A5101858411- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Electrochemical sensors and biosensors
- Ubiquitin and proteasome pathways
- Adenosine and Purinergic Signaling
- T-cell and Retrovirus Studies
- DNA and Nucleic Acid Chemistry
- CAR-T cell therapy research
- Molecular Junctions and Nanostructures
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- RNA Research and Splicing
- Nanopore and Nanochannel Transport Studies
- Cancer-related Molecular Pathways
- Education and Work Dynamics
- Nuclear Receptors and Signaling
- Eosinophilic Disorders and Syndromes
Chongqing Medical University
2016-2025
Children's Hospital of Chongqing Medical University
2009-2025
Institute of Hematology & Blood Diseases Hospital
2014-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2022
Shanxi Medical University
2022
Second Hospital of Shanxi Medical University
2022
Peking Union Medical College Hospital
2021
Ministry of Education of the People's Republic of China
2013-2015
Chongqing University
2013
Stanford University
2013
Macrophages exhibit phenotypic heterogeneity under both physiological and pathological conditions. Applications targeting M2-like tumor-associated macrophages (TAMs) improve outcome in solid tumors. Considerable differences are detected between leukemia-associated (LAMs) TAMs. However, application to induce M1 characteristics heterogeneous LAMs has not been established. Here we analyzed clinical relevance of macrophage phenotypes human acute myeloid leukemia (AML), studied evolution bone...
Abstract Tumor-associated macrophages are widely studied in solid tumors. The distribution of lymph node samples was found to be associated with the prognosis lymphoma patients. However, role leukemia and their functional phenotypic characteristics hematopoietic malignancies have not been defined. In this study, we examined a Notch1-induced mouse model T cell acute lymphoblastic (T-ALL). bone marrow (BM) spleen, which proposed as BM spleen leukemia-associated (LAMs), were different during...
Abstract Background Chronic myeloid leukemia stem cells (CML-LSCs), which exhibit resistance to tyrosine kinase inhibitors (TKIs), are the leading cause of treatment failure and recurrence in chronic (CML). This highlights urgent need for novel therapies aimed at eliminating these CML-LSCs. Chimeric antigen receptor macrophages (CAR-M) not only perform phagocytosis on target but also function as antigen-presenting cells, thereby activating anti-tumor immune response.CD26 (dipeptidyl...
Tyrosine kinase inhibitors (TKIs) constitute the primary treatment for chronic myeloid leukemia (CML). However, resistance to TKIs often leads failure. Pyroptosis, a form of programmed cell death, has emerged as promising strategy in cancer therapy due its ability eliminate tumor cells while stimulating antitumor immunity. Low-dose decitabine (DAC) been shown reverse methylation-induced silencing pyroptosis-related gene gasdermin E (GSDME) some cells, offering potential new therapeutic...
Abstract The ubiquitin–proteasome system (UPS) participates in both physiological and pathological processes through the posttranslational regulation of intracellular signal transduction pathways. F-box WD-40 domain protein 11 (Fbxw11) is a component SCF (Skp1–Cul1–F-box) E3 ubiquitin ligase complex. Fbxw11 regulates various pathways, it may have roles tumorigenesis. However, role development leukemia underlying mechanisms remain largely unknown. In this study, expression was aberrantly...
Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as oncoprotein which participated in the progression various malignancies. However, its role chronic myeloid leukemia (CML) remains to be further clarified. The expression YAP CML cells determined by western blotting. Next, effects knockdown and inhibitor on were evaluated MTT assay, flow cytometry (FCM) Wright's staining. Moreover, K562 induced mice model employed investigate vivo. overexpressed cells....
Abstract Background The pathogenesis of chronic myeloid leukemia (CML) is the formation BCR/ABL protein, which encoded by bcr/abl fusion gene, possessing abnormal tyrosine kinase activity. Despite wide application inhibitors (TKIs) in CML treatment, TKIs drug resistance or intolerance limits their further usage a subset patients. Furthermore, inhibit activity oncoprotein while failing to eliminate pathologenic oncoprotein. To develop alternative strategies for treatment using therapeutic...
Interferon regulatory factor 7 (IRF7) is widely studied in inflammatory models. Its effects on malignant progression have been documented mainly from the perspective of microenvironment. However, its role leukemia has not established. Here we used MLL-AF9-induced acute myeloid (AML) mouse models with IRF7 knockout or overexpression and xenograft to explore intrinsic AML. AML-IRF7-/- mice exhibited accelerated disease intracerebral invasion AML cells. cells showed increased proliferation...
Macrophages play important roles in both physiologic and pathologic processes arise from successive waves of embryonic adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under conditions, leukemia-associated (LAM) show considerable diversities activation functional phenotype. However, their origin have not been well elucidated. Here we used wild-type CCR2-/- mice to study the monocyte-derived LAM extramedullary tissues models Notch1-induced T-cell acute...
The bcr-abl fusion gene is the pathological origin of chronic myeloid leukemia (CML) and plays a critical role in resistance imatinib. Thus, disruption-based novel therapeutic strategy may warrant exploration. In our study, we were surprised to find that characteristics sequences met design requirements zinc finger nucleases (ZFNs). We constructed ZFNs targeting with high specificity through simple modular assembly approach. Western blotting was conducted detect expression BCR-ABL...
Abstract A simple and rapid electrochemical aptamer cytosensor has been developed for direct detection of chronic myelogenous leukemia (CML) K562 cells based on a specific biotin conjugated concanavalin (bio‐ConA) probe. The cell could be specifically recognized by T2‐KK1B10 capture pre‐immobilized gold modified electrode surface. Then, bio‐ConA was added in the reaction to identify surface mannose, resulting an aptamer‐K562 cell‐bio‐ConA sandwich complex. Finally, streptavidin alkaline...
Background: Resistance to tyrosine kinase inhibitors (TKIs) in patients with chronic myeloid leukemia (CML) remains a problem clinical treatment, and the mechanism has not been fully clarified. Autophagy can protect cancer cells under chemotherapeutic stimulation. Long noncoding RNAs (lncRNAs) are critical drug resistance of CML. The role lncRNAs autophagy CML needs be further explored. Methods: Western blot immunofluorescence were used evaluate activity drug-resistant cell line K562/G01 its...
The bcr-abl fusion gene encodes BCR-ABL oncoprotein and plays a crucial role in the leukemogenesis of chronic myeloid leukemia (CML). Current therapeutic methods have limited treatment effect on CML patients with drug resistance or disease relapse. Therefore, novel strategy for is essential to be explored CRISPR RNA-guided FokI nucleases (RFNs) meet merits variable target sites specificity cleavage enabled its suitability editing CML. RFNs provide us new direction obliterate this disease....