A5040038636- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Inflammation biomarkers and pathways
- Inflammasome and immune disorders
- Inflammatory Myopathies and Dermatomyositis
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral Infections and Immunology Research
- Otitis Media and Relapsing Polychondritis
- Kawasaki Disease and Coronary Complications
- COVID-19 Clinical Research Studies
- Family and Disability Support Research
- Blood disorders and treatments
- Eosinophilic Disorders and Syndromes
- Diabetes and associated disorders
- Gout, Hyperuricemia, Uric Acid
- SARS-CoV-2 and COVID-19 Research
- Cardiac Valve Diseases and Treatments
- Pneumonia and Respiratory Infections
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cytomegalovirus and herpesvirus research
- Celiac Disease Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Sclerosis and Related Diseases
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2020-2025
Affiliated Hospital of Nantong University
2020-2021
Yancheng First People's Hospital
2020-2021
Nantong University
2020-2021
Nanjing Medical University
2015
Jiangsu Province Hospital
2015
Guilin Medical University
2014
Xian Yang Central Hospital
2014
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Abstract Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein disorders patients, intravenous administration E is able to potentiate in mice. Through pull-down mass spectrometry, find CD36, a transmembrane glycoprotein, directly binds mediates hyperactivation human mouse platelets through p38 MAPK-NF-κB signaling pathway. Conversely,...
To evaluate the effectiveness of 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) in a Chinese cohort, and compare them with Sapporo revised criteria.
<title>Abstract</title> Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow peripheral blood from untreated primary APS patients enabled an integral “central-to-periphery” cell blueprint at single-cell resolution, wherein we observed substantial increase subsets across nearly all developmental stages. Notably, interferon...
Adult-onset Still's disease (AOSD) is an autoinflammatory disorder characterized by reactive neutrophilia and dysregulated cytokine release. Mature neutrophils exhibit increased alkaline phosphatase enzyme activity within cytoplasmic granules, particularly in response to inflammation or acute infection. However, whether neutrophil (NAP) elevated active AOSD, a hyperinflammatory state, remains unclear. We enrolled 114 patients diagnosed with 47 diffuse large B-cell lymphoma (DLBCL), 25...
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s (AOSD) an autoinflammatory characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play critical role in the pathogenesis both COVID-19 AOSD. We aimed to compare similarities differences focusing on ferritin levels between severe active A literature search was performed using databases PubMed, EMBASE, Web Science collect including IL-1β,...
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, mediated by neutrophil hyperactivation and enhanced extracellular trap (NET) formation. Type I interferons (IFNs), having primary role in initiation proinflammation responses, can induce subsequent inflammatory cytokine production. However, type IFNs AOSD unclear. Indeed, high levels IFN-α IFN-β expression are presented patients. In this investigation,...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory characterized by innate immune system activation, with high risk for macrophage activation syndrome (MAS). MAS development associated monocyte/macrophage and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by cytokine storm. Efficient early diagnosis AOSD-associated MAS requires sensitive and specific biomarker. In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD activity served as biomarker for AOSD-MAS. PTX3 levels were significantly increased in patients compared to other autoimmune diseases healthy controls. Plasma showed...
Adult-onset Still's disease (AOSD) is an autoinflammatory with multisystem involvement. Early identification of patients severe complications and those refractory to glucocorticoid crucial improve therapeutic strategy. Exaggerated neutrophil activation enhanced formation extracellular traps (NETs) in AOSD were found be closely associated etiopathogenesis. In this study, we aim investigate, our knowledge for the first clinical value circulating NETs by machine learning distinguish organ...
In December, 2019, an outbreak of the novel coronavirus (SARS-CoV-2) that causes disease 2019 (COVID-19) occurred in Wuhan, China,1Huang C Wang Y Li X et al.Clinical features patients infected with China.Lancet. 2020; 395: 497-506Summary Full Text PDF PubMed Scopus (33099) Google Scholar and soon spread all over world. Rapid accurate diagnosis SARS-CoV-2 infection is cornerstone efforts to stem its advancement. Molecular detection via RT-PCR can result falsely negative results due low viral...
