A5007334392- Stress Responses and Cortisol
- Topic Modeling
- Neuropeptides and Animal Physiology
- Adrenal Hormones and Disorders
- Speech and dialogue systems
- Natural Language Processing Techniques
- Chemical Synthesis and Analysis
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Multimodal Machine Learning Applications
- Neuroendocrine regulation and behavior
- Telomeres, Telomerase, and Senescence
- Monoclonal and Polyclonal Antibodies Research
- Antimicrobial Peptides and Activities
- AI in Service Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Click Chemistry and Applications
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Invertebrate Immune Response Mechanisms
- Urological Disorders and Treatments
- HIV Research and Treatment
TerraMetrics (United States)
2025
Princeton University
2023-2024
Kitware (United States)
2022-2024
Alder Hey Children's NHS Foundation Trust
2024
University of Liverpool
2024
Eye Care Associates
2024
Eli Lilly (United States)
2014-2023
Meta (Israel)
2018-2022
Northwestern University
2021-2022
Meta (United States)
2021
In this work, we develop and release Llama 2, a collection of pretrained fine-tuned large language models (LLMs) ranging in scale from 7 billion to 70 parameters. Our LLMs, called 2-Chat, are optimized for dialogue use cases. outperform open-source chat on most benchmarks tested, based our human evaluations helpfulness safety, may be suitable substitute closed-source models. We provide detailed description approach fine-tuning safety improvements 2-Chat order enable the community build work...
One challenge for dialogue agents is recognizing feelings in the conversation partner and replying accordingly, a key communicative skill. While it straightforward humans to recognize acknowledge others’ conversation, this significant AI systems due paucity of suitable publicly-available datasets training evaluation. This work proposes new benchmark empathetic generation EmpatheticDialogues, novel dataset 25k conversations grounded emotional situations. Our experiments indicate that models...
Stephen Roller, Emily Dinan, Naman Goyal, Da Ju, Mary Williamson, Yinhan Liu, Jing Xu, Myle Ott, Eric Michael Smith, Y-Lan Boureau, Jason Weston. Proceedings of the 16th Conference European Chapter Association for Computational Linguistics: Main Volume. 2021.
Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production cultured adrenocortical cells. Both stimulated pituitary cells (AtT-20) release adrenocorticotropic hormone; was equipotent with a combination corticotropin-releasing arginine vasopressin, hepatocyte-stimulating at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited...
Treatment of lymphocytes with inducers interferon α (IFN-α) results in the production corticotropin (ACTH) and endorphin-like activities. The pro-opiomelanocortin-derived hormones ACTH α-, β-, γ-endorphin structurally related [Leu]- [Met]enkephalin were therefore tested for their effects on vitro antibody response mouse spleen cells. α-endorphin potent inhibitors (≥80% suppression) to T-cell-dependent antigen sheep erythrocytes at a concentration 0.5 μM. [Met]- [Leu]enkephalin moderate...
Human leukocyte interferon (hIFN-alpha) preparations contain immunologically and biologically recognizable endorphin corticotropin-like (ACTH-like) activities. The ACTH bioactivity was demonstrable only after pepsin or acid treatment. Highly purified hIFN-alpha composed of two molecular species (18,500 23,000 daltons). Endorphin activity associated with both these molecules. Pepsin treatment the 23,000-dalton but not 18,500-dalton generated activity. In acid, broke down into form (4500...
Being engaging, knowledgeable, and empathetic are all desirable general qualities in a conversational agent. Previous work has introduced tasks datasets that aim to help agents learn those isolation gauge how well they can express them. But rather than being specialized one single quality, good open-domain agent should be able seamlessly blend them into cohesive flow. In this work, we investigate several ways combine models trained towards isolated capabilities, ranging from simple model...
We present BlenderBot 3, a 175B parameter dialogue model capable of open-domain conversation with access to the internet and long-term memory, having been trained on large number user defined tasks. release both weights code, have also deployed public web page interact organic users. This technical report describes how was built (architecture, training scheme), details its deployment, including safety mechanisms. Human evaluations show superiority existing agents, predecessors (Roller et...
Anti-alpha-corticotropin [anti-ACTH alpha (1-13)](also alpha-melanotropin) and anti-gamma-endorphin antisera neutralized human leukocyte interferon activity but not fibroblast activity. Human was by anti-human lutenizing hormone (lutropin) or follicle-stimulating (follitropin) antisra. Conversely, to ACTH The neturalization of serum partially blocked ACTH. These studies show strong antigenic relatedness among interferon, ACTH, endorphins, implying that there are underlying structural...
Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment dexamethasone completely inhibited the virus-induced elevation concentration, but did not significantly alter response. Lymphocytes appear to be most likely source an adrenocorticotropin-like substance that is responsible for increased corticosterone, since spleen cells from virus-infected, control or dexamethasone-treated, showed...
An interesting pattern in the genetic code was recently observed: Codons for hydrophilic and hydrophobic amino acids on one strand of nucleic acid are complemented by codons other strand, respectively. The average tendency "uncharged" (slightly hydrophilic) is to be acids. We have postulated that this can result binding peptides encoded complementary RNA strands we presented supporting evidence. In report demonstrate specific high-affinity naturally occurring [corticotropin (ACTH)...
We have shown that corticotropin (ACTH), alpha-endorphin, and enkephalins can regulate antibody responses, which suggested a role for neuropeptides in regulatory circuit between the immune neuroendocrine systems. ACTH structurally related peptides were examined here regulation of mitogen induction lymphokine gamma-interferon (IFN gamma) C57BL/6 mouse spleen cell cultures. Synthetic ACTH1-39 porcine pituitary extract containing activity potent suppressors IFN gamma response. suppressed...
SUMMARY The stability of the infectivity Simian rotavirus, SA11, has been analysed and compared to reovirus type 1. SA11 was stable freeze-thawing, sonication, incubation at 25 °C overnight or 37 for 1 h treatment with acid, ether, chloroform Genetron. In contrast reovirus, more rapidly inactivated by heating 50 °C. above pH 10.0 in 2 m-MgCl2, but stabilized m-MgSO4; enhanced MgCl2. Both were freezing These results show that rotaviruses reoviruses can be distinguished their patterns...
Evidence supporting the concept that parasitic trematode Schistosoma mansoni may escape immune reactions from its vertebrate (man) or invertebrate (the freshwater snail Biomphalaria glabrata) hosts by using signal molecules it has in common with these was obtained following experiments. The presence of immunoactive proopiomelanocortin (POMC)-derived peptides [corticotropin (ACTH), beta-endorphin] in, and their release from, S. demonstrated. Coincubation adult worms human polymorphonuclear...
Interferon-alpha inducers were previously shown to cause human lymphocyte production of a corticotropin (ACTH)-like peptide. Thyrotropin (TSH) was not produced under these conditions. In contrast, this report shows that T-cell mitogen (staphylococcal enterotoxin A), which does induce the ACTH-like peptide, caused an immunoreactive (ir) TSH. Lymphocyte synthesis ir TSH first detectable at 24 hr, peaked 48 and thereafter declined. NaDodSO4/polyacrylamide gel electrophoresis intrinsically...