A5026905025- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Pelvic and Acetabular Injuries
- Scoliosis diagnosis and treatment
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Anesthesia and Pain Management
- Bone and Joint Diseases
- Infectious Diseases and Tuberculosis
- Acupuncture Treatment Research Studies
- Microbial Metabolism and Applications
- Education and Work Dynamics
- Nutrition and Health in Aging
- Higher Education and Teaching Methods
- Nausea and vomiting management
- Osteomyelitis and Bone Disorders Research
- Myofascial pain diagnosis and treatment
- Surface Modification and Superhydrophobicity
- Tendon Structure and Treatment
- Aerogels and thermal insulation
- Enhanced Recovery After Surgery
- Pain Management and Treatment
- Osteoarthritis Treatment and Mechanisms
Tongde Hospital of Zhejiang Province
2016-2025
Zhejiang Hospital
2022
Guangzhou University
2011
Intervertebral disc degeneration (IVDD) is commonly associated with many spinal problems, such as low back pain, and significantly impacts a patient's quality of life. However, current treatments for IVDD, which include conservative surgical methods, are limited in their ability to fully address degeneration. To combat delivery-system-based therapy has received extensive attention from researchers. These delivery systems can effectively deliver therapeutic agents overcoming the limitations...
Background: Immune cells play a pivotal role in maintaining ovarian function. However, the specific contributions of different immune cell phenotypes to pathogenesis ovarian-related diseases remain poorly understood. We aim investigate correlation between 731 immunophenotypes and diseases. Materials Methods: Utilizing publicly available genetic data, we undertook series quality control measures identify instrumental variables (IVs) associated with exposure. Subsequently, conducted two-sample...
Intervertebral disc degeneration disease (IDD) is one of the leading causes disability, and current therapies are ineffective. Phosphodiesterase 4B (PDE4B) plays essential roles in regulating activation NLRP3 inflammasome. However, whether PDE4B or involved development IDD unclear. This study sought to explore role pathogenesis by vivo vitro experiments. results showed that were significantly upregulated nucleus pulposus (NP) tissues from IDD-related human patients. Deletion NP resulted...
Study Design. A prospective randomized controlled trial. Objective. The purpose of this study was to evaluate the clinical effect and safety a new multimodal nutritional management (MNM) protocol for patients receiving primary lumbar spine surgery. Summary Background Data. Poor status is common in perioperative period surgery, may impede recovery after Methods. total 187 were included They randomly assigned MNM group or control group. Albumin (ALB) infusion, postoperative ALB level,...
Introduction: Nerve injury is a serious complication of percutaneous endoscopic transforaminal lumbar discectomy due to nerve root contact. The maximum tolerable concentration (MTC) ropivacaine for epidural anaesthesia, defined as the that minimises pain while preserving sensation roots. This distinct advantage allows patient provide feedback surgeon when roots are contacted. Methods: We used biased-coin design determine MTC, which was estimated by 10% effective (EC 10 ), ie, at patients...
Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and still without effective treatment method. This study aimed at evaluating combined pharmacotherapy with alendronate desferoxamine preventing glucocorticoid-induced osteonecrosis (GIOFH) efficacy medicine in regulating bone resorption regeneration.Thirty-six rats were randomly assigned to three groups: group A received (n = 12), B only C acted as control placebo 12). All induced GIOFH using methylprednisolone...
Low levels of inflammation-induced expression matrix metalloproteinase (MMP) play a crucial role in articular cartilage destruction osteoarthritis (OA) patients. Interferon regulatory factor-8 (IRF-8), an important member the IRF family, plays key regulating inflammation-related signaling pathway. The aim this study is to investigate physiological roles IRF-8 pathological progression OA. We found that was expressed human primary chondrocytes. Interestingly, upregulated OA In addition,...
Lumbar disc herniation (LDH) is a frequently occurring disease with unknown etiology, which makes treatment challenge. The aim of this study was to analyze the effects dexamethasone on LDH and elucidate underlying mechanisms.An rat model established by nucleus pulposus implantation. activity lipocalin type prostaglandin D synthase (L-PGDS)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) axis evaluated Western blotting. Paw withdrawal threshold paw latency were assessed Von Frey hairs...
Background: Most clinical reports on the surgical treatment of kümmell disease lack consistency between classification and protocol. In this study, we investigate most appropriate effective strategies according to characteristics different types Kümmell disease.