Objective Adult‐onset Still’s disease (AOSD) is a severe autoinflammatory disease. Neutrophil activation with enhanced neutrophil extracellular trap (NET) formation involved in the pathogenesis of AOSD. Functional leukocyte immunoglobulin‐like receptor A3 (LIR‐A3; gene name LILRA3 ) has been reported to be associated many autoimmune diseases. We aimed investigate association susceptibility and Methods The deletion polymorphism its tagging single‐nucleotide rs103294 were genotyped 164...
To describe the detailed characteristics and explore potential risk factors of relapses in patients with adult-onset Still's disease (AOSD).We enrolled AOSD admitted to Department Rheumatology Immunology, Ruijin Hospital from August 2016 September 2019. Kaplan-Meier curves log rank test were used estimate cumulative relapse probability persistent remission rate before first occurrence relapse. The multivariate Cox proportional hazard method was utilized identify associated AOSD.A total 122 a...
Abstract Objective To explore whether inactivated coronavirus disease 2019 vaccine influences the profile of prothrombotic autoantibodies and induces thrombotic events in primary APS patients. Methods We enrolled 39 patients who received two doses severe acute respiratory syndrome 2 (SARS-CoV-2) (BBIBPCorV, Sinopharm, Beijing, China) voluntarily this prospective cohort. Prothrombotic were determined before vaccination 4 weeks after second dose vaccination. Thrombotic disorders evaluated via...
Objective: Adult-onset Still's disease (AOSD) is a systemic disorder commonly accompanied by liver involvement. This study aims to illustrate the detailed information of abnormalities in patients with AOSD and evaluate impact on prognosis. Methods: A total number 128 hospitalized patients, who met Yamaguchi criteria Department Rheumatology Immunology, Ruijin Hospital from July 2016 August 2019 were consecutively enrolled followed up. The demographic characteristics, clinical features,...
This study aimed to characterize the morbidity, hospitalization, and mortality rates among patients with adult-onset Still's disease (AOSD) affected by coronavirus 2019 (COVID-19) explore impact of COVID-19 on activity AOSD. Data clinical demographic characteristics, COVID-19-related symptoms, outcomes were retrospectively collected. Patients stratified according severity associations between risk factors analyzed using multivariate logistic regression. The AOSD flares after was described. A...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disorder. The understanding of the changes in adaptive immune cells and crosstalk between innate systems AOSD limited. This study aimed to examine peripheral cell composition inflammatory protein levels patients.
Abstract Objectives Cardiac involvement is one of the most serious complications idiopathic inflammatory myopathy (IIM) that indicates poor prognosis. However, there a lack effective biomarkers for identification cardiac and prediction prognosis in IIM. Here, we aimed to explore value different IIM patients. Methods A total 142 patients Department Rheumatology Immunology, Ruijin Hospital from July 2019 October 2022 were included this study. The clinical characteristics, laboratory tests,...
Systemic lupus erythematosus (SLE) is a complicated autoimmune disease, in which infection leading cause of death. Some SLE patients clinically presented with recurrent and refractory infections, manifested as adult-onset immunodeficiency syndrome due to the production anti-interferon-γ (anti-IFN-γ) autoantibodies. This study aimed investigate role anti-IFN-γ autoantibodies concerning severe infections patients.
To investigate the association of a coronary artery disease (CAD) risk SNP rs6903956 with asymptomatic hyperuricemia (aHU) susceptibility in Han Chinese.Two hundred and twenty one patients aHU 447 healthy controls were recruited for this study. genotyped using TaqMan probe.The overall genotype allele frequency distribution showed significant difference between cases (p<0.001 allele, respectively). AA was significantly associated (OR=8.672, 95% CI 2.811-26.753, p<0.001) our Chinese cohort....
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the persistent presence of antiphospholipid antibodies (aPL) and thrombotic or obstetric events. Given heterogeneity clinical manifestations, it likely that genetic acquired factors are involved in pathogenesis APS. The inherited polymorphisms thrombophilic gene, including methylenetetrahydrofolate reductase (MTHFR) C677T, type 1 plasminogen activator inhibitor (PAI-1) 4G/5G, factor V Leiden (FVL) G1691A,...