A5076822722- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Plant Pathogens and Fungal Diseases
- Sesquiterpenes and Asteraceae Studies
- Synthetic Organic Chemistry Methods
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Marine Sponges and Natural Products
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Cancer Treatment and Pharmacology
- Plant Toxicity and Pharmacological Properties
- Phytochemicals and Antioxidant Activities
- Natural Compound Pharmacology Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Mycorrhizal Fungi and Plant Interactions
- Carbohydrate Chemistry and Synthesis
- Synthesis of Organic Compounds
- Alkaloids: synthesis and pharmacology
Lund University
2014-2023
Chemical Synthesis Lab
2003-2019
Northwest A&F University
2009
Carleton University
2009
Biotechnology Research Institute
2009
Autonomous University of Campeche
2009
Higher University of San Andrés
2009
Getinge (Sweden)
2008
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2001-2007
Institut für Biotechnologie und Wirkstoff-Forschung
2000-2007
Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency spicy aroma. Many health benefits have been ascribed extracts, including hypotensive vasorelaxant activities. However, molecular mechanisms underlying these effects remain unknown. Intriguingly, DADS share structural similarities with allyl isothiocyanate, pungent ingredient in wasabi other mustard induces pain inflammation by...
The endogenous C18 N-acylethanolamines (NAEs) N-linolenoylethanolamine (18:3 NAE), N-linoleoylethanolamine (18:2 N-oleoylethanolamine (18:1 and N-stearoylethanolamine (18:0 NAE) are structurally related to the endocannabinoid anandamide (20:4 but these lipids poor ligands at cannabinoid CB1 receptors. Anandamide is also an activator of transient receptor potential (TRP) vanilloid 1 (TRPV1) on primary sensory neurons. Here we show that NAEs present in rat ganglia vascular tissue. With...
An acetone extract of Helichrysum italicum ssp. microphyllum afforded the phloroglucinol α-pyrone arzanol (1a) as a potent NF-κB inhibitor. Arzanol is identical with homoarenol (2a), whose structure should be revised. The phloroglucinol-type and 1,2,4-trihydroxyphenyl-type base-induced fragmentation product could reconciled in light retro-Fries-type that triggers change hydroxylation pattern aromatic moiety. On basis these findings, arenol, major constituent clinically useful antibiotic...
Significance Prostate cancer is the most common malignancy and third leading cancer-related cause of death among men Western world. Treatment options at advanced stages disease are scarce, better therapies in urgent need. In our study, we show that clinically relevant lipid kinase phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) plays an important role cell invasion survival by regulating PI3K/AKT/androgen receptor pathways. Elevated levels PIP5K1α contribute to proliferation, survival,...
The affinities for the benzodiazepine binding site of GABAA receptor 21 flavonoids have been studied using [3H]flumazenil to rat cortical membranes in vitro. We show that with high affinity vitro spanning whole efficacy range from agonists (1q) inverse (1l) can be synthesized. properties successfully rationalized terms a comprehensive pharmacophore model recently developed by Cook and co-workers (Drug Des. Dev. 1995, 12, 193−248), supporting validity this model. However, contrast requirement...
Screening of nematode-trapping fungi for antimicrobial and nematicidal activities gave three new metabolites from cultures five Arthrobotrys strains. The compounds exhibited no towards Caenorhabditis elegans Meloidogyne incognita. From trap-forming submerged conoides, linoleic acid was isolated as a principle. Its production increased with the number traps formed in both oligospora conoides. Nematoctonus robustus concurrens produced pleurotin, dihydropleurotinic acid, leucopleurotin,...
To further develop and evaluate a pharmacophore model previously proposed by Cook co-workers (Drug Des. Discovery 1995, 12, 193−248) for ligands binding to the benzodiazepine site of GABAA receptor, 40 new flavone derivatives have been synthesized their affinities determined. Two regions steric repulsive interactions between ligand receptor characterized, region in vicinity 6- 3'-substituents has mapped out. 2'-Hydroxy substitution is shown give significant increase affinity, which...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Sesquiterpenes of Lactarius vellereus and Their Role in a Proposed Chemical Defense SystemOlov Sterner, Rolf Bergman, Jan Kihlberg, Börje WickbergCite this: J. Nat. Prod. 1985, 48, 2, 279–288Publication Date (Print):March 1, 1985Publication History Published online1 July 2004Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/np50038a013https://doi.org/10.1021/np50038a013research-articleACS PublicationsRequest reuse...
Galiellalactone is a potent and specific inhibitor of STAT3 signaling which has been shown to possess growth inhibitory effects on prostate cancer cells expressing active STAT3. In this study we aimed investigate the effect galiellalactone stem cell-like cells. We explored expression aldehyde dehydrogenase (ALDH) as marker for in different human cell lines ALDH (ALDH+) ALDH+ subpopulations were detected isolated from DU145 long-term IL-6 stimulated LNCaP using ALDEFLUOR® assay flow...
Twenty unsaturated sesquiterpene dialdehydes were tested for antimicrobial, algaecidal, cytotoxic, and mutagenic activity. In addition to the known antifungal activity, polygodial (1) also exhibited antibacterial cytotoxic activity; epipolygodial (2) was slightly less active. The most active compounds were: isovelleral (7), isoisovelleral (8), velleral (20), methylmarasmate (6). With exception of they activity in Salmonella/ microsome assay. Derivatization polar usually increased...
Abstract BACKGROUND Signal transducer and activator of transcription 3 (Stat3) is constitutively active (phosphorylated) in several forms cancer, including prostate cancer (PCa). Stat3 signaling may be an interesting target for therapy since inhibition this pathway mediates growth apoptosis these cells. In study we investigated the vitro vivo effects fungal metabolite galiellalactone, a direct inhibitor Stat3, on PCa METHODS The human cell lines DU145, PC‐3, LNCaP were used. Nude mice with...
The dimeric nonprenylated acylphloroglucinol semimyrtucommulone (6) was obtained from the leaves of myrtle (Myrtus communis) as a 2:1 mixture two rotamers. known trimeric phloroglucinol myrtucommulone A (1) also isolated and characterized spectroscopically silylated cyclized derivative (5). Myrtucommulone showed significant antibacterial activity against multidrug-resistant (MDR) clinically relevant bacteria, while less active.