Abstract Background We studied the characteristics and regularity of appropriate insertion points for percutaneous pedicle screw placement in lumbar spine using C-arm X-ray fluoroscopy. The purpose this study was to improve accuracy reduce incidence superior-level facet joint violation. Methods Six normal spinal specimens were included. Three different methods placing screws applied, including Roy-Camille method, Magerl method Weinstein method. relationships among point, projection proximal...
Background With the development of modern society, severe and complex tibial fractures caused by high-energy injuries such as traffic accidents have gradually increased. At present, commonly used methods for treatment include plate fixation, intramedullary nail external fixation. Most these are open wounds with soft tissue injury wound contamination, some involve bone defects, which makes internal fixation difficult. Objective This study aims to explore use intelligent computer-assisted...
Abstract This study investigated the function of telomerase RNA component (TERC) in spinal cord injury (SCI). SCI models were established rats via laminectomy and PC-12 cells treated with lipopolysaccharide (LPS). TERC miR-34a-5p expressions rat cords detected by quantitative reverse transcription polymerase chain reaction, followed overexpression/knockdown TERC/miR-34a-5p. Spinal histopathological changes examined hematoxylin–eosin staining. miR-34a-5p′ relation XBP-1 was predicted...
To investigate the effectiveness of unilateral biportal endoscopy (UBE) technique in treatment high-grade migrated lumbar disc herniation (LDH).Between January 2020 and February 2021, 23 cases LDH were treated with discectomy via UBE. There 14 males 9 females, a mean age 48.7 years (range, 32-76 years). All patients had low back leg pain. The disease duration ranged from 2 months to 7 (median, 13 months). Lesion segments L 3, 4 cases, 4, 5 15 5, S 1 6 cases. operation time, intraoperative...
The main objective of this study is to explore the effects tetramethylpyrazine on functional recovery, inflammation and apoptosis after spinal cord injury in rats. Four experimental groups rats were used (n=15), which included sham+vehicle group where only laminectomy was performed, sham+tetramethylpyrazine injury+vehicle induced through clip compression technique injury+tetramethylpyrazine induced. control given same dose normal saline four intervened under conditions, intraperitoneally...
Objective To explore the positive rate and identify risk factors of methicillin-resistant Staphylocoaus aureus (MRSA) in surgical patients. Methods The MRSA screening for nose, pharynx wound secretion were performed patients with elective surgery Tongde Hospital Zhejiang Province. Polymerase chain reaction (PCR) was used testing. According to result, single factor analysis multiple stepwise logistic regression predict factors. Results A total 1 755 screened from April 2016...
目的 探讨耐甲氧西林金黄色葡萄球菌(Methicillin-resistant Staphylococcus aureus，MRSA)主动筛查及综合防控对外科手术患者MRSA感染控制的作用。 方法 选取2016年1月至2018年12月浙江省立同德医院外科的12 606例患者为研究对象。以2017年1月至2018年12月入院的8 700例患者为干预组，实施MRSA主动筛查，并对筛查结果阳性的患者进行综合防控措施的干预。以2016年1月至12月入院的3 906例患者为常规对照组。比较两组患者清洁切口手术部位感染率、清洁切口手术部位各类细菌感染发生率、预防抗菌药物使用率的情况。采用SPSS...
Abstract Background: We studied the characteristics and regularity of appropriate insertion points for percutaneous pedicle screw placement in lumbar spine using C-arm X-ray fluoroscopy. The purpose this study was to improve accuracy reduce incidence superior-level facet joint violation. Methods: Six normal spinal specimens were included. Three different methods placing screws applied, including Roy-Camille method, Magerl method Weinstein method. relationships among point, projection...
<sec> <title>UNSTRUCTURED</title> The retrospective study of Taylor's three-dimensional external fixator for the treatment tibiofibular fractures provides a theoretical basis application this technology. paper collected 28 patients with from Department Orthopaedics in our hospital March 2015 to June 2018. After treatment, follow-up evaluation and concurrency incidence disease, as well efficacy occurrence internal fixation tibial hospital. results showed that was superior orthopaedics terms...
Abstract Background: We studied the characteristics and regularity of appropriate insertion points for percutaneous pedicle screw placement in lumbar spine using C-arm X-ray fluoroscopy. The purpose this study was to improve accuracy reduce incidence superior-level facet joint violation. Methods: Six normal spinal specimens were included. Three different methods placing screws applied, including Roy-Camille method, Magerl method Weinstein method. relationships among point, projection...