A5103110263- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Advancements in Transdermal Drug Delivery
- Pelvic and Acetabular Injuries
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Skin Protection and Aging
- Hip disorders and treatments
- Amino Acid Enzymes and Metabolism
- Contact Dermatitis and Allergies
- Muscle and Compartmental Disorders
- Enhanced Recovery After Surgery
- Vascular Procedures and Complications
Fujian Medical University
2015-2025
Union Hospital
2015-2024
Tongde Hospital of Zhejiang Province
2020-2024
Immunomedics (United States)
2024
National Clinical Research Center for Digestive Diseases
2024
Dazhou Academy of Agricultural Sciences
2019-2023
First Affiliated Hospital of Xi'an Jiaotong University
2022-2023
Linzi District People's Hospital
2014-2021
Unilever (China)
2021
Tsinghua University
2009-2019
Lyophyllum decastes, also known as Luronggu in China, is a culinary edible and medicinal mushroom that was widely cultivated China recent years. In the present study, complete high-quality genome of two mating compatible L. decastes strain sequenced. The LRG-d1-1 consists 47.7 Mb 15 contigs with contig N90 2.08 14,499 predicted gene models. Phylogenetic analysis revealed exhibits close evolutionary relationship to Termitomyces Hypsizygus genus diverged from H. marmoreus ~ 45.53 Mya ago....
Abstract The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved cell metabolic processes remains largely unknown. Here, we reported that circRNA, circHIPK3, is highly expressed ESCC lines tissues. Knockdown circHIPK3 significantly restrained proliferation, colony formation, migration, invasion vitro inhibited tumor growth vivo. Mechanistically, was found to act as a ceRNA by sponging miR-637 regulate...
No consensus has been achieved for the optimal extent of left recurrent laryngeal nerve para-lymph node dissection (LRLN-LND) esophageal squamous cell carcinoma (ESCC). Surgeons follow different extents according to their experience, technical proficiency, and habits. Immunohistochemical (IHC) analysis is a feasible method detect micrometastasis (MM) lymph nodes in ESCC. We hereby explored LRLN-LND by detecting routine pathological MM-positive rates regions. retrospectively reviewed patients...
Video-assisted thoracoscopic (VATS) segmentectomy is an acceptable alternative to lobectomy for treating early-stage lung cancer. Uniportal VATS a challenging surgical procedure that has substantial technical difficulties and complications. In this study, we reviewed our experience of uniportal evaluated the feasibility learning curve procedure.Retrospective observational data 70 patients who underwent between May 2014 July 2015 were collected. Perioperative factors, such as demographic...
The present work mainly describes the preparation of acetylated mycelia polysaccharides (AMPS) from Pleurotus djamor and investigates antioxidant anti-aging effects in d-galactose-induced aging mice. optimized procedure indicates acetyl substitution degree AMPS is 0.54 ± 0.04 under conditions a reaction time 56 h, temperature 37 °C, 4 mL added acetic anhydride. vitro analysis vivo animal experiments indicate that could alleviate properties by scavenging radicals, elevating enzyme activities,...
To demonstrate the synergistic effect of 4-hexylresorcinol (4-HR) with niacinamide in boosting anti-melanogenic efficacy vitro and establish vivo safety combination a human trial.Primary epidermal melanocytes 3D pigmented skin equivalents were treated 4-HR, niacinamide, their combinations for on pigmentation. This was followed by randomized, double-blind, split-face clinical study Chinese subjects, effects tone, hyperpigmentation, fine lines wrinkles, hydration, firmness measured 12-week...
Radiotherapy benefits patients with advanced esophageal squamous cell carcinoma (ESCC) in terms of symptom relief and long-term survival. In contrast, a substantial proportion ESCC have not benefited from radiotherapy. This study aimed to establish validate an artificial neural network-based radiomics model for the pretreatment prediction radiotherapy response by using integrated data combined feasible baseline characteristics computed tomography. A total 248 who underwent CT received were...
Deregulation of microRNAs (miRs) has been observed in a variety types human cancer. Previously, miR‑30a‑5p demonstrated to exhibit suppressive role hepatocellular carcinoma (HCC). However, the underlying mechanism remains largely unclear. The present study aimed elucidate regulatory proliferation and invasion HCC cells. Quantitative reverse transcription polymerase western blotting were used examine mRNA protein expression Forkhead box A1 (FOXA1). MTT Transwell assays performed invasion....
Sarcopenia is closely associated with surgical complications in patients certain cancers. In this study we assessed the relationship between sarcopenia and postoperative oesophageal squamous cell carcinoma.We retrospectively analysed of who underwent thoracoscopic combined laparoscopic radical resection cancer. Preoperative computed tomography to evaluate skeletal muscle mass diagnose associations age, body index (BMI), lung function complications.Among 141 patients, 73 presented (sarcopenia...
