A5039967283- Laser Applications in Dentistry and Medicine
- Synthesis and Biological Evaluation
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Endoplasmic Reticulum Stress and Disease
- Liver Disease and Transplantation
- Pomegranate: compositions and health benefits
- FOXO transcription factor regulation
- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
- Radiation Effects and Dosimetry
- Antimicrobial Resistance in Staphylococcus
- Biomarkers in Disease Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Metal complexes synthesis and properties
- Cardiac Ischemia and Reperfusion
- Drug-Induced Hepatotoxicity and Protection
- Anesthesia and Neurotoxicity Research
- Heat shock proteins research
- Bone Metabolism and Diseases
Beni-Suef University
2014-2025
University of Manchester
2022-2025
Secondary osteoporosis is commonly caused by long-term intake of glucocorticoids (GCs), such as dexamethasone (DEX). Diosmin, a natural substance with potent antioxidant and anti-inflammatory properties, clinically used for treating some vascular disorders. The current work targeted exploring the protective properties diosmin to counteract DEX-induced in vivo. Rats were administered DEX (7 mg/kg) once weekly 5 weeks, second week, vehicle or (50 100 mg/kg/day) next four weeks. Femur bone...
A set of meta-substituted 3-arylisoquinolinones have been identified that show substantial cytotoxicity in breast, liver, lung and colon cancer cell lines; these are up to 700-fold more active than the corresponding para analogues. These compounds were initially proposed as inhibitors N-ribosyl dihydronicotinamide (NRH): quinone oxidoreductase 2 (NQO2) but found be inactive against enzyme. Instead, COMPARE analysis suggested 6-fluoro-3-(meta-fluorophenyl)isoquinolin-1(2H)-one (4) could mimic...
Multidrug resistance (MDR) pathogens are usually associated with higher morbidity and mortality rates. Flavonoids good candidates for the development of new potential antimicrobials. This research investigated whether luteolin 4'-neohesperidoside (L4N) has antibacterial synergistic activities against four antibiotic-resistant pathogens: methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, fosA-positive shiga toxin producing Escherichia coli serogroup O111 (STEC O111),...
Hyperlipidemia (HL) with subsequent coronary atherosclerosis is the major trigger of ischemia and hence, myocardial infarction (MI) occurs. The present study aimed to elucidate effects pretreatment rosuvastatin ellagic acid, as well their combination on isoproterenol-induced MI in hyperlipidemic rats. Adult rats were fed a cholesterol-rich diet for seven weeks received (10 mg/kg) and/or acid (30 by oral gavage daily starting from fifth week then subcutaneously injected two doses 24-h apart...