
Ankyrin repeat and SOCS Box containing 3 (ASB3) is an E3 ubiquitin ligase. It has been reported to regulate the progression of some cancers, but no systematic pan-cancer analysis conducted explore its function in prognosis immune microenvironment.In this study, mRNA expression data were downloaded from TCGA GTEx database. Next generation sequencing 14 glioblastoma multiforme (GBM) samples by neurosurgical resection used as validation dataset. Multiple bioinformatics methods (ssGSEA,...
摘要: 江汉盆地西部和东部分布的宜昌和阳逻砾石层是否和长江的演化发育有关,目前一直存有争议.基于此,我们对宜昌和阳逻砾石层开展碎屑锆石U-Pb年龄分析,同时对宜昌砾石层近源的沮漳河和清江,以及阳逻砾石层周边的汉江、澴水、倒水和举水开展碎屑锆石U-Pb年龄测试,共取得654个新锆石U-Pb年龄数据.结合区域内砾石层的堆积时代和已报道的长江上游碎屑锆石U-Pb年龄结果,系统判定宜昌和阳逻砾石层的物源区.结果表明,长江至少在1.2~0.7 Ma和1.3 Ma成为宜昌和阳逻砾石层的砂层物质供给河流.通过和长江上游、下游同期砾石层对比,以及河流物源示踪结果,说明串联上游、中游和下游的长江在早更新世稳定出现,是对青藏高原隆升和东亚夏季风增强的响应.因而,东亚地区早更新世持续的构造过程和环境变化共同作用,对孕育长度超过6 000 km的大陆尺度的长江的稳定出现至关重要. 关键词: 长江 / 锆石 砾石层 物源示踪 U-Pb年龄 第四纪地质 环境地质
To study the effect of abnormal intestinal flora on risk colorectal cancer and heparin formation bacterial biofilm, 50 patients with healthy subjects were selected. The distribution quantity bacteria in feces, levels D-lactic acid endotoxin serum two groups detected. Intestinal strains biofilm growth also detected cultured different concentrations (0 mg/mL, 5 mg /mL, 10 20 mg/mL). results showed that there was significant difference number major between before after operation (P < 0.05)....