A5010854408- Piperaceae Chemical and Biological Studies
- Computational Drug Discovery Methods
- Nigella sativa pharmacological applications
- Cholinesterase and Neurodegenerative Diseases
- Dermatological and COVID-19 studies
- COVID-19 Clinical Research Studies
- Dental materials and restorations
- Synthesis and biological activity
- Endodontics and Root Canal Treatments
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- Bone and Joint Diseases
- Berberine and alkaloids research
- Dental Anxiety and Anesthesia Techniques
- Ginseng Biological Effects and Applications
Kafrelsheikh University
2016-2024
Abstract Background Traditional herbal medicine has been used for centuries to cure many pathological disorders, including cancer. Thymoquinone (TQ) and piperine (PIP) are major bioactive constituents of the black seed ( Nigella sativa ) pepper Piper nigrum) , respectively. The current study aimed explore potential chemo-modulatory effects, mechanisms action, molecular targets, binding interactions after TQ PIP treatments their combination with sorafenib (SOR) against human triple-negative...
Avascular necrosis (AVN) is a debilitating condition characterized by bone tissue death due to inadequate blood supply, leading joint dysfunction and collapse. This study investigates the potential association between AVN COVID-19, focusing on genetic factors such as NOS3 polymorphisms. A total of 180 individuals were included, comprising 120 COVID-19 patients 60 healthy controls. Clinical, haematological, biochemical, parameters assessed. Results revealed significant differences in...
This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine used as protective/curative compound resistance. Results revealed that feeding rats HFD weeks developed features (IR) syndrome. These presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with LDL-cholesterol decreased...
Background: Breast cancer is the most common diagnosed in women. Worldwide, it second cause of cancer-related mortality among Plants have been primary sources natural product drug discovery, over 60% current anticancer drugs were derived from sources. Piperine (PIP) a major bioactive constituent black pepper (Piper nigrum). Aim: We assessed cytotoxicity PIP and anti-hepatocellular carcinoma Sorafenib (SOR) against human triple negative breast MDA-MB-321 cell line. Furthermore, we...