A5100609911- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Erythrocyte Function and Pathophysiology
- Knee injuries and reconstruction techniques
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Probiotics and Fermented Foods
- Shoulder and Clavicle Injuries
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Inflammatory mediators and NSAID effects
- Ion channel regulation and function
- Genomics, phytochemicals, and oxidative stress
- Traditional Chinese Medicine Studies
- Blood properties and coagulation
- MicroRNA in disease regulation
- Anesthesia and Pain Management
- Cardiovascular Function and Risk Factors
- Nerve Injury and Rehabilitation
- Shoulder Injury and Treatment
- Hepatitis C virus research
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Studies on Chitinases and Chitosanases
Zhejiang University
2023-2025
Kunming University of Science and Technology
2025
Jinhua Central Hospital
2017-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Rotator cuff tear (RCT) is a common musculoskeletal disease that poses challenges for functional regeneration of the tendon-bone interface (TBI). The transition TBI between soft and hard tissues determines its structural physiological environment complexity. Here, we present an injectable biopiezoelectric material PVA/CNF/BTO@PDA (Piezoelectric) hydrogel based on three-dimensional (3D) printing inspired by "muscle-electrical coupling". This Piezoelectric indicated desirable piezoelectric...
The aim of the study was to explore mechanism excessive apoptosis nucleus pulposus cells induced by short hairpin RNA (shRNA) Piezo type mechanosensitive ion channel component 1 (Piezo1) under abnormal mechanical stretch stress.In vitro stress model in established, which expression Piezo1 interfered transfection shRNA-Piezo1 interfering vector. Both messenger and protein level were measured reverse-transcription polymerase chain reaction Western blot analysis, respectively. Cytoplasmic Ca2+...
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovitis, systemic inflammation, and autoantibody production. This study aims to explore the role of lactylation in plasma cells its impact on RA pathogenesis.
Abstract Osteoarthritis (OA) is the most common degenerative joint disease and results from progressive loss destruction of articular cartilage underlying bone. The affects millions people worldwide with an associated risk mobility disability. However, molecular basis OA initiation progression not well understood and, currently, there no effective intervention available to decelerate or restore degraded cartilage. We have found that lncRNA long intergenic nonprotein coding RNA 341...
Osteoarthritis (OA) is a common joint disease, which characterized by degradation of articular cartilage. Evidence indicated that miR-23b-3p was upregulated in cartilage tissues patient with OA. However, the mechanism regulates occurrence and development OA remains unclear. Thus, this study aimed to investigate role progression OA.In study, qRT-PCR used measure expression tissue samples normal controls, respectively. Western blotting assay performed detect levels collagen II, aggrecan, Bax...
Low levels of inflammation-induced expression matrix metalloproteinase (MMP) play a crucial role in articular cartilage destruction osteoarthritis (OA) patients. Interferon regulatory factor-8 (IRF-8), an important member the IRF family, plays key regulating inflammation-related signaling pathway. The aim this study is to investigate physiological roles IRF-8 pathological progression OA. We found that was expressed human primary chondrocytes. Interestingly, upregulated OA In addition,...
To explore the expression characteristics of new mechanosensitive ion channel Piezo1 protein in stress models human degenerative chondrocytes.The stimulation model chondrocytes vitro was constructed. Multi-channel cell stretch loading system FX-4000T used to treat chondrocytes. According results pre-test, frequency 0.5 Hz and elongation 20% were loaded. processing time, it divided into 0 h, 2 12 24 h 48 mechanical group. The RT-PCR Western-blot test Piezo1, also Laser scanning confocal...
To compare the clinical effect of modified anterolateral and traditional acromioplasty in arthroscopic rotator cuff repair.
To evaluate the efficacy and safety of discriminative application Chinese patent medicines in female patients after percutaneous coronary intervention (PCI) due to acute syndrome (ACS).
<title>Abstract</title> <bold>Background</bold>: To explore the impact of severity tear gap caused by medial meniscus posterior root (MMPR) on extrusion and bone cartilage based magnetic resonance imaging (MRI). <bold>Methods</bold>: A retrospective analysis was conducted 153 patients with who were admitted to Jinhua Central Hospital from January 1, 2020, October 31, 2023. According size gap, they divided into mild displacement (M) group (≤4mm) extensive (W) (>4mm). The M consisted 73...
Abstract Background Risk stratification of out-of-hospital sudden cardiac death (SCD) patients after acute myocardial infarction (AMI) is crucial for timely therapeutic interventions. However, left ventricular ejection fraction (LVEF) as a traditional clinical tool has major limitations, necessitating improved risk strategies. High-throughput proteomic offers the potential to detect novel biomarkers improve assessment. Purpose To identifiy optimal circulating protein combination predicting...
Abstract Background Exaggerated inflammatory response after myocardial infarction (MI) exacerbates injury and adverse cardiac remodeling, leading to heart failure. Current management of MI involves protection antifibrotic therapy but do not target the per se. Complement factor D (CFD) is an upstream rate-limiting enzyme complement system activation, which early event post MI. We hypothesize that CFD can be important modulator inflammation-remodeling cascade MI, specific mechanism remains...
Knee osteoarthropathy is one of the most common degenerative joint diseases in elderly, total knee arthroplasty (TKA) commonly used treatment for end-stage osteoarthropathy. Negative emotions such as anxiety have been extensively documented patients.
To evaluate the effect of femoral I.D.E.A.L localization in single bundle anterior cruciate ligament reconstruction (ACLR).From January 2019 to October 2022, 122 patients with injury were treated ACLR, including 83 males and 39 females. The age ranged from 23 43 years old, an average (32.19 ±8.55) old. course disease 1 week 6 months. According different surgical schemes, divided into two groups, namely traditional group, which adopted over-the-top lateral positioning scheme, 64 patients....