Introduction Oesophageal cancer (OC) has higher morbidity and mortality rate than most other malignancies. The standard treatment for unresectable locally advanced oesophageal squamous cell carcinoma (OSCC) is concurrent chemoradiotherapy, with tumour regression observed in a proportion of patients after treatment, but prognostic improvement remains limited. Immunotherapy combination chemotherapy (CT) been shown to be efficacious as the first-line OC neoadjuvant therapy. Therefore, we...
microRNA (miR)-148a has been shown to act as an important suppressor in numerous human malignancies and is markedly downregulated hepatocellular carcinoma; however, the role of miR-148a regulation carcinoma cell invasion, well underlying mechanism, never studied. In present study, expression level was found be significantly decreased tissues HepG2 cells when compared with that normal adjacent tissues. Furthermore, a novel target found, sphingosine-1-phosphate receptor 1 (S1PR1), whose...
Circular RNAs (circRNAs) are a type of endogenous non-coding RNA with multiple binding sites that specifically bind to microRNAs (miRNAs) and serve an important role in cellular regulatory networks. Patients exhibit varying levels lymphatic metastasis clinical setting. The present study investigated the association between circRNAs esophageal squamous cell carcinoma (ESCC). tissue samples were divided into three groups, including early tumor stage associated advanced nodal (T1 group), (T2...
Post-esophagectomy airway fistula (PEAF) is a serious complication after esophageal cancer resection. At present, the clinical characteristics, treatments and prognosis of PEAF patients remain inconclusive. We aimed to investigate these problems with through multi-center retrospective cohort study.We included consecutive who underwent esophagectomy for in seven major Chinese centers from January 2010 December 2020. Based on anatomic characteristics patients, PEAFs were divided into Union...
The management of the intersegmental plane (ISP) is challenging during uniport video-assisted thoracoscopic (VATS) pulmonary segmentectomy. Staplers and electrocautery have been used extensively in ISP management. However, both them their respective drawbacks. Currently, we provided a revised technique termed as "Combined Dimensional Reduction Method" (CDR method), for managing with combined application ultrasonic scalpel staplers. study aimed to review outcomes patients who underwent VATS...
Background: The aim of this study was to determine whether a modified enhanced recovery after surgery (mERAS) protocol has positive effect on the aged patients with esophageal cancer undergoing esophagectomy.
To investigate the expression and significance of c-kit epithelial-mesenchymal transition (EMT) molecules (E-cadherin, N-cadherin, Twist, Snail) in thymic epithelial tumors (TETs).The tissue microarray technology immunohistochemistry MaxVisionTM-use kit were used to detect EMT molecular markers 150 cases paraffin sections TET analysis correlation between explore malignancy relationship clinicopathological parameters c-kit, TETs.The difference Snail, Twist) TETs subtypes was statistically...
Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and still without effective treatment method. This study aimed at evaluating combined pharmacotherapy with alendronate desferoxamine preventing glucocorticoid-induced osteonecrosis (GIOFH) efficacy medicine in regulating bone resorption regeneration.Thirty-six rats were randomly assigned to three groups: group A received (n = 12), B only C acted as control placebo 12). All induced GIOFH using methylprednisolone...
The aim of this study was to evaluate intraoperative pathological examination the left and right recurrent laryngeal nerve lymph nodes (LNs) using frozen section as a predictor cervical LN metastasis.Retrospectively collected data from 69 patients with esophageal squamous cell carcinoma who had undergone LNs sections three-field dissection in Fujian Medical University Union Hospital December 2015 April 2018, used explore relationship between metastasis determine whether cervical-field should...
Abstract Background To compare the diagnostic positive rate and complication between electromagnetic navigation bronchoscopy (ENB) technique computed tomography (CT)‐guided lung puncture for biopsy of nodules located in middle an anatomic segment. Methods Electronic medical records 114 patients who underwent nodule June 2021 2022 were retrospectively evaluated. In all patients, third rates two modalities performed this region, clinical data, rates, pathology, imaging results reviewed based...
Esophageal cancer (ESCA) is one of the most aggressive and lethal human malignant cancers. MicroRNA-1301-3p (miR-1301-3p) plays vital roles in a majority malignancies. The aim this study was to investigate role miR-1301-3p/NBL1 axis on ESCA cell invasion, migration, epithelial-mesenchymal transition (EMT) process, as well its association with prognosis patients.
Depending on the pathological stage, patients with esophageal squamous cell carcinoma (ESCC) can experience poor prognosis after surgery. This study was designed to analyze effect of various treatments in pathologic node-positive cancer who undergo radical surgery.We evaluated 210 stage IIb-IIIc (pT1-4aN + M0) had undergone esophagectomy for thoracic ESCC from January 2013 October 2015 at our institute. Surgery alone applied 65 patients, postoperative chemotherapy 112 and adjuvant...
Esophagectomy, including complete primary tumor removal and radical lymphadenectomy with or without cervical lymphadenectomy, has been accepted as a esophagectomy that remains standard treatment choice for esophageal squamous cell carcinoma (ESCC) (1,2). Studies have reported low incidences of pneumonia mortality, similar medium-term, stage-specific survival in minimally invasive (MIE), compared those reports form open (1,3).