A5101503733- Molecular Biology Techniques and Applications
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Forensic and Genetic Research
- RNA modifications and cancer
- Systemic Lupus Erythematosus Research
- RNA and protein synthesis mechanisms
- Family and Disability Support Research
- Virus-based gene therapy research
- Plant-based Medicinal Research
- Bioactive Natural Diterpenoids Research
- Monoclonal and Polyclonal Antibodies Research
- Genetic Neurodegenerative Diseases
- Platelet Disorders and Treatments
- Poxvirus research and outbreaks
- Rheumatoid Arthritis Research and Therapies
- Cell death mechanisms and regulation
- Prenatal Screening and Diagnostics
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Inflammasome and immune disorders
- Concrete and Cement Materials Research
- Artificial Immune Systems Applications
- Computational Drug Discovery Methods
- Cytokine Signaling Pathways and Interactions
Shanghai University of Traditional Chinese Medicine
2025
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
Wenzhou Medical University
2025
National Health and Family Planning Commission
2024
Xi'an Jiaotong University
2024
Henan University of Technology
2024
Zhejiang University
2024
Wuhan Polytechnic University
2024
Central South University of Forestry and Technology
2023
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by neutrophilia and NLRP3 inflammasome macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in pathogenesis AOSD, explored effect NETs on activating proinflammatory macrophages. The sera 73 AOSD patients 40 healthy controls were used to detect level cell-free DNA NET-DNA complexes. NET formation ex vivo was analyzed using immunofluorescence flow plates. activation THP-1 cells...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
Accurate diagnosis of fracture geometry and conductivity is great challenge due to the complex morphology volumetric network. In this study, a DNN (deep neural network) model was proposed predict parameters for evaluation fracturing effects. Field experience law volume conservation were incorporated as physical constraints improve prediction accuracy small amount data. A combined network adopted input both static geological dynamic The structure optimized validated through k-fold...
Monitoring body composition through Computed Tomography (CT) scans, including muscle and adipose tissue, plays a key role in the prognosis of various cancers. However, abdominal CT is impractical for patients with breast cancer (BC), making chest an essential tool postoperative surveillance. This study aims to evaluate effect subcutaneous fat tissue at 11th thoracic vertebral plane on BC by analyzing images, providing evidence nutritional rehabilitation guidance. We conducted retrospective...
Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates the regulation of pathogenesis adult-onset Still’s disease (AOSD) not investigated. In this study, we examined serum IL-37 levels and their clinical association with AOSD, explored anti-inflammatory effects on peripheral blood mononuclear cells (PBMCs) from patients AOSD. Blood samples were collected 62 AOSD 50 healthy control subjects (HC). The determined using...
Programmed cell death protein 1 (PD-1) plays an important role in immune response regulation as a co-inhibitory signal during T activation. However, there is little known about the serum autoantibody profile of PD-1 systemic lupus erythematosus (SLE), disease characterized by breakdown tolerance to self-antigens and excessive production autoantibodies. Thus, we aim investigate levels function anti-PD-1 patients with new-onset SLE. Serum IgG IgM isotypes were detected SLE (n = 90), rheumatoid...
To describe the detailed characteristics and explore potential risk factors of relapses in patients with adult-onset Still's disease (AOSD).We enrolled AOSD admitted to Department Rheumatology Immunology, Ruijin Hospital from August 2016 September 2019. Kaplan-Meier curves log rank test were used estimate cumulative relapse probability persistent remission rate before first occurrence relapse. The multivariate Cox proportional hazard method was utilized identify associated AOSD.A total 122 a...
Objective: Adult-onset Still's disease (AOSD) is a systemic disorder commonly accompanied by liver involvement. This study aims to illustrate the detailed information of abnormalities in patients with AOSD and evaluate impact on prognosis. Methods: A total number 128 hospitalized patients, who met Yamaguchi criteria Department Rheumatology Immunology, Ruijin Hospital from July 2016 August 2019 were consecutively enrolled followed up. The demographic characteristics, clinical features,...
The monoclonal gammopathies are a group of plasma-cell proliferative disorders characterized by the secretion immunoglobulin (M protein or paraprotein). Some rare cases have revealed specific affinity paraprotein as autoantibody. Here we report patient with gammopathy undetermined significance (MGUS) accompanied remarkable increase anticardiolipin antibody (aCL) and an extensively decreased coagulation factor activity, however, without any clinical signs antiphospholipid syndrome (APS)...
Abstract One key concept of Industry 4.0 is the industrial digital twin (DT)—a virtual replica physical assets, processes, and systems. DTs optimise operations, enhance productivity, facilitate innovation across various industries, including manufacturing, energy, healthcare, transportation. This paper presents a multi‐domain multi‐time scale modelling simulation platform, featuring built‐in model libraries that represent diverse physical, chemical, behavioural properties. A comprehensive...
<br><b>Background: </b> The role of Epstein–Barr virus (EBV) in inflammatory bowel disease (IBD) remains to be elucidated. aim this study was investigate the presence EBV blood and intestinal mucosa patients with IBD evaluate association between positivity IBD.<br><b>Methods: Patients IBD, hospitalized January 2015 April 2018, were enrolled. EBV-DNA load samples from each subject analyzed by quantitative real-time polymerase chain reaction. EBV-encoded small-RNA 1 (EBER-1) detected in-situ...