A5023571726- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Chemotherapy-induced organ toxicity mitigation
- Natural Antidiabetic Agents Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Acid Research Studies
- Rheumatoid Arthritis Research and Therapies
- Pharmacology and Obesity Treatment
- Protease and Inhibitor Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Diabetes and associated disorders
- Inflammatory mediators and NSAID effects
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Cytokine Signaling Pathways and Interactions
- Phytochemicals and Antioxidant Activities
- Drug-Induced Hepatotoxicity and Protection
Suez Canal University
2016-2025
Scientific Research Institute of Biochemistry
2021
King Abdulaziz University
2021
GTx (United States)
2012
Kobe University
2009
Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms GST gene family on risk developing type-2 diabetes mellitus and glycemic control. also investigated effects smoking combined with these risk. enrolled 100 patients healthy controls matched for age, gender origin, from Sinai area Egypt. Fasting serum glucose, HbA(1c) lipid profiles were determined. Two identified by multiplex PCR within genes: GSTM1 GSTT1. The proportion...
<b>Objective:</b> To evaluate the neuroprotective effect of nootropic drugs, piracetam (PIR) and vinpocetine (VIN), in rotenone-induced Parkinsonism rats.<br><b>Materials Methods:</b> Sixty male rats were divided into 6 groups 10 each. The administered vehicle, control (rotenone, 1.5 mg/kg/48 h/6 doses, s.c.), PIR (100 200 mg/kg/day, p.o.) VIN (3 p.o.). motor performance was evaluated by open field pole test. Striatal dopamine level, malondialdehyde (MDA), reduced glutathione (GSH) tumor...
Abstract Background Gallstones are abnormal lumps in the gallbladder or biliary tract due impaired cholesterol, bilirubin, bile salt metabolism. The Adenosine triphosphate binding cassette transporter genes G5 and G8 (ABCG5, ABCG8) two half transporters which work together as a heterodimer to regulate cholesterol levels bile, any alterations their function can contribute gallstone formation. primary objective of this study was evaluate association between three specific polymorphisms—ABCG5...
Introduction: Type 2 diabetes mellitus (T2DM) is associated with increased production of reactive oxygen species and a reduction in antioxidant defenses leading to oxidative stress.Glutathione S-transferases (GSTs) modulate stress.The present cross-sectional study was aimed at investigating the association between GSTP1 gene polymorphism T2DM clarify their effect on glycemic control parameters.Material methods: From Egyptian population, we enrolled 112 patients 188 healthy controls matched...
Plicosepalus acacia (Fam. Loranthaceae) has been reported to possess hypoglycemic, antioxidant, antimicrobial, and anti-inflammatory effects. Liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) analysis revealed the presence of a high content polyphenolic compounds that are attributed therapeutic effects crude extract. In addition, methyl gallate quercetin were detected as major phytomedicinal agents at concentrations 1.7% 0.062 g%, respectively, using high-performance...
In recent times, the counterfeiting of pharmaceuticals has been considered a serious trouble especially in developing countries that acquire poor inspection programs. Sildenafil, vardenafil and tadalafil (phosphodiesterase type 5 inhibitors) products have gained wide popularity treating sexual disorders, for which they are subjected to counterfeiting. For this purpose, simple, rapid, novel HPLC method with ultraviolet detection simply developed simultaneous determination vardenafil,...
Aim: The metabolic syndrome is a complex of interrelated risk factors for cardiovascular disease and diabetes. adipokines, chemerin vaspin, are known to have regulatory roles. This study aimed assess the relation rs17173608 vaspin rs2236242 polymorphisms with its related phenotypes in Egyptian women. Subjects methods: included 100 healthy female subjects patients. component traits were determined genotypes assessed using tetra amplification refractory mutation system polymerase chain...
Our study aims at determining whether genetic polymorphisms of catalase (CAT 1167C/T) and superoxide dismutase (SOD +35 A/C) could be associated with type 2 diabetes mellitus (T2DM). The was conducted on 105 Egyptian patients T2DM 115 control subjects. Genotypes were done by polymerase chain reaction-restriction fragment length polymorphism methods. Homeostatic model assessment insulin resistance (HOMA-IR), CAT SOD activities, glycated hemoglobin, lipid profiles assessed. activities...