A5043581345- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Acute Lymphoblastic Leukemia research
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Nigella sativa pharmacological applications
- Hormonal and reproductive studies
- Vitamin C and Antioxidants Research
- Laser Applications in Dentistry and Medicine
- Reproductive Biology and Fertility
- Paraoxonase enzyme and polymorphisms
- Estrogen and related hormone effects
- Pharmacological Effects of Natural Compounds
- Childhood Cancer Survivors' Quality of Life
- HER2/EGFR in Cancer Research
- Garlic and Onion Studies
- Reproductive System and Pregnancy
- Liver physiology and pathology
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- NF-κB Signaling Pathways
- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
Beni-Suef University
2016-2025
Modern University for Information and Technology
2024
Ain Shams University
2024
Ajman University
2015
Despite its broad applications, cisplatin affords considerable nephro- and hepatotoxicity through triggering inflammatory oxidative stress cascades. The aim of the current investigation was to study possible protective effects tangeretin on cisplatin-induced hepatotoxicity. impact cisplatin-evoked hepatic dysfunction histopathologic changes along with stress, apoptotic biomarkers were investigated compared silymarin. Tangeretin pre-treatment significantly improved liver function tests (ALT...
Berberine (BBR) is a natural compound of plant origin belonging to isoquinoline type alkaloid. Methotrexate (MTX) an anti-metabolite used widely for variety tumors and autoimmune conditions. Clinical uses MTX were severely limited by its concomitant renal intoxication. The current study was designed investigate the efficacy BBR against MTX-induced nephrotoxicity exploring underlying molecular mechanisms through examining Keap1/Nrf2, NF-κB/P38MAPK Bax/Bcl2/caspase-3 pathways. Adults male rats...
Abstract Background Irinotecan is a chemotherapeutic agent used to treat variety of tumors, including colorectal cancer (CRC). In the intestine, it transformed into SN-38 by gut microbial enzymes, which responsible for its toxicity during excretion. Objective Our study highlights impact on microbiota composition and role probiotics in limiting Irinotecan-associated diarrhea suppressing bacterial β-glucuronidase enzymes. Material methods To investigate effect composition, we applied 16S rRNA...
Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs), such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and anti-inflammatory properties, clinically used for treating some vascular disorders. The current work targeted exploring the protective properties diosmin to counteract DEX-induced in vivo. Rats were administered DEX (7 mg/kg) once weekly 5 weeks, second week, vehicle or (50 100 mg/kg/day) next four weeks. Femur bone...
Abstract Ulcerative colitis is an autoimmune inflammatory disorder with a negative impact on the life quality of patients. Cinnamaldehyde and hesperetin were chosen due to their antioxidants anti‐inflammatory effects. This study explored protective effects cinnamaldehyde (40 90 mg/kg, po) (50 100 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced ulcerative in rats. significantly improved macroscopic histopathological examinations significant reduction myeloperoxidase intracellular adhesion...
Rebamipide is a quinolone derivative that has been commonly used for the treatment of gastric and duodenal ulcers. However, molecular mechanisms rebamipide against acetic acid-evoked colitis have not adequately examined. Hence, current study aimed to investigate ameliorative effect in rat model ulcerative linked pertaining SIRT1/FoxO3a/Nrf2 PI3K/AKT pathways. Herein, was induced by intrarectal administration 3% acid solution saline (v/v) while administered oral gavage (100 mg/kg/day) seven...
Hepatocellular carcinoma (HCC) represents around 85% of all known types liver cancers and is estimated to be the fifth most common cause cancer-related death worldwide. The current study assessed preventive efficacy isatin on diethylnitrosamine (DENA)/2-acetylaminofluorene (2-AAF)-induced hepatocarcinogenesis in male Wistar rats investigated underlying cellular molecular mechanisms. HCC was initiated by intraperitoneal injection DENA (150 mg/kg/week) for two weeks, followed oral 2-AAF (20...