A5076793468- Circular RNAs in diseases
- Plant-Microbe Interactions and Immunity
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Nematode management and characterization studies
- Extracellular vesicles in disease
- Legume Nitrogen Fixing Symbiosis
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Plant Stress Responses and Tolerance
- Plant Pathogenic Bacteria Studies
- Macrophage Migration Inhibitory Factor
- Systemic Sclerosis and Related Diseases
- Plant tissue culture and regeneration
- Plant Parasitism and Resistance
- Plant Pathogens and Fungal Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Proteomics Techniques and Applications
- Lymphatic System and Diseases
- Plant Micronutrient Interactions and Effects
- Galectins and Cancer Biology
- Plant responses to water stress
- Fungal and yeast genetics research
- GDF15 and Related Biomarkers
- Identification and Quantification in Food
Huaiyin Normal University
2013-2024
Xi'an Medical University
2024
Guangdong Academy of Medical Sciences
2021-2024
Guangdong Provincial People's Hospital
2021-2024
Air Force Medical University
2023-2024
Xijing Hospital
2023-2024
Sun Yat-sen Memorial Hospital
2015-2023
Sun Yat-sen University
2015-2023
Southern Medical University
2023
State Key Laboratory of Oncology in South China
2020-2023
Patients with bladder cancer (BCa) clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN BCa. However, approximately 20% of BCa exhibits low expression, suggesting a VEGF-C–independent mechanism for Herein, we demonstrate that cell–secreted exosome-mediated lymphangiogenesis promoted manner. We identified exosomal long noncoding RNA (lncRNA), termed metastasis-associated transcript 2 (LNMAT2), stimulated human lymphatic...
Abstract Background Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma (PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs, been proposed to mediate the progression diverse types tumors. However, role and underlying regulatory mechanisms circRNAs in LN metastasis PDAC remain unknown. Methods Next-generation sequencing was used identify differentially expressed between normal adjacent tissues. In vitro...
Small ubiquitin-like modifier (SUMO) binding (termed SUMOylation) emerged as the inducer for sorting of bioactive molecules into extracellular vesicles (EVs), triggering lymphangiogenesis and further driving tumor lymph node (LN) metastasis, but precise mechanisms remain largely unclear. Here, we show that bladder cancer (BCa) cell-secreted EVs mediated intercellular communication with human lymphatic endothelial cells (HLECs) through transmission long noncoding RNA ELNAT1 promoted LN...
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced cancers; however, the functional annotation and mechanism of CAFs early-stage cancers remain elusive. Utilizing single-cell RNA sequencing spatial transcriptomic, we identify a previously unknown PDGFRα+ITGA11+ CAF subset bladder cancer (BCa). Multicenter clinical analysis 910-case cohort confirms that are associated with lymphovascular invasion (LVI) poor prognosis BCa. These facilitate LVI lymph node (LN)...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Long non‐coding RNAs (lncRNAs) are important regulators in pathological processes, yet their potential roles PDAC poorly understood. Here, we identify fundamental role for novel lincRNA, linc00511, the progression of PDAC. Linc00511 levels tissue specimens and cell lines were examined by quantitative real‐time PCR. Corresponding adjacent non‐neoplastic tissues used as controls. The function linc00511 was determined RNA...
Accumulating evidence suggests that circular RNAs (circRNAs) are important participants in cancer progression. However, the biological processes and underlying mechanisms of circRNAs pancreatic ductal adenocarcinoma (PDAC) unclear.CircRNAs were verified by Sanger sequencing. Colony formation, 5-Ethynyl-2'-deoxyuridine (EdU), Transwell assays performed to investigate effect circBFAR on proliferation, invasion, migration PDAC cells vitro. RNA pull-down conducted verify binding with microRNA...
Abstract Background The activation of NF-κB signaling pathway is regarded as the dominant process that correlates with tumorigenesis. Recently, increasing evidence shows long noncoding RNAs (lncRNAs) play crucial roles in sustaining pathway. However, underlying mechanisms have not yet been elucidated. Methods expression and clinical features PLACT1 were analyzed a 166-case cohort PDAC by qRT-PCR situ hybridization. functional role was evaluated both vitro vivo experiments. Chromatin...
Lymphatic metastasis constitutes a leading cause of recurrence and mortality in bladder cancer. Accumulating evidence indicates that lymphangiogenesis is indispensable to trigger lymphatic metastasis. However, the specific mechanism poorly understood. In present study, we revealed pathway involved cancer, which circular RNA (circRNA) facilitated vascular endothelial growth factor C (VEGF-C)-independent manner. Novel circRNA circEHBP1 was markedly upregulated cancer correlated positively with...
Circular RNAs (circRNA) containing retained introns are normally sequestered in the nucleus. Dysregulation of cellular homeostasis can drive their nuclear export, which may be involved cancer metastasis. However, mechanism underlying circRNA export and its role lymph node (LN) metastasis bladder remain unclear. Here, we identify an intron-retained circRNA, circNCOR1, that is significantly downregulated LN metastatic negatively associated with poor prognosis patients. Overexpression circNCOR1...
Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination. However, the regulatory mechanism underlying mutation-driven LN remains unclear. Herein, we found with (KRASG12D PDAC) sustained extracellular vesicle-mediated (EV-mediated) transmission of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) a...
Circular RNAs (circRNA) contribute to cancer stemness, proliferation, and metastasis. The biogenesis of circRNAs can be impacted by the genetic landscape tumors. Herein, we identified a novel circRNA, circARFGEF2 (hsa_circ_0060665), which was upregulated in KRASG12D pancreatic ductal adenocarcinoma (PDAC) positively associated with PDAC lymph node (LN) CircARFGEF2 overexpression significantly facilitated LN metastasis vitro vivo. Mechanistically, activated alternative splicing factor QKI-5,...
Our data suggest that B. cereus AR156 can promote the enrichment of beneficial microorganisms in plant rhizosphere by regulating salicylic acid (SA) and jasmonic (JA)/ethylene (ET) signaling pathways plants, thereby playing a role controlling bacterial wilt disease. Meanwhile, Spearman correlation analysis showed relative abundances these bacteria were correlated with secretion root exudates.
Circular RNAs (circRNAs) circularized by back-splicing of pre-mRNA are widely expressed and affected the proliferation, invasion metastasis bladder cancer (BCa). However, mechanism underlying circRNA biogenesis in mediating distant BCa still unexplored.RNA sequencing data between normal adjacent tissues was applied to identify differentially circRNAs. The functions circNIPBL were investigated via a series biochemical experiments. Clinical significance examined cohort larger tissues.In...
Abstract Lymph node (LN) metastasis is one of the predominant metastatic routes non-small cell lung cancer (NSCLC) and considered as a leading cause for unsatisfactory prognosis patients. Although lymphangiogenesis well-recognized crucial process in mediating LN metastasis, regulatory mechanism involving NSCLC remains unclear. In this study, we employed high-throughput sequencing to identify novel circular RNA (circRNA), circTLCD4-RWDD3, which was significantly upregulated extracellular...
Acidic soils inhibit crop yield and reduce grain quality. One of the major contributing factors to acidic soil is presence soluble aluminum (Al3+) ions, but mechanisms underlying plant responses Al3+ toxicity remain elusive. Nitric oxide (NO) an important messenger participates in various physiological responses. Here, we demonstrate that induced increase NO rice seedlings; adding exogenous alleviated related growth photosynthetic capacity, effects could be reversed by suppressing...
The heavy metal cadmium is a common environmental contaminant in soils and has adverse effects on crop growth development. signaling processes plants that initiate cellular responses to stress have been shown be located the plasma membrane (PM). A better understanding of PM proteome response might provide new insights for improving stress-tolerant crops. Nitric oxide (NO) reported involved plant (Cd) stress. To further investigate how NO modulates protein changes during Cd stress,...
The long intergenic non-coding RNA, regulator of reprogramming (linc-ROR) is an oncogene and plays a key role in the embryonic stem cell maintenance involved cancer progression. objective this study was to analyze linc-ROR expression pancreatic ductal adenocarcinoma (PDAC) determine regulation effects on proliferation invasion cells, as well properties stem-like cells (CSLCs). In study, we found that up-regulated PDAC tissues related poor prognosis. Linc-ROR knockdown inhibited growth...
Abstract Background Cancer-associated fibroblasts (CAFs) play pivotal roles in chemoresistance of pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanisms are poorly understood. Revealing cross-talk network between tumor stroma and cancer developing effective strategies against oxaliplatin resistance highly desired clinic. Methods High-throughput sequence was used to screened key circRNAs transmitted by extracellular vesicles (EVs) from CAFs cells. The associations...
Patients with advanced prostate cancer (PCa) have poor prognosis. Circular RNAs (circRNAs) regulate biological processes in a variety of cancers, but the precise roles circRNAs PCa are poorly understood. Herein, we identified novel circRNA, termed circMBOAT2 (has_circ_0007334), which was significantly overexpressed tissues and cell lines. Overexpression associated high Gleason score, pathological T stage, promoted proliferation, migration, invasion cells vitro, enhanced tumorigenesis...
Abstract Application of plant growth‐promoting rhizobacteria (PGPR) has been considered as an environmentally friendly method for crop yield promotion well disease management. Efforts have devoted to unraveling mechanisms involved in bacteria–plant and bacteria–pathogen interactions. However, little is known on the effect interaction among PGPR, soil, plant. We compared growth capacity biofertilizer Ning Shield, a consortium bacterial preparation used (BF), its mixture with compost...
Abstract Background Cancer‐associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor‐derived extracellular vesicles (EVs) are the critical mediators involved crosstalk between cells and stromal cells, contributing to metastasis of cancers. Yet, biological mechanisms tumor‐derived EVs triggering CAFs phenotype stimulate lymph node (LN) bladder (BCa) largely unknown. Here, we aimed explore effects molecular...
Watermelon Fusarium wilt caused by oxysporum f. sp. niveum (FON) is one of the most devastating diseases in watermelon production. Biological control approaches are efficient and environmentally-friendly, thus have aroused broad interest. However, only a few biocontrol factors/molecules been characterized due to varied genomes diversified secreted secondary metabolites microorganisms. We report screen identification Bacillus amyloliquefaciens strain HSSN09 with high antagonism FON growth...