A5050441744- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Chronic Kidney Disease and Diabetes
- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- TGF-β signaling in diseases
- Tryptophan and brain disorders
- Osteoarthritis Treatment and Mechanisms
- Carcinogens and Genotoxicity Assessment
- Olfactory and Sensory Function Studies
- NF-κB Signaling Pathways
- Hypothalamic control of reproductive hormones
- Natural Antidiabetic Agents Studies
- Chemotherapy-induced organ toxicity mitigation
- Cardiac Ischemia and Reperfusion
- Drug-Induced Hepatotoxicity and Protection
- Antioxidant Activity and Oxidative Stress
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Acute Kidney Injury Research
- Traditional and Medicinal Uses of Annonaceae
- Diet, Metabolism, and Disease
- Bioactive Compounds in Plants
- Neuroscience and Neuropharmacology Research
Kafrelsheikh University
2020-2024
Monosodium glutamate (MSG) is a widely used food additive, and there trepidation that MSG plays critical role in multiple hepatic disorders. This study was planned to investigate Graviola extract (GE) effects on cellular alterations induced by MSG. Fifty Wistar rats were randomly allocated into five groups: control (received normal saline), 200 mg/kg body weight), 2.4 gm MSG/kg, 15% of Lethal dose (LD50) MSG), + monosodium (MSG GE; received GE, mg/kg/day gm/kg weight (BW) for the next four...
Acute kidney injury (AKI) is a sudden insult of the that happens within short period time, which associated with poor prognosis in diabetic patients myocardial infarction (MI). Subclinical AKI condition tubular damage biomarkers [Neutrophil gelatinase-associated lipocalin (NGAL) and molecule-1(KIM-1)] are positive even absence elevated serum creatinine. Recent studies reported SGLT-2 inhibitors could protect against subclinical by elevating level β-Hydroxybutyric acid (βOHB). This study aims...
Background: Several previous studies explored the toxic effect of high-fat diet (HFD) and high-fructose (HFrD), however little is known regarding their differential detrimental effects on kidney.Aim: This study was conducted to compare biochemical, histological, molecular changes in kidney induced by consumption HFD HFrD for 4 8 weeks.Materials Methods: Thirty-five rats were randomly divided into five groups (n = 7/group): control, HFD1 (fed 4w), HFrD1 (for HFD2 8w), HFrD2 8w).The studied...
Diet rich in purines may increase the serum level of uric acid causing hyperuricemia, contributing to learning and memory impairments. Ascorbic has a potent antioxidant potential. The hippocampus is pivotal component human brains other vertebrates that plays crucial roles consolidation information spatial memory. Our study was mainly designated examine potential palliative role ascorbic supplements on harmful effects induced hyperuricemia albino Wistar rats.Forty rats were subgrouped into...
Abstract Malathion (MA) is a widely used pesticide in agriculture. It can cause toxicity different organs of the body. Rosmarinic acid (RO) found rosemary extract that be absorbed through gastrointestinal tract mucosa with potent antioxidant, and anti‐inflammatory potential. The current study designed to investigate potential RO protect lung after MA administration. Forty albino rats were allocated equally four groups. C‐group received corn oil. RO‐group orally. MA‐group MA. MA‐RO‐group...
The period of peri-menopause (PMP) is characterized by hormonal fluctuations that impact the strength and health bones. Oxytocin (OX), a small peptide known to be present in bone tissue, focus this study. objective research gain better understanding how OX precisely functions remodeling process mandibular bone. This seen as crucial step preventing loss both cortical trabecular during PMP. current findings indicate plays role preserving compact tissues, enhancing mineral-to-matrix ratio,...
<p><strong>Background:</strong> Cyclophosphamide disturbs the oxidant and antioxidant balance that is associated with several unwanted toxic effects induction of secondary cancers. The aim this study was to test protective Sulforaphane on cyclophosphamide toxicity rat urinary bladder.</p><p><strong>Methods:</strong> 32 male albino rats were divided into 4 groups, 8 animal each (n=8). Group I received saline intra-peritoneal, group II 5 mg/kg...
Abstract Aspartame is a synthetic sweetener that unlikely to have negative impact on the cerebellar cortex. The current study was designed evaluate histopathological changes in cortex of aspartame-treated albino rats and possibility recovery from aspartame induced injury. Three groups six mature male rats, totaling 18, were allocated. Daily doses distilled water given control group. Group 2 (ASP group): received 250 mg/kg ASP by oral rote for 12 weeks. Group3 (Recovery) mg/kg/day eight...
Abstract It was reported that hesperidin (HSD) is an ingredient extracted from lemon and orange could play a role in the protection against neurodegenerative diseases. The link between diabetic condition cognitive ability still not fully understood. current research work designed conducted to help understanding HSD functions rat model of diabetes. Forty rats were assigned into four groups, two them developed Rats received which appeared protect reduce pro-inflammatory mediators. In...