A5010147041- Nigella sativa pharmacological applications
- Animal Nutrition and Physiology
- Bioactive Compounds and Antitumor Agents
- Moringa oleifera research and applications
- Chemotherapy-induced organ toxicity mitigation
- Natural Antidiabetic Agents Studies
- Antioxidants, Aging, Portulaca oleracea
- Biochemical effects in animals
- Pharmacological Effects of Natural Compounds
- Date Palm Research Studies
- Nanoparticles: synthesis and applications
- Aquaculture Nutrition and Growth
- Ginger and Zingiberaceae research
- Chemotherapy-induced cardiotoxicity and mitigation
- Drug-Induced Hepatotoxicity and Protection
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Retinoids in leukemia and cellular processes
- Piperaceae Chemical and Biological Studies
- Medicinal Plants and Bioactive Compounds
- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Environmental Toxicology and Ecotoxicology
- Computational Drug Discovery Methods
- Adipose Tissue and Metabolism
Damanhour University
2016-2025
Southwest Medical University
2024-2025
King Abdulaziz University
2021
Kanazawa University
2018
Alexandria University
2010
Antioxidants have valuable effects on the process of spermatogenesis, particularly with diabetes mellitus (DM). Therefore, present study investigated impact and intracellular mechanisms by which thymoquinone (TQ) works against diabetes-induced testicular deteriorations in rats. Wistar male rats (n = 60) were randomly allocated into four groups; Control, Diabetic (streptozotocin (STZ)-treated where was induced intraperitoneal injection STZ, 65 mg/kg), + TQ (diabetic treated (50 mg/kg) orally...
Oxidative stress results from the imbalance between reactive oxygen species (ROS) production and antioxidant defence is primarily involved in aging. The current study investigated activity of rutin aging rats induced by D-galactose (D-gal) for 42 days. Rutin was orally used at doses 50 100 mg kg-1 daily. Results showed that D-gal oxidative alterations brain liver recognized via upregulation markers. In contrast, ameliorated enhancing markers such as superoxide dismutase-1, glutathione...
Abstract Background Traditional herbal medicine has been used for centuries to cure many pathological disorders, including cancer. Thymoquinone (TQ) and piperine (PIP) are major bioactive constituents of the black seed ( Nigella sativa ) pepper Piper nigrum) , respectively. The current study aimed explore potential chemo-modulatory effects, mechanisms action, molecular targets, binding interactions after TQ PIP treatments their combination with sorafenib (SOR) against human triple-negative...
Sorafenib (Sor) is the only approved multikinase inhibitor indicated for treatment of HCC. Previous studies have shown that amygdalin (Amy) possesses anticancer activities against several cancer cell lines; we suggested these compounds might disrupt AMPK/mTOR and BCL-2. Therefore, current study used integrated in vitro silico approaches to figure out Amy Sor's possible synergistic activity targeting BCL-2 anti-angiogenesis apoptosis death HepG2 cells.Notably, demonstrated exceptional...
Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This study examined the protecting influence of thymoquinone (TQ) on diabetes-caused cardiac complications. The intracellular means by which TQ works against myopathy in rats not completely understood. In this study, Wistar male (n = 60) were assigned into four groups: control, (diabetes induced IP infusion streptozotocin, 65 mg/kg), + (diabetic given (50 mg/kg) administered once per day stomach gavage), and...
Medicinal plants are sources of novel drug discovery targets. Costus speciosus is an important medicinal plant widely used for the treatment various ailments. The has multiple active ingredients and been found to possess many pharmacological activities such as antioxidant, anticancer, anti‑inflammatory, antidiabetic, hypolipidemic, hepatoprotective, steroidogenic, adaptogenic, antimicrobial effects. This review gives account unique studies on C. phytochemical, toxicological, traditional uses...
Aging is an oxidative stress-associated process that progresses with age. Our aim to delay or attenuate these alterations and keep individuals healthy as they age using natural compounds supplementation. Therefore, we conducted the present study investigate protective potentials of quercetin against D-galactose (D-gal)-associated were induced experimentally in male Wistar rats. Forty-five rats randomly allocated into five groups nine each. The a control group was reared on basal diet...
Quercetin was fed to groups of broiler chickens at concentrations 200, 400, and 800 ppm, a control group supplemented with basal diet. Results revealed that quercetin dietary supplementation numerically improved the growth performance traits significantly increased (p < 0.05) European production efficiency factor (EPEF) in 200 ppm group. The total coliforms Clostridium perfringens were decreased quercetin-supplemented groups. Conversely, Lactobacillus counts 0.05), due improvement gut...
Hepatocellular carcinoma (HCC) is a serious and potentially fatal form of cancer associated with liver damage. New anticancer drugs are increasingly needed due to the increasing number cases every year. In this study, diarylheptanoids (DAH) from Alpinia officinarum were examined for their antitumor activity against DAB-induced HCC in mice, as well ability reduce Assays cytotoxicity conducted using MTT. The Swiss albino male mice given DAH sorafenib (SOR) either single treatments or...
Supplementation of exogenous enzymes in chickens has been widely practiced, yet mechanisms responsible are not fully delineated. To investigate the effects dietary lysozyme on growth performance and immunity broiler chickens, a total 120 one-day-old Ross 308 chicks were randomly allocated into four groups, each having three replicates (30 birds/group). The fed starter (1–21 d) grower (22–35 diets supplemented with 0 (control), 70 (LYZ70), 90 (LYZ90) (LYZ120) g 10%® per ton basal diet for...
Diminishing the cost of broiler chicken diet is a critical issue in poultry industry. Numerous studies were performed to achieve this pivotal objective by supplementation with alternative feed additives. In current study, low-energy rations supplemented different commercial multienzyme formulations minimize cost, and increase digestibility absorption digested macronutrients. Cobb Avian 48 chicks (mixed sex, 1-d-old, n = 3120) randomly allocated into six groups, each group was subdivided four...
Cellular senescence is a process of physiological growth arrest that can be induced by intrinsic or extrinsic stress signals. Some cancer therapies are associated with cells typical cell cycle arrest. Doxorubicin (Dox) induces p53-dependent pathway and telomere dysfunction numerous cancers. However, cellular suppression in proliferation activity, these will remain metabolically active play an important role tumor relapse development drug resistance. In the current study, we investigated...
Cancer is a multifactorial disorder that induces mortality worldwide, and the colorectal type third most common cancer globally. Resveratrol (RSV) natural compound with an effective anticancer effect, especially against cancer, therefore numerous studies recommended its use in prevention treatment. The current study investigated effect of either RSV or nanoformulation (NP-RSV) on growth vascularity xenograft orthotopic mice models colon (COLO205-luc). Both NP-RSV induced significant...
Aging represents the accumulation of progressive changes in a human being over time and can cover physical, psychological, social changes. It is an oxidative stress-associated process that progresses with age. The antioxidant activity either eugenol (EU) or carvacrol (CAR) for aging rats induced by D-gal 42 days was investigated current study using 10 20 mg EU/kg/day/orally, while CAR supplemented 40 80 /kg/day/orally. Biochemical, mRNA expression, histopathological assessments brain samples...
The theory of aging is primarily concerned with oxidative stress caused by an imbalance in reactive oxygen species generation and cellular antioxidants. To alleviate the stress, we investigated protective effect diosgenin (DSG) for D-galactose (D-gal) using 20 40 mg DSG/kg/day/orally 42 days. findings showed that D-gal brain liver injuries upregulating markers. counteract D-gal, DSG upregulated glutathione peroxidase-1, superoxide dismutase-1, S-transferase-α. also diminished expression