A5003549863- Epigenetics and DNA Methylation
- Immune cells in cancer
- Chemotherapy-induced organ toxicity mitigation
- Bioactive Compounds and Antitumor Agents
- Bioactive Natural Diterpenoids Research
- Cancer therapeutics and mechanisms
- Nematode management and characterization studies
- Carcinogens and Genotoxicity Assessment
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Sperm and Testicular Function
- Genomics, phytochemicals, and oxidative stress
- Natural Compounds in Disease Treatment
- Microtubule and mitosis dynamics
- PARP inhibition in cancer therapy
- Protein Kinase Regulation and GTPase Signaling
- Electron Spin Resonance Studies
- Plant Growth Enhancement Techniques
- Plant Disease Management Techniques
- Ferroptosis and cancer prognosis
- Ethnobotanical and Medicinal Plants Studies
- Ubiquitin and proteasome pathways
- Mast cells and histamine
- Seaweed-derived Bioactive Compounds
- Plant Growth and Agriculture Techniques
Najran University
2025
Al-Azhar University
2015-2024
Centre National de la Recherche Scientifique
2024
National Research Centre
2019-2023
Minia University
2009-2022
Al-Azhar University
2013-2020
Ain Shams University
1977-2020
King Saud University
2003-2014
Menoufia University
1986
Centrum für Integrierte Onkologie
1986
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic cancer. Emerging evidence suggests that tumor-associated macrophages (TAMs) play an immunosuppressive role in tumor microenvironment and promote growth, angiogenesis, metastasis Therefore, targeting TAMs patients with cancer appealing strategy; however, all trials to date have failed. To improve efficacy of this approach, we sought elucidate underlying mechanisms We found developmental transcription factor GATA3 was...
Few published studies have reported the use of crude camel milk in treatment stomach infections, tuberculosis and cancer. Yet, little research was conducted on effect apoptosis oxidative stress associated with human The present study investigated underlying mechanisms proliferation cancer cells using an vitro model hepatoma (HepG2) breast (MCF7) cells. Our results showed that milk, but not bovine significantly inhibited HepG2 MCF7 through activation caspase-3 mRNA activity levels, induction...
Clinical use of doxorubicin (DOX) is limited by its cardiotoxic side effects. Recent studies established that metformin (MET), an oral antidiabetic drug, possesses antioxidant activity. However, whether it can protect against DOX-induced energy starvation and mitochondrial damage has not been reported. Our results, in a rat model cardiotoxicity, show DOX treatment significantly increased serum levels LDH CK-MB, indicators cardiac injury, induced expression hypertrophic gene markers. also...
The testis is an immunologically privileged organ. Sertoli cells can form a blood‐testis barrier and protect sperm from self‐immune system attacks. Spermatogenesis may be inhibited by severe illness, bacterial infections chronic inflammatory diseases but the mechanism(s) poorly understood. Our objective to help in understanding such develop protective agents against temporary or permanent testicular dysfunction. Lipopolysaccaride (LPS) used as model of animal sepsis while L‐carnitine (LCR)...
Abstract Rheumatoid arthritis (RA) is one of the major autoimmune diseases with a global prevalence. Despite significant research into this disease, no drugs acceptable safety profiles are yet available for its treatment. We investigated possible anti-arthritic effects 4-methylhistamine (4-MeH) histamine 4 receptor (H4R) agonist and JNJ77777120 (JNJ) H4R antagonist to explore role in mouse model collagen antibody-induced (CAIA). Arthritis was induced via intravenous (tail vein) injection...
It has been recently postulated from our laboratory that Arabic gum (AG) offers a protective effect in the kidney of rats against nephrotoxicity induced by gentamicin via inhibiting lipid peroxidation. also shown powerful antioxidant through scavenging superoxide anions. In this study we utilized rat model cisplatin (CP)-induced to determine its peak time following (1, 2, 5, and 7 days) single CP (7.5 mg/kg, i.p.) injection. Also, possible cotreatment with AG g/kg/day p.o.) on CP-induced was...
Cylophosphamide (CYCL) is a strong anticancer and immunosuppressive agent but its urotoxicity presents one of the major toxic effects that limit wide usage particularly in high dose regimens. Therefore, this study aimed to investigate Acacia Senegal gum exudate, Gum Arabic (GA), for possible role as natural, nontoxic against CYCL‐induced urotoxicity. Male Swiss albino rats were exposed CYCL (150 mg/kg BW, once i.p) with or without GA oral supplementation (7.5 g/kg/day 6 days) through...
The intention of the present study was to answer question whether catalytic topoisomerase-II inhibitor, dexrazoxane, can be used as a modulator teniposide-induced DNA damage and programmed cell death (apoptosis) in bone marrow cells vivo. alkaline single gel electrophoresis, scoring chromosomal aberrations, micronuclei mitotic activity were undertaken current markers damage. Apoptosis analysed by occurrence hypodiploid peak caspase-3 activity. Oxidative stress marker such intracellular...
Traditional antibiotic therapy of staphylococcal osteomyelitis by a single drug or combination is ineffective in producing complete sterilization infected bones. The aim this study was to develop non-traditional delivery system antibiotics for treatment chronic experimental osteomyelitis.In the current work, ciprofloxacin and vancomycin were encapsulated cationic, anionic neutral liposomal formulation. For prolonged circulation serum, dispersions (<100 nm diameter) sonicated different